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Akademický článek

Enterovirus-infected β-cells induce distinct response patterns in BDCA1+ and BDCA3+ human dendritic cells.

Autor: Barbara M Schulte, Paul R Gielen, Esther D Kers-Rebel, Gerty Schreibelt, Frank J M van Kuppeveld, Gosse J Adema

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0121670 (2015)

Enteroviruses often cause mild disease, yet are also linked to development of autoimmune diabetes. Dendritic cells (DCs) shape both innate and adaptive immune responses, including anti-viral responses. How different human DC subsets shape anti-viral

Externí odkaz: https://doaj.org/article/35a2a9f8783047cfac97ad5199af7ea2

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Expression profiling of immune inhibitory Siglecs and their ligands in patients with glioma

Autor: Gosse J. Adema, Pieter Wesseling, Sandra A. J. F. H. Bossman, Barbara M. Schulte, Paul R. Gielen, Mark ter Laan, Kim C. M. Santegoets, Christian Büll, Esther D. Kers-Rebel, Benno Küsters

Publikováno v: Cancer Immunology, Immunotherapy, 68(6), 937-949. Springer Science and Business Media Deutschland GmbH
Cancer Immunology, Immunotherapy
Cancer Immunology Immunotherapy, 68, 6, pp. 937-949
Santegoets, K C M, Gielen, P R, Büll, C, Schulte, B M, Kers-Rebel, E D, Küsters, B, Bossman, S A J F H, ter Laan, M, Wesseling, P & Adema, G J 2019, ' Expression profiling of immune inhibitory Siglecs and their ligands in patients with glioma ', Cancer Immunology, Immunotherapy, vol. 68, no. 6, pp. 937-949 . https://doi.org/10.1007/s00262-019-02332-w
Cancer Immunology Immunotherapy, 68, 937-949

Gliomas appear to be highly immunosuppressive tumors, with a strong myeloid component. This includes MDSCs, which are a heterogeneous, immature myeloid cell population expressing myeloid markers Siglec-3 (CD33) and CD11b and lacking markers of mature

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27c393a6f6b23a059ab646134acd110
https://hdl.handle.net/2066/203999

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T-Cell Lymphopenia in Patients with Advanced Thyroid Carcinoma Is Associated with Poor Prognosis

Autor: Paul R. Gielen, Jan W. A. Smit, Gosse J. Adema, Katrin Rabold, Romana T. Netea-Maier, Esther D. Kers-Rebel, Mihai G. Netea

Publikováno v: Oncologist, 24, 3, pp. E106-E110
Oncologist, 24, E106-E110

Background Aggressive forms of thyroid carcinoma (TC) show an abundant infiltration of immune cells, and this correlates with prognosis. However, little is known about circulating immune cell levels in advanced TC. Objective Investigate T-cell and my

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08988b1839e26f6015b36d3f5c5e5ee9
https://hdl.handle.net/2066/202146

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Akademický článek

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Enterovirus Exposure Uniquely Discriminates Type 1 Diabetes Patients with a Homozygous from a Heterozygous Melanoma Differentiation-Associated Protein 5/Interferon Induced with Helicase C Domain 1 A946T Genotype

Autor: Katharina Lind, Barbara M. Schulte, Paul R. Gielen, Esther D. Kers-Rebel, Gosse J. Adema, Cees J. Tack, Lammy D. Elving, Amy Prosser, Malin Flodström-Tullberg

Publikováno v: Viral Immunology, 29, 7, pp. 389-97
Viral Immunology, 29, 389-97

Contains fulltext : 172472.pdf (Publisher’s version ) (Closed access) In children at risk for type 1 diabetes, innate immune activity is detected before seroconversion. Enterovirus infections have been linked to diabetes development, and a polymorp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::863d582c8b414e6fd4b60a631bdeddf5
https://pubmed.ncbi.nlm.nih.gov/27482829

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Elevated levels of polymorphonuclear myeloid-derived suppressor cells in patients with glioblastoma highly express S100A8/9 and arginase and suppress T cell function

Autor: Gosse J. Adema, Mark ter Laan, Pieter Wesseling, Sandra A. J. F. H. Bossman, Barbara M Schulte, Kiek Verrijp, Esther D. Kers-Rebel, Paul R Gielen

Publikováno v: Gielen, P R, Schulte, B M, Kers-Rebel, E D, Verrijp, K, Bossman, S A J F H, Ter Laan, M, Wesseling, P & Adema, G J 2016, ' Elevated levels of polymorphonuclear myeloid-derived suppressor cells in patients with glioblastoma highly express S100A8/9 and arginase and suppress T cell function ', Neuro-Oncology, vol. 18, no. 9, pp. 1253-64 . https://doi.org/10.1093/neuonc/now034
Neuro-Oncology, 18(9), 1253-64. Oxford University Press
Neuro-Oncology, 18, 9, pp. 1253-64
Neuro-Oncology, 18, 1253-64
Neuro-Oncology, 18(9), 1253. Oxford University Press

Contains fulltext : 167769.pdf (Publisher’s version ) (Closed access) BACKGROUND: Gliomas are primary brain tumors that are associated with a poor prognosis. The introduction of new treatment modalities (including immunotherapy) for these neoplasms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60090862d2b78c831cd7640746469450
https://doi.org/10.1093/neuonc/now034

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Anti-GD2 mAb and Vorinostat synergize in the treatment of neuroblastoma

Autor: Paul R. Gielen, Melissa Wassink, Martijn H. den Brok, Peter M. Hoogerbrugge, Michiel Kroesen, Gosse J. Adema, Louis Boon, Inna Armandari, Christian Büll, Maaike W. G. Looman, Ingrid C. Brok

Publikováno v: Oncoimmunology, 5, 6, pp. e1164919
Oncoimmunology
Oncoimmunology, 5, e1164919

Contains fulltext : 171471.pdf (Publisher’s version ) (Open Access) Neuroblastoma (NBL) is a childhood malignancy of the sympathetic nervous system. For high-risk NBL patients, the mortality rate is still over 50%, despite intensive multimodal trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e8e017b29146e05d025c33cefba38d3
https://hdl.handle.net/2066/171471

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S3-Leitlinie zur Diagnostik und Therapie bipolarer Störungen

Autor: Frank Padberg, H. Giesler, Harald Scherk, D. Geissler, Daniel Strech, Oliver Gruber, Peter Brieger, Tom Bschor, Peter Bräunig, R. Gielen, Peter Falkai, C. Muche-Borowski, Thomas C. Baghai, Michael Bauer, Thomas D. Meyer, Andrea Pfennig, K. H. Möhrmann, Ina Kopp

Publikováno v: Der Nervenarzt. 83:568-586

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03909165a497ef314d80fdde93f6d2a5
https://doi.org/10.1007/s00115-011-3415-3

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Leitlinie Bipolare Störungen und die Bedeutung des Trialogs

Autor: T. Bock, R. Gielen, H. Giesler, D. Geissler

Publikováno v: Der Nervenarzt. 83:587-594

„Trialog“ meint die moglichst gleichberechtigte Zusammenarbeit von Betroffenen/Patienten und Behandlern sowie das selbstverstandliche Einbeziehen der Angehorigen. Das gilt fur die Therapie, die Antistigmaarbeit, bei der Planung der Versorgung, in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16400fe38410f6b39c6c970361c5b9c2
https://doi.org/10.1007/s00115-011-3416-2

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