Zobrazeno 1 - 10
of 2 165
pro vyhledávání: '"R, Dobson"'
Autor:
N. B. Karlsson, D. M. Schroeder, L. S. Sørensen, W. Chu, J. Dall, N. H. Andersen, R. Dobson, E. J. Mackie, S. J. Köhn, J. E. Steinmetz, A. S. Tarzona, T. O. Teisberg, N. Skou
Publikováno v:
Earth System Science Data, Vol 16, Pp 3333-3344 (2024)
We present an ice-penetrating radar data set acquired over the Greenland ice sheet by aircraft during the years 1971, 1972, 1974, 1978, and 1979. The data set comprises over 177 000 km of flight lines and contains a wealth of information on the state
Externí odkaz:
https://doaj.org/article/6dc855b246f846b9bf3feeab7f47d490
Autor:
Arya Y Nakhe, Prasanna K Dadi, Jinsun Kim, Matthew T Dickerson, Soma Behera, Jordyn R Dobson, Shristi Shrestha, Jean-Philippe Cartailler, Leesa Sampson, Mark A Magnuson, David A Jacobson
Publikováno v:
eLife, Vol 12 (2024)
The gain-of-function mutation in the TALK-1 K+ channel (p.L114P) is associated with maturity-onset diabetes of the young (MODY). TALK-1 is a key regulator of β-cell electrical activity and glucose-stimulated insulin secretion. The KCNK16 gene encodi
Externí odkaz:
https://doaj.org/article/add61f69979043f080ec8914198063ad
Autor:
R. Whittaker, R. Dobson, C. K. Jin, R. Style, P. Jayathissa, K. Hiini, K. Ross, K. Kawamura, P. Muir, the Waitematā AI Governance Group
Publikováno v:
npj Digital Medicine, Vol 6, Iss 1, Pp 1-7 (2023)
Abstract Artificial Intelligence (AI) is undergoing rapid development, meaning that potential risks in application are not able to be fully understood. Multiple international principles and guidance documents have been published to guide the implemen
Externí odkaz:
https://doaj.org/article/9535e59e59be4b8aa528f338b127c7da
Autor:
Sarah M. Graff, Arya Y. Nakhe, Prasanna K. Dadi, Matthew T. Dickerson, Jordyn R. Dobson, Karolina E. Zaborska, Chloe E. Ibsen, Regan B. Butterworth, Nicholas C. Vierra, David A. Jacobson
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113673- (2024)
Summary: Mitochondrial Ca2+ ([Ca2+]m) homeostasis is critical for β-cell function and becomes disrupted during the pathogenesis of diabetes. [Ca2+]m uptake is dependent on elevations in cytoplasmic Ca2+ ([Ca2+]c) and endoplasmic reticulum Ca2+ ([Ca2
Externí odkaz:
https://doaj.org/article/bafc4693a1fb4df690f3a63ad1e180e7
Autor:
Jordyn R. Dobson, David A. Jacobson
Publikováno v:
Biology, Vol 13, Iss 6, p 379 (2024)
The β-cell workload increases in the setting of insulin resistance and reduced β-cell mass, which occurs in type 2 and type 1 diabetes, respectively. The prolonged elevation of insulin production and secretion during the pathogenesis of diabetes re
Externí odkaz:
https://doaj.org/article/f836267799244632a50c12fa6480f4c7
Autor:
Matthew T. Dickerson, Prasanna K. Dadi, Karolina E. Zaborska, Arya Y. Nakhe, Charles M. Schaub, Jordyn R. Dobson, Nicole M. Wright, Joshua C. Lynch, Claire F. Scott, Logan D. Robinson, David A. Jacobson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Gi/o protein-coupled receptors (Gi/o-GPCRs) limit β-cell insulin secretion by decreasing Ca2+ entry; however, the underlying mechanism has not been identified. Here, the authors show that Gi/o-GPCRs hyperpolarize mouse and human β-cell membrane pot
Externí odkaz:
https://doaj.org/article/eb23a693600e41d29543c852619dfa62
Autor:
F. Matcham, D. Leightley, S. Siddi, F. Lamers, K. White, P. Annas, G. De Girolamo, S. Difrancesco, J.M. Haro, M. Horsfall, A. Ivan, G. Lavelle, Q. Li, F. Lombardini, D. Mohr, V. Narayan, C. Oetzmann, B. Penninx, S. Simblett, S. Bruce, R. Nica, T. Wykes, J. Brasen, I. Myin-Germeys, A. Rintala, P. Conde, R. Dobson, A. Folarin, C. Stewart, Y. Ranjan, Z. Rashid, N. Cummins, N. Manyakov, S. Vairavan, M. Hotopf
Publikováno v:
European Psychiatry, Vol 65, Pp S112-S112 (2022)
Introduction Major Depressive Disorder (MDD) is prevalent, often chronic, and requires ongoing monitoring of symptoms to track response to treatment and identify early indicators of relapse. Remote Measurement Technologies (RMT) provide an exciting o
Externí odkaz:
https://doaj.org/article/3df19806ff0b4990b4f88cf5d10cbf31
Autor:
F. Matcham, C. Barattieri di San Pietro, V. Bulgari, G. de Girolamo, R. Dobson, H. Eriksson, A. A. Folarin, J. M. Haro, M. Kerz, F. Lamers, Q. Li, N. V. Manyakov, D. C. Mohr, I. Myin-Germeys, V. Narayan, Penninx BWJH, Y. Ranjan, Z. Rashid, A. Rintala, S. Siddi, S. K. Simblett, T. Wykes, M. Hotopf, on behalf of the RADAR-CNS consortium
Publikováno v:
BMC Psychiatry, Vol 19, Iss 1, Pp 1-11 (2019)
Abstract Background There is a growing body of literature highlighting the role that wearable and mobile remote measurement technology (RMT) can play in measuring symptoms of major depressive disorder (MDD). Outcomes assessment typically relies on se
Externí odkaz:
https://doaj.org/article/de9d8201712546efaa6ca435113723d8
Autor:
Vitor F Martins, Christopher R Dobson, Maedha Begur, Jesal Parekh, Scott T Ball, Francis Gonzalez, Jan M Hughes-Austin, Simon Schenk
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245594 (2021)
While obesity and insulin resistance are known risk factors for wound complications after total joint arthroplasty (TJA), the biologic causes remain to be elucidated. Recently, neutrophil extracellular trap formation (NETosis) was identified as a med
Externí odkaz:
https://doaj.org/article/473d57937438404f88697861fea8cb8c
Autor:
Gregory R. Dobson
Publikováno v:
Canadian Journal of Anesthesia/Journal canadien d'anesthésie. 70:1-9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::369430722a5211d8d6a838ea6990125e
https://doi.org/10.1007/s12630-022-02367-1
https://doi.org/10.1007/s12630-022-02367-1