Zobrazeno 1 - 10
of 164
pro vyhledávání: '"R, Derbyshire"'
Autor:
Erin A. Schroeder, Maria Toro-Moreno, Rene Raphemot, Kayla Sylvester, Isabel C. Colón, Emily R. Derbyshire
Publikováno v:
mSphere, Vol 9, Iss 3 (2024)
ABSTRACTThe apicomplexans Toxoplasma gondii and Plasmodium are intracellular parasites that reside within a host-derived compartment termed the parasitophorous vacuole (PV). During infection, the parasites must acquire critical host resources and tra
Externí odkaz:
https://doaj.org/article/050246e423d74f19ae46c9a663525d47
Autor:
Mark A. Tye, N. Connor Payne, Catrine Johansson, Kritika Singh, Sofia A. Santos, Lọla Fagbami, Akansha Pant, Kayla Sylvester, Madeline R. Luth, Sofia Marques, Malcolm Whitman, Maria M. Mota, Elizabeth A. Winzeler, Amanda K. Lukens, Emily R. Derbyshire, Udo Oppermann, Dyann F. Wirth, Ralph Mazitschek
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The development of antimalarials against the human liver and asexual blood stages is one of the top public health challenges. Here, the authors report a single-step biochemical assay for the characterization of prolyl-tRNA synthetase inhibitors, and
Externí odkaz:
https://doaj.org/article/67e7e347e61b426e9ad816c4a19d8f56
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104608- (2022)
Externí odkaz:
https://doaj.org/article/73337981ad9d401b9ca76a975627f563
Autor:
Sangsu Bang, Christopher R. Donnelly, Xin Luo, Maria Toro-Moreno, Xueshu Tao, Zilong Wang, Sharat Chandra, Andrey V. Bortsov, Emily R. Derbyshire, Ru-Rong Ji
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
GPR37 is expressed in macrophages, and has been implicated in resolution of inflammatory pain. Here the authors show that GPR37 can modulate sepsis in several animal models.
Externí odkaz:
https://doaj.org/article/eb825ea936f54c5198d6ef87a574a599
Autor:
Kayla Sylvester, Steven P. Maher, Dora Posfai, Michael K. Tran, McKenna C. Crawford, Amélie Vantaux, Benoît Witkowski, Dennis E. Kyle, Emily R. Derbyshire
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Plasmodium is a genus of apicomplexan parasites which replicate in the liver before causing malaria. Plasmodium vivax can also persist in the liver as dormant hypnozoites and cause clinical relapse upon activation, but the molecular mechanisms leadin
Externí odkaz:
https://doaj.org/article/eb61cd7ba2e44e8685764525ca944d4d
Publikováno v:
ACS Chemical Biology. 18:785-793
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e8914234bd2d10999e58a4dc8080b49
https://doi.org/10.1021/acschembio.2c00783
https://doi.org/10.1021/acschembio.2c00783
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT The apicomplexan parasites Plasmodium spp. are the causative agents of malaria, a disease that poses a significant global health burden. Plasmodium spp. initiate infection of the human host by transforming and replicating within hepatocytes.
Externí odkaz:
https://doaj.org/article/453cc204e3344120afb0e2bde561d652
Autor:
E. K. Studd, M. J. L. Peers, A. K. Menzies, R. Derbyshire, Y. N. Majchrzak, J. L. Seguin, D. L. Murray, B. Dantzer, J. E. Lane, A. G. McAdam, M. M. Humphries, S. Boutin
Publikováno v:
Oecologia. 200:349-358
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdcc50fe4343964fb972888627d2231e
https://doi.org/10.1007/s00442-022-05266-w
https://doi.org/10.1007/s00442-022-05266-w
Autor:
Kareem A. Galal, Anna Truong, Frank Kwarcinski, Chandi de Silva, Krisha Avalani, Tammy M. Havener, Michael E. Chirgwin, Eric Merten, Han Wee Ong, Caleb Willis, Ahmad Abdelwaly, Mohamed A. Helal, Emily R. Derbyshire, Reena Zutshi, David H. Drewry
Publikováno v:
Journal of Medicinal Chemistry. 65:13172-13197
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9157dae09bb16f8beecc10edc94755ec
https://doi.org/10.1021/acs.jmedchem.2c00996
https://doi.org/10.1021/acs.jmedchem.2c00996
Autor:
Aaron M. Keeler, Porter E. Petruzziello, Elizabeth G. Boger, Hannah K. D’Ambrosio, Emily R. Derbyshire
Polyketide synthases (PKSs) are megaenzymes that form chemically diverse polyketides and are found within the genomes of nearly all classes of life. We recently discovered the type I PKS from the apicomplexan parasiteToxoplasma gondii, TgPKS2, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98353adc521507e6c0a254461b98c15a
https://doi.org/10.1101/2023.05.23.541938
https://doi.org/10.1101/2023.05.23.541938
