Zobrazeno 1 - 10
of 67
pro vyhledávání: '"R, Geertsen"'
Autor:
David R. Betts, R. Geertsen, Roland Böni, Rainer Blasczyk, Pedro Romero, Donata Rimoldi, Reinhard Dummer, Jörg Willers, Xin Hong, Elisabeth Laine
Publikováno v:
International Journal of Cancer. 99:82-87
Expression of human leucocyte antigen (HLA) Class I molecules is essential for the recognition of malignant melanoma (MM) cells by CD8+ T lymphocytes. A complete or partial loss of HLA Class I molecules is a potent strategy for MM cells to escape fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac717965f1d01cdb8689cc2c11fe20ed
https://doi.org/10.1002/ijc.10284
https://doi.org/10.1002/ijc.10284
Publikováno v:
Blood. 97:523-527
Cutaneous T-cell lymphomas (CTCL) comprise a heterogeneous group of lymphoproliferative disorders that are characterized by an accumulation of T-lymphocytes in the skin and occasionally in blood known as Sézary syndrome (SS). In most cases the domi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ed90768b73d0c0303261564be9230a
https://doi.org/10.1182/blood.v97.2.523
https://doi.org/10.1182/blood.v97.2.523
Publikováno v:
International Journal of Cancer. 83:135-140
In advanced stages of malignant melanoma (MM), metastases to the CNS are frequently observed. Few results are available on trophic factors and immunological features involved in the process of invasion and adhesion of circulating metastatic cells int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c47a3bc2ed7b320780155b4e36e4ac6
https://doi.org/10.1002/(sici)1097-0215(19990924)83:1<135::aid-ijc23>3.0.co
https://doi.org/10.1002/(sici)1097-0215(19990924)83:1<135::aid-ijc23>3.0.co
Autor:
Jovan Pavlovic, Elisabeth Laine, Silvio Hemmi, Günter Burg, R. Geertsen, F.-Y. Yue, Reinhard Dummer
Publikováno v:
European Journal of Immunology. 29:1762-1773
IL-12 enhances cytolytic activity and proliferation of NK and T cells, and induces cytokines such as IFN-gamma. No direct effects on non-hematopoietic cells have been shown. This study investigates the effects of IL-12 on melanoma cells in vitro. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19aae2b1579e39203f99a6bed74c7659
https://doi.org/10.1002/(sici)1521-4141(199906)29:06<1762::aid-immu1762>3.0.co
https://doi.org/10.1002/(sici)1521-4141(199906)29:06<1762::aid-immu1762>3.0.co
Publikováno v:
Human Gene Therapy. 9:2363-2373
Adenovirus (AdV)-mediated gene expression of immune stimulators represents a valuable in vivo approach for gene therapy of human cancer. The expression level of the therapeutic gene is of crucial importance for the efficacy of this type of treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::098f9aab8fbb02e56e3c1bd0f59353f9
https://doi.org/10.1089/hum.1998.9.16-2363
https://doi.org/10.1089/hum.1998.9.16-2363
Autor:
R. Geertsen, Günther Franz L. Hofbauer, Günter Burg, Silvana Manolio, Reinhard Dummer, Feng-Yun Yue
Publikováno v:
Journal of Investigative Dermatology. 111:497-502
Expression of HLA class I molecules is essential for the recognition of tumor cells by CD8+ T cells. In this study, 48 bioptic samples of 42 patients in all stages of melanoma were investigated after short-time cultivation of tumor cells. To confirm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7adce53f8c091ced21dc77d57c71967b
https://doi.org/10.1046/j.1523-1747.1998.00305.x
https://doi.org/10.1046/j.1523-1747.1998.00305.x
Publikováno v:
Leukemia & Lymphoma. 28:515-522
Mycosis fungoides and the Sézary Syndrome are characterized by clonal accumulation of well differentiated T-helper memory cells in the skin and, in the case of the Sézary Syndrome, also in the blood and lymph nodes. Well known immunological abnorma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7dbdec348e3d43613063ea4e3a30480
https://doi.org/10.3109/10428199809058359
https://doi.org/10.3109/10428199809058359
Autor:
Günther F.L. Hofbauer, R. Geertsen, Silvana Manolio, F.-Y. Yue, Elisabeth Laine, Günter Burg, Reinhard Dummer
Publikováno v:
International Journal of Cancer. 71:630-637
IL-10 is a cytokine which shows various effects including inhibition of T-cell proliferation or HLA-dependent antigen presentation. In this study, we analysed the effects of exogenous or autocrine IL-10 on proliferation and expression of immunocritic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63fccefe9ea4125621a41c382ec3c999
https://doi.org/10.1002/(sici)1097-0215(19970516)71:4<630::aid-ijc20>3.0.co
https://doi.org/10.1002/(sici)1097-0215(19970516)71:4<630::aid-ijc20>3.0.co
Autor:
Jörg Willers, Thomas M. Kündig, Reinhard Dummer, R. Geertsen, Mirjana Urosevic, Elisabeth Laine, Günter Burg
Publikováno v:
The Journal of investigative dermatology. 117(6)
The presentation of endogenously synthesized peptides in association with HLA class I molecules allows the activation of CD8 + lymphocytes. Tumor cells often fail to present antigenic peptides resulting in the immune escape of metastasizing cells. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0cddeb9452e36c1873a04f09113f60
https://pubmed.ncbi.nlm.nih.gov/11886514
https://pubmed.ncbi.nlm.nih.gov/11886514
Publikováno v:
Melanoma research. 11(3)
Some immunotherapeutic approaches based on melanoma-associated antigens rely on in vitro cultivation of melanoma cells. A beneficial effect of interferons has been shown in melanoma. This study aimed to determine whether stimulation of patient-derive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ad01707acc8de9c215df428f881f996
https://pubmed.ncbi.nlm.nih.gov/11468509
https://pubmed.ncbi.nlm.nih.gov/11468509