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Akademický článek

Low dose aspirin prevents endothelial dysfunction in the aorta and foetal loss in pregnant mice infected with influenza A virus

Autor: Madison Coward-Smith, Stella Liong, Osezua Oseghale, Jonathan R. Erlich, Mark A. Miles, Felicia Liong, Kurt Brassington, Steven Bozinovski, Ross Vlahos, Robert D. Brooks, Doug A. Brooks, John J. O’Leary, Stavros Selemidis

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Influenza A virus (IAV) infection in pregnancy resembles a preeclamptic phenotype characterised by vascular dysfunction and foetal growth retardation. Given that low dose aspirin (ASA) is safe in pregnancy and is used to prevent preeclampsia, we inve

Externí odkaz: https://doaj.org/article/3fc0146337bf43658a35e6dc48143063

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Akademický článek

TLR7 promotes chronic airway disease in RSV-infected mice

Autor: Mark A. Miles, Stella Liong, Felicia Liong, Madison Coward-Smith, Gemma S. Trollope, Osezua Oseghale, Jonathan R. Erlich, Robert D. Brooks, Jessica M. Logan, Shane Hickey, Hao Wang, Steven Bozinovski, John J. O’Leary, Doug A. Brooks, Stavros Selemidis

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Respiratory syncytial virus (RSV) commonly infects the upper respiratory tract (URT) of humans, manifesting with mild cold or flu-like symptoms. However, in infants and the elderly, severe disease of the lower respiratory tract (LRT) often occurs and

Externí odkaz: https://doaj.org/article/e057fb9f2c4a48098536263b49a04f2f

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Akademický článek

TLR9 Monotherapy in Immune-Competent Mice Suppresses Orthotopic Prostate Tumor Development

Autor: Mark A. Miles, Raymond Luong, Eunice E. To, Jonathan R. Erlich, Stella Liong, Felicia Liong, Jessica M. Logan, John O’Leary, Doug A. Brooks, Stavros Selemidis

Publikováno v: Cells, Vol 13, Iss 1, p 97 (2024)

Prostate cancer is ranked second in the world for cancer-related deaths in men, highlighting the lack of effective therapies for advanced-stage disease. Toll-like receptors (TLRs) and immunity have a direct role in prostate cancer pathogenesis, but T

Externí odkaz: https://doaj.org/article/61917abee6a14a65a0c6708159efdbcf

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Akademický článek

Influenza A virus elicits peri-vascular adipose tissue inflammation and vascular dysfunction of the aorta in pregnant mice.

Autor: Osezua Oseghale, Stella Liong, Madison Coward-Smith, Eunice E To, Jonathan R Erlich, Raymond Luong, Felicia Liong, Mark Miles, Shaghayegh Norouzi, Cara Martin, Sharon O'Toole, Robert D Brooks, Steven Bozinovski, Ross Vlahos, John J O'Leary, Doug A Brooks, Stavros Selemidis

Publikováno v: PLoS Pathogens, Vol 18, Iss 8, p e1010703 (2022)

Influenza A virus (IAV) infection during pregnancy initiates significant aortic endothelial and vascular smooth muscle dysfunction, with inflammation and T cell activation, but the details of the mechanism are yet to be clearly defined. Here we demon

Externí odkaz: https://doaj.org/article/87939b1b8d0043309e5d3dfd59bd4e58

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Akademický článek

Endothelial NOX4 Oxidase Negatively Regulates Inflammation and Improves Morbidity During Influenza A Virus Lung Infection in Mice

Autor: Keshia S. Hendricks, Eunice E. To, Raymond Luong, Felicia Liong, Jonathan R. Erlich, Ajay M. Shah, Stella Liong, John J. O’Leary, Doug A. Brooks, Ross Vlahos, Stavros Selemidis

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)

Endosomal NOX2 oxidase-dependent ROS production promotes influenza pathogenicity, but the role of NOX4 oxidase, which is highly expressed in the lung endothelium, is largely unknown. The aim of this study was to determine if endothelial NOX4 expressi

Externí odkaz: https://doaj.org/article/f21058aac2f04f4aa477f86461ab9ca7

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Akademický článek

Therapeutic Targeting of Endosome and Mitochondrial Reactive Oxygen Species Protects Mice From Influenza Virus Morbidity

Autor: Eunice E. To, Jonathan R. Erlich, Felicia Liong, Stella Liong, Raymond Luong, Osezua Oseghale, Mark A. Miles, Paris C. Papagianis, Kylie M. Quinn, Steven Bozinovski, Ross Vlahos, Robert D. Brooks, John J. O’Leary, Doug A. Brooks, Stavros Selemidis

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

There is an urgent need to develop effective therapeutic strategies including immunomodulators to combat influenza A virus (IAV) infection. Influenza A viruses increase ROS production, which suppress anti-viral responses and contribute to pathologica

Externí odkaz: https://doaj.org/article/a98e506ed5024879a44e694c00bb87b9

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Akademický článek

Glycolysis and the Pentose Phosphate Pathway Promote LPS-Induced NOX2 Oxidase- and IFN-β-Dependent Inflammation in Macrophages

Autor: Jonathan R. Erlich, Eunice E. To, Raymond Luong, Felicia Liong, Stella Liong, Osezua Oseghale, Mark A. Miles, Steven Bozinovski, Robert D. Brooks, Ross Vlahos, Stanley Chan, John J. O’Leary, Doug A. Brooks, Stavros Selemidis

Publikováno v: Antioxidants, Vol 11, Iss 8, p 1488 (2022)

Macrophages undergo a metabolic switch from oxidative phosphorylation to glycolysis when exposed to gram-negative bacterial lipopolysaccharide (LPS), which modulates antibacterial host defence mechanisms. Here, we show that LPS treatment of macrophag

Externí odkaz: https://doaj.org/article/83b0f2bd21c8471894b47e8cff871b29

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Envisioning nutrition teaching as a three-course meal: a blended approach to knowledge, application and assessment

Autor: Deborah R. Erlich

Publikováno v: Education for Primary Care. 33:352-356

Medical students receive inadequate training in nutrition counselling, but the best way to teach this topic is unknown. To address this research gap, we developed a longitudinal blended programme - combining physical classroom experiences with online

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a16e8352e791016cdff5f69b2b440c
https://doi.org/10.1080/14739879.2022.2137854

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