Zobrazeno 1 - 10 of 612 pro vyhledávání: '"R, Devlin"'
1
Akademický článek
A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometry
Autor: Nishant K. Singh, Jesus A. Alonso, Jason R. Devlin, Grant L. J. Keller, George I. Gray, Adarsh K. Chiranjivi, Sara G. Foote, Lauren M. Landau, Alyssa G. Arbuiso, Laura I. Weiss, Aaron M. Rosenberg, Lance M. Hellman, Michael I. Nishimura, Brian M. Baker
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
MHC restriction depicts CD4+ T cell activation by MHC-II and CD8A+ by MHC-I, but rare T cells with mismatched MHC restriction have been reported. Here the authors use crystallography to describe features of such a mismatched TCR-MHC interaction and i
Externí odkaz: https://doaj.org/article/0743243588da4db7b9427d68ad78e7b9
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3
Akademický článek
Salmonella enterica serovar Typhimurium chitinases modulate the intestinal glycome and promote small intestinal invasion.
Autor: Jason R Devlin, William Santus, Jorge Mendez, Wenjing Peng, Aiying Yu, Junyao Wang, Xiomarie Alejandro-Navarreto, Kaitlyn Kiernan, Manmeet Singh, Peilin Jiang, Yehia Mechref, Judith Behnsen
Publikováno v: PLoS Pathogens, Vol 18, Iss 4, p e1010167 (2022)
Salmonella enterica serovar Typhimurium (S. Typhimurium) is one of the leading causes of food-borne illnesses worldwide. To colonize the gastrointestinal tract, S. Typhimurium produces multiple virulence factors that facilitate cellular invasion. Chi
Externí odkaz: https://doaj.org/article/7c1ddd316bf94ab9ac64ab2938d17bfa
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5
Akademický článek
Structure Based Prediction of Neoantigen Immunogenicity
Autor: Timothy P. Riley, Grant L. J. Keller, Angela R. Smith, Lauren M. Davancaze, Alyssa G. Arbuiso, Jason R. Devlin, Brian M. Baker
Publikováno v: Frontiers in Immunology, Vol 10 (2019)
The development of immunological therapies that incorporate peptide antigens presented to T cells by MHC proteins is a long sought-after goal, particularly for cancer, where mutated neoantigens are being explored as personalized cancer vaccines. Alth
Externí odkaz: https://doaj.org/article/c4c877b0b1b949df9e3516b65879b8fd
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6
Bacterial Chitinases and Their Role in Human Infection
Autor: Jason R. Devlin, Judith Behnsen
Publikováno v: Infection and Immunity.
It has been widely appreciated that numerous bacterial species express chitinases for the purpose of degrading environmental chitin. However, chitinases and chitin-binding proteins are also expressed by pathogenic bacterial species during infection e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a86947ba6c96ff3c2ad1342dd8bd822
https://doi.org/10.1128/iai.00549-22
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7
Akademický článek
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8
Akademický článek
Cell of Origin Links Histotype Spectrum to Immune Microenvironment Diversity in Non-small-Cell Lung Cancer Driven by Mutant Kras and Loss of Lkb1
Autor: Ashwini S. Nagaraj, Jenni Lahtela, Annabrita Hemmes, Teijo Pellinen, Sami Blom, Jennifer R. Devlin, Kaisa Salmenkivi, Olli Kallioniemi, Mikko I. Mäyränpää, Katja Närhi, Emmy W. Verschuren
Publikováno v: Cell Reports, Vol 18, Iss 3, Pp 673-684 (2017)
Lung cancers exhibit pronounced functional heterogeneity, confounding precision medicine. We studied how the cell of origin contributes to phenotypic heterogeneity following conditional expression of KrasG12D and loss of Lkb1 (Kras;Lkb1). Using proge
Externí odkaz: https://doaj.org/article/4865c03d589649f090200e998d1e2cd4
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