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Explicit solutions for a class of indirect pharmacodynamic response models

Autor: P. Jordan, R. Gieschke

Publikováno v: Computer Methods and Programs in Biomedicine. 77:91-97

Explicit solutions for four, ordinary differential equation (ODE)-based, types of indirect response models are presented. These response models were introduced by Dayneka et al. in 1993 [J. Pharmacokinet. Biopharm. 21 (1993) 457] to describe pharmaco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd47e808b73e2f59898f56f23e20dff
https://doi.org/10.1016/j.cmpb.2004.02.002

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Akademický článek

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Akademický článek

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Population pharmacokinetic analysis of the major metabolites of capecitabine

Autor: R, Gieschke, B, Reigner, K S, Blesch, J L, Steimer

Publikováno v: Journal of pharmacokinetics and pharmacodynamics. 29(1)

Capecitabine has been developed as an orally administered tumor selective fluoropyrimidine for use in the treatment of breast and colorectal cancer. The metabolic pathway for capecitabine includes 5'-deoxy-5-fluorocytidine (5'-DFCR) and 5'-deoxy-5-fl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6223b4d1a3ab44c8c035b28bb2a20fb4
https://pubmed.ncbi.nlm.nih.gov/12194534

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Pharmacometrics: modelling and simulation tools to improve decision making in clinical drug development

Autor: J L Steimer, R Gieschke

Publikováno v: European journal of drug metabolism and pharmacokinetics. 25(1)

There is broad recognition within the pharmaceutical industry that the drug development process, especially the clinical part of it, needs considerable improvement to cope with rapid changes in research and health care environments. Modelling and sim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::866d2e34096774562d448fa1e748c7f5
https://pubmed.ncbi.nlm.nih.gov/11032091

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Interaction studies with moclobemide

Autor: S. Basic, R. Zimmer, R. Gieschke, R. Fischbach

Publikováno v: Acta Psychiatrica Scandinavica. 82:84-86

Drug interactions with moclobemide given to healthy subjects and depressed patients are reviewed. The drugs investigated for safety were antihypertensives, digoxin, oral contraceptives, anticoagulants and benzodiazepines. Cimetidine was studied for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae3a092746413b57058e2896e4b05de3
https://doi.org/10.1111/j.1600-0447.1990.tb05343.x

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Effects of bretazenil vs. zolpidem and placebo on experimentally induced sleep disturbance in healthy volunteers

Autor: R, Gieschke, R, Cluydts, J, Dingemanse, J, De Roeck, W, De Cock

Publikováno v: Methods and findings in experimental and clinical pharmacology. 16(9)

The effects of bretazenil 0.25 and 0.5 mg, a partial agonist at the benzodiazepine receptor, on sleep electroencephalogram (EEG), subjective sleep quality and morning psychomotor performance were compared to zolpidem 10 mg and placebo using noise as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::26c19de5f98e046d95616a4827929f4d
https://pubmed.ncbi.nlm.nih.gov/7746029

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