Zobrazeno 1 - 10
of 4 627
pro vyhledávání: '"R, Gilbert"'
Autor:
Henriette U. Balinda, William J. Kelly, Virginia G. Kaklamani, Kate I. Lathrop, Marcela Mazo Canola, Pegah Ghamasaee, Gangadhara R. Sareddy, Joel Michalek, Andrea R. Gilbert, Prathibha Surapaneni, Stefano Tiziani, Renu Pandey, Jennifer Chiou, Alessia Lodi, John R. Floyd, Andrew J. Brenner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Sacituzumab Govitecan (SG) is an antibody-drug conjugate that has demonstrated efficacy in patients with TROP-2 expressing epithelial cancers. In a xenograft model of intracranial breast cancer, SG inhibited tumor growth and increased mouse
Externí odkaz:
https://doaj.org/article/6d91bfe0b91b4bbd854a96e2dea7ba0a
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-11 (2024)
Abstract Despite being mutated in 92% of TP53 mutant cancers, how mutations on p53 isoforms affect their activities remain largely unknown. Therefore, exploring the effect of mutations on p53 isoforms activities is a critical, albeit unexplored area
Externí odkaz:
https://doaj.org/article/5366a9b27ccf491d81dd6ccae5616d55
Autor:
Jinkyu Jung, Eric L. Schneider, Wei Zhang, Hua Song, Meili Zhang, William Chou, Niranjan Meher, Henry F. VanBrocklin, Mary Helen Barcellos-Hoff, Tomoko Ozawa, Mark R. Gilbert, Daniel V. Santi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Central nervous system tumors have resisted effective chemotherapy because most therapeutics do not penetrate the blood-tumor-brain-barrier. Nanomedicines between ~ 10 and 100 nm accumulate in many solid tumors by the enhanced permeability a
Externí odkaz:
https://doaj.org/article/3d5e6d583d9c4105b0310e06048dd4f3
Autor:
Kevin G. Buell, MBBS, MS, Kyle A. Carey, MPH, Nicole Dussault, MD, William F. Parker, MD, PhD, Jay Dumanian, MD, Sivasubramanium V. Bhavani, MD, MS, Emily R. Gilbert, MD, Christopher J. Winslow, MD, Nirav S. Shah, MD, MPH, Majid Afshar, MD, MSCR, Dana P. Edelson, MD, MS, Matthew M. Churpek, MD, MPH, PhD
Publikováno v:
Critical Care Explorations, Vol 6, Iss 10, p e1165 (2024)
BACKGROUND:. Early diagnostic uncertainty for infection causes delays in antibiotic administration in infected patients and unnecessary antibiotic administration in noninfected patients. OBJECTIVE:. To develop a machine learning model for the early d
Externí odkaz:
https://doaj.org/article/9d8b140b5f83474eb2affa00d3efb991
Autor:
Matthew M. Churpek, MD, MPH, PhD, ATSF, Ryan Ingebritsen, Kyle A. Carey, MPH, Saieesh A. Rao, MD, Emily Murnin, MD, Tonela Qyli, MD, Madeline K. Oguss, MS, Jamila Picart, MD, Leena Penumalee, BS, Benjamin D. Follman, MD, Lily K. Nezirova, MD, Sean T. Tully, DO, Charis Benjamin, MPH, Christopher Nye, MD, Emily R. Gilbert, MD, Nirav S. Shah, MD, MPH, Christopher J. Winslow, MD, Majid Afshar, MD, MSCR, Dana P. Edelson, MD, MS
Publikováno v:
Critical Care Explorations, Vol 6, Iss 10, p e1161 (2024)
IMPORTANCE:. Timely intervention for clinically deteriorating ward patients requires that care teams accurately diagnose and treat their underlying medical conditions. However, the most common diagnoses leading to deterioration and the relevant thera
Externí odkaz:
https://doaj.org/article/921b24df79504e04a6b324ffb3125253
Autor:
Alvina Acquaye‐Mallory, Elizabeth Vera, Anna Choi, Kathleen Wall, Mark R. Gilbert, Terri S. Armstrong
Publikováno v:
Cancer Medicine, Vol 13, Iss 15, Pp n/a-n/a (2024)
Abstract Objective High self‐efficacy is associated with improved self‐care and reduced symptoms in cancer patients but has not been fully interrogated in adults with central nervous system (CNS) cancers. We aimed to identify the relationship bet
Externí odkaz:
https://doaj.org/article/fa6a3dfd80ab4e949d2ebb9976ae5704
Autor:
Herui Wang, Rogelio Medina, Juan Ye, Yaping Zhang, Samik Chakraborty, Alex Valenzuela, Ondrej Uher, Katerina Hadrava Vanova, Mitchell Sun, Xueyu Sang, Deric M. Park, Jan Zenka, Mark R. Gilbert, Karel Pacak, Zhengping Zhuang
Publikováno v:
Advanced Science, Vol 11, Iss 14, Pp n/a-n/a (2024)
Abstract Despite strides in immunotherapy, glioblastoma multiforme (GBM) remains challenging due to low inherent immunogenicity and suppressive tumor microenvironment. Converting “cold” GBMs to “hot” is crucial for immune activation and impro
Externí odkaz:
https://doaj.org/article/402be77c1897447c8a899980d3ead908
Publikováno v:
Cancer Medicine, Vol 12, Iss 16, Pp 16945-16957 (2023)
Abstract Background Clinical outcome assessments (COAs) are key to patient‐centered evaluation of novel interventions and supportive care. COAs are particularly informative in oncology where a focus on how patients feel and function is paramount, b
Externí odkaz:
https://doaj.org/article/9e0ec76aee234b0d95ff84b7dfa6b80b
Autor:
Huan Liang, Kyle A. Carey, Priti Jani, Emily R. Gilbert, Majid Afshar, L. Nelson Sanchez-Pinto, Matthew M. Churpek, Anoop Mayampurath
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
IntroductionCritical deterioration in hospitalized children, defined as ward to pediatric intensive care unit (PICU) transfer followed by mechanical ventilation (MV) or vasoactive infusion (VI) within 12 h, has been used as a primary metric to evalua
Externí odkaz:
https://doaj.org/article/4efc93421c3e4a89bbd7f23694db2037
Autor:
Amanda L. King, Alvina A. Acquaye-Mallory, Elizabeth Vera, Tito Mendoza, Jennifer Reyes, Macy L. Stockdill, Mark R. Gilbert, Terri S. Armstrong
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-10 (2023)
Abstract Background Primary brain tumor (PBT) patients experience higher levels of distress and anxiety than other solid tumor patients, particularly at the time of clinical evaluation when uncertainty about disease status is high (“scanxiety”).
Externí odkaz:
https://doaj.org/article/bbf381db329b4115b5ea6783adc0a7cb