Zobrazeno 1 - 10
of 960
pro vyhledávání: '"R, Gilson"'
Autor:
Madeline G. Dans, Coralie Boulet, Gabrielle M. Watson, William Nguyen, Jerzy M. Dziekan, Cindy Evelyn, Kitsanapong Reaksudsan, Somya Mehra, Zahra Razook, Niall D. Geoghegan, Michael J. Mlodzianoski, Christopher Dean Goodman, Dawson B. Ling, Thorey K. Jonsdottir, Joshua Tong, Mufuliat Toyin Famodimu, Mojca Kristan, Harry Pollard, Lindsay B. Stewart, Luke Brandner-Garrod, Colin J. Sutherland, Michael J. Delves, Geoffrey I. McFadden, Alyssa E. Barry, Brendan S. Crabb, Tania F. de Koning-Ward, Kelly L. Rogers, Alan F. Cowman, Wai-Hong Tham, Brad E. Sleebs, Paul R. Gilson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract With resistance to most antimalarials increasing, it is imperative that new drugs are developed. We previously identified an aryl acetamide compound, MMV006833 (M-833), that inhibited the ring-stage development of newly invaded merozoites. H
Externí odkaz:
https://doaj.org/article/ff89181888414cdebed058704ff392b1
Autor:
Madeline G. Dans, Coralie Boulet, Gabrielle M. Watson, William Nguyen, Jerzy M. Dziekan, Cindy Evelyn, Kitsanapong Reaksudsan, Somya Mehra, Zahra Razook, Niall D. Geoghegan, Michael J. Mlodzianoski, Christopher Dean Goodman, Dawson B. Ling, Thorey K. Jonsdottir, Joshua Tong, Mufuliat Toyin Famodimu, Mojca Kristan, Harry Pollard, Lindsay B. Stewart, Luke Brandner-Garrod, Colin J. Sutherland, Michael J. Delves, Geoffrey I. McFadden, Alyssa E. Barry, Brendan S. Crabb, Tania F. de Koning-Ward, Kelly L. Rogers, Alan F. Cowman, Wai-Hong Tham, Brad E. Sleebs, Paul R. Gilson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/36bf3afec36e4aac961dcc7fb75d1e5e
Autor:
Ethan L. Pitman, Natalie A. Counihan, Joyanta K. Modak, Mrittika Chowdury, Paul R. Gilson, Chaille T. Webb, Tania F. de Koning-Ward
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2024)
Apicomplexan parasites that reside within a parasitophorous vacuole harbor a conserved pore-forming protein that enables small-molecule transfer across the parasitophorous vacuole membrane (PVM). In Plasmodium parasites that cause malaria, this nutri
Externí odkaz:
https://doaj.org/article/2c2296a400ba4f69a1d25067b58f9743
Autor:
Greta E Weiss, Robert J Ragotte, Doris Quinkert, Amelia M Lias, Madeline G Dans, Coralie Boulet, Oliver Looker, Olivia D Ventura, Barnabas G Williams, Brendan S Crabb, Simon J Draper, Paul R Gilson
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011182 (2023)
The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is the current leading blood-stage malaria vaccine candidate. PfRH5 functions as part of the pentameric PCRCR complex containing PTRAMP, CSS, PfCyRPA and PfRIPR, all of which ar
Externí odkaz:
https://doaj.org/article/860d3157d96a47f895c9adb7940cc078
Autor:
Molly Parkyn Schneider, Oliver Looker, Maria Rebelo, David S. Khoury, Matthew W. A. Dixon, Claude Oeuvray, Brendan S. Crabb, James McCarthy, Paul R. Gilson
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
M5717 is a promising antimalarial drug under development that acts against multiple stages of the life cycle of Plasmodium parasites by inhibiting the translation elongation factor 2 (PfeEF2), thereby preventing protein synthesis. The parasite cleara
Externí odkaz:
https://doaj.org/article/c2406534d5854e6ab1c7c2aaa0f7936b
Autor:
Jason V. Tso, Casey G. Turner, Chang Liu, Ganesh Prabakaran, Mekensie Jackson, Angelo Galante, Carla R. Gilson, Craig Clark, B. Robinson Williams, Arshed A. Quyyumi, Aaron L. Baggish, Jonathan H. Kim
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 12 (2023)
Background Clinically relevant aortic dilatation (>40 mm) and increased cardiovascular risk are common among retired professional American‐style football athletes. Among younger athletes, the effect of American‐style football participation on aor
Externí odkaz:
https://doaj.org/article/0b6a56b741664a3e9cb3e737ea67a1be
Autor:
Madeline G Dans, Henni Piirainen, William Nguyen, Sachin Khurana, Somya Mehra, Zahra Razook, Niall D Geoghegan, Aurelie T Dawson, Sujaan Das, Molly Parkyn Schneider, Thorey K Jonsdottir, Mikha Gabriela, Maria R Gancheva, Christopher J Tonkin, Vanessa Mollard, Christopher Dean Goodman, Geoffrey I McFadden, Danny W Wilson, Kelly L Rogers, Alyssa E Barry, Brendan S Crabb, Tania F de Koning-Ward, Brad E Sleebs, Inari Kursula, Paul R Gilson
Publikováno v:
PLoS Biology, Vol 21, Iss 4, p e3002066 (2023)
With emerging resistance to frontline treatments, it is vital that new antimalarial drugs are identified to target Plasmodium falciparum. We have recently described a compound, MMV020291, as a specific inhibitor of red blood cell (RBC) invasion, and
Externí odkaz:
https://doaj.org/article/d4ae40a3c3394669ac6efd4a149b5ec0
Autor:
Claudia B. G. Barnes, Madeline G. Dans, Thorey K. Jonsdottir, Brendan S. Crabb, Paul R. Gilson
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
The cation efflux pump Plasmodium falciparum ATPase 4 (PfATP4) maintains Na+ homeostasis in malaria parasites and has been implicated in the mechanism of action of many structurally diverse antimalarial agents, including >7% of the antimalarial compo
Externí odkaz:
https://doaj.org/article/08cdd3cfaeed4e469e4110a4b51aef51
Autor:
Jason V. Tso, Casey G. Turner, Chang Liu, Syed Ahmad, Abbas Ali, Steve Selvaraj, Angelo Galante, Carla R. Gilson, Craig Clark, B. Robinson Williams, Arshed A. Quyyumi, Aaron L. Baggish, Jonathan H. Kim
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 6 (2022)
Background Ventricular–arterial (VA) coupling is defined as the ratio between arterial elastance (EA) and left ventricular elastance (ELV). VA uncoupling, as occurs in hypertensive heart disease, is associated with adverse outcomes. This study soug
Externí odkaz:
https://doaj.org/article/aef10b868714441daa68d9c0bf4e49ea
Autor:
Mikha Gabriela, Kathryn M Matthews, Cas Boshoven, Betty Kouskousis, Thorey K Jonsdottir, Hayley E Bullen, Joyanta Modak, David L Steer, Brad E Sleebs, Brendan S Crabb, Tania F de Koning-Ward, Paul R Gilson
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1009977 (2022)
Plasmodium falciparum exports ~10% of its proteome into its host erythrocyte to modify the host cell's physiology. The Plasmodium export element (PEXEL) motif contained within the N-terminus of most exported proteins directs the trafficking of those
Externí odkaz:
https://doaj.org/article/255e629500da4e7bab4f1622c9b59485