Výsledky vyhledávání

Leukocyte cathepsin S is a potent regulator of both cell and matrix turnover in advanced atherosclerosis

Autor: E. E. van der Wall, Th.J.C. van Berkel, R de Nooijer, P.J. van Santbrink, R. Dorland, Marijke M. Westra, Guo-Ping Shi, J.H. von der Thüsen, E.A.L. Biessen, Herman S. Overkleeft, A.O. Kraaijeveld, S.H. van Heiningen, Michiel A. Leeuwenburgh, Joop Jukema, Petri T. Kovanen, Ilze Bot

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology, 29(2), 188-194. Lippincott Williams and Wilkins
Arteriosclerosis, thrombosis and vascular biology, 29(2), 188-194. Lippincott Williams & Wilkins

Objective— A dysbalance of proteases and their inhibitors is instrumental in remodeling of atherosclerotic plaques. One of the proteases implicated in matrix degradation is cathepsin-S (CatS). To address its role in advanced lesion composition, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1cfdd062ab4c67cd41bb96da9d0d7f9
https://doi.org/10.1161/atvbaha.108.181578

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Delivery of cholesteryl-conjugated phosphorothioate oligodeoxynucleotides to Kupffer cells by lactosylated low-density lipoprotein

Autor: M K, Bijsterbosch, M, Manoharan, R, Dorland, I H, Waarlo, E A, Biessen, T J, van Berkel

Publikováno v: Biochemical pharmacology. 62(5)

The efficacy of antisense oligonucleotides depends on the ability to reach in vivo their target cells. We aim to develop strategies to enhance uptake of phosphorothioate oligodeoxynucleotides by Kupffer cells. To this end, we conjugated cholesterol t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::801f34e389f80363607657b1db9c99ac
https://pubmed.ncbi.nlm.nih.gov/11585059

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Mechanisms of pharmacologic cardioversion of atrial fibrillation by Class I drugs

Autor: M A, Allessie, M C, Wijffels, R, Dorland

Publikováno v: Journal of cardiovascular electrophysiology. 9

We recently developed a goat model of sustained atrial fibrillation (AF) in which repetitive induction of AF by burst pacing shortened the atrial effective refractory period (AERP) (electrophysiologic remodeling) and progressively prolonged the parox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f062cacc240b86b608222d3a0c2f1bd7
https://pubmed.ncbi.nlm.nih.gov/9727679

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083 Developing and Implementing a Computerised Decision Support System for General Practice in the Netherlands

Autor: R de Groot, M Bouma, M Lugtenberg, D Pasveer, R Dorland, T Kool, Jako S. Burgers

Publikováno v: BMJ Quality & Safety. 22:A38.4-A39

Background The Dutch College of General Practitioners (NHG) has produced almost 100 guidelines. Guideline adherence is on average 70–75%, but varies between general practitioners and between guideline recommendations. A computerised decision suppor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9402e75fd9aced8de640f44e179a551f
https://doi.org/10.1136/bmjqs-2013-002293.114

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