Zobrazeno 1 - 10 of 126 pro vyhledávání: '"R, Falotico"'
1
Low-dose oral sirolimus reduces atherogenesis, vascular inflammation and modulates plaque composition in mice lacking the LDL receptor
Autor: Minghong Ma, D Praticò, T Cyrus, Tao Ding, Y Cheng, H Tian, R Falotico, L Zhao
Publikováno v: British Journal of Pharmacology. 156:774-785
Background and purpose: Chronic proliferative responses of different vascular cell types have been involved in the pathogenesis of atherosclerosis. However, their functional role remains to be established. Sirolimus reduces neointimal proliferation a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6c71f49fb93917fda6c1ca363332553
https://doi.org/10.1111/j.1476-5381.2008.00080.x
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2
Thiophene systems. 14. Synthesis and antihypertensive activity of novel 7-(cyclic amido)-6-hydroxythieno[3,2-b]pyrans and related compounds as new potassium channel activators
Autor: P J, Sanfilippo, J J, McNally, J B, Press, L J, Fitzpatrick, M J, Urbanski, L B, Katz, E, Giardino, R, Falotico, J, Salata, J B, Moore
Publikováno v: Journal of Medicinal Chemistry. 35:4425-4433
The synthesis and antihypertensive activity of novel 7-(cyclic amido)-6-hydroxy-5,5-dimethylthieno[3,2-b]pyrans and related compounds are described. The compounds were tested for oral antihypertensive activity in spontaneously hypertensive rats (SHR)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8debb2eee4ae6adb1a215a9327fe046c
https://doi.org/10.1021/jm00101a020
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3
Low-dose oral sirolimus reduces atherogenesis, vascular inflammation and modulates plaque composition in mice lacking the LDL receptor
Autor: L, Zhao, T, Ding, T, Cyrus, Y, Cheng, H, Tian, M, Ma, R, Falotico, D, Praticò
Publikováno v: British journal of pharmacology. 156(5)
Chronic proliferative responses of different vascular cell types have been involved in the pathogenesis of atherosclerosis. However, their functional role remains to be established. Sirolimus reduces neointimal proliferation after balloon angioplasty
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e264deafd04af42da0d877409d829e0c
https://pubmed.ncbi.nlm.nih.gov/19220291
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4
Cardiovascular actions of thrombin receptor activation in vivo
Autor: B P, Damiano, W M, Cheung, J A, Mitchell, R, Falotico
Publikováno v: The Journal of pharmacology and experimental therapeutics. 279(3)
Thrombin's cellular actions are mediated by a novel G-protein coupled transmembrane receptor. We infused SFLLRN, a peptide that directly activates thrombin receptors, into the left circumflex coronary artery (CFX) of anesthetized dogs to evaluate the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::81946781ff63bce7e85df7cbc1746b65
https://pubmed.ncbi.nlm.nih.gov/8968361
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5
Activation of vascular thrombin receptors mediates cardiac response to alpha-thrombin in isolated, perfused guinea pig heart
Autor: J. A. Mitchell, Bruce P. Damiano, W. M. Cheung, R. Falotico
Publikováno v: The American journal of physiology. 270(5 Pt 2)
alpha-Thrombin alters vascular tone via a cell surface receptor. We used isolated guinea pig hearts perfused with buffer at constant flow to assess the effects of thrombin-receptor activation on coronary perfusion pressure, left ventricular function,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c114a1d959f779b210bec8e4b72561a
https://pubmed.ncbi.nlm.nih.gov/8928863
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6
Cardiovascular profile of RWJ 29009, a new potassium channel activator, in anesthetized and conscious dogs
Autor: B P, Damiano, E C, Giardino, B J, Haertlein, G L, Stump, J A, Mitchell, R, Falotico
Publikováno v: Journal of cardiovascular pharmacology. 23(2)
RWJ-29009, (6S)-trans(-)-1-(6,7-dihydro-6-hydroxy-5,5-dimethyl-2-nitro-5 H-thieno[3,2-b]pyran-7-yl)-2-piperidinone, is a structurally novel and extremely potent potassium channel activator that may be useful for treatment of hypertension and ischemic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8d29535aa42e0174c9f4269af94f5f63
https://pubmed.ncbi.nlm.nih.gov/7511761
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7
RWJ 26629, a new potassium channel opener and vascular smooth muscle relaxant: a potential antihypertensive and antianginal agent
Autor: L B, Katz, E C, Giardino, J J, Salata, J B, Moore, R, Falotico
Publikováno v: The Journal of pharmacology and experimental therapeutics. 267(2)
The effects of trans-5,6-dihydro-6-hydroxy-5,5-dimethyl-2-nitro-7-(2-oxopiperidin -1-yl)-7H- thieno[3,2-b]pyran (RWJ 26629) were compared with those of the standard potassium channel opener cromakalim and several standard calcium channel blockers. RW
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2210fc5c509218e0118b9ce9f9d851e2
https://pubmed.ncbi.nlm.nih.gov/8246137
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8
Synthesis and SAR of 6-substituted purine derivatives as novel selective positive inotropes
Autor: J B, Press, R, Falotico, Z G, Hajos, R A, Sawyers, R M, Kanojia, L, Williams, B, Haertlein, J A, Kauffman, C, Lakas-Weiss, J J, Salata
Publikováno v: Journal of medicinal chemistry. 35(24)
A series of purine derivatives was prepared and examined for selective inotropic activity in vitro and in vivo. Thioether-linked derivatives were superior to their oxygen and nitrogen isosteres. Substitution of electron-withdrawing groups on the benz
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b5f881ba4cf5cd70d8d1ca74078ea1b0
https://pubmed.ncbi.nlm.nih.gov/1335073
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10
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