Zobrazeno 1 - 10
of 9 702
pro vyhledávání: '"R, Davies"'
Autor:
Shadi Basyuni, Laura Heskin, Andrea Degasperi, Daniella Black, Gene C. C. Koh, Lucia Chmelova, Giuseppe Rinaldi, Steven Bell, Louise Grybowicz, Greg Elgar, Yasin Memari, Pauline Robbe, Zoya Kingsbury, Carlos Caldas, Jean Abraham, Anna Schuh, Louise Jones, PARTNER Trial Group, Personalised Breast Cancer Program Group, Marc Tischkowitz, Matthew A. Brown, Helen R. Davies, Serena Nik-Zainal
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Whole genome sequencing (WGS) provides comprehensive, individualised cancer genomic information. However, routine tumour biopsies are formalin-fixed and paraffin-embedded (FFPE), damaging DNA, historically limiting their use in WGS. Here we
Externí odkaz:
https://doaj.org/article/1788544aae364aa680930fe83e4b04ab
Autor:
Tayyaba Malik, MD, Robert Douglas B. Jaquiss, MD, Omar Harirah, MD, Ryan R. Davies, MD, Nicholas Andersen, MD, Steven Leonard, MD, Song Zhang, PhD, Karl M. Reyes, MD
Publikováno v:
Annals of Thoracic Surgery Short Reports, Vol 2, Iss 3, Pp 359-363 (2024)
Background: In small children with left atrioventricular valve dysfunction, valve repair is preferred but some will require valve replacement. No prosthetic valve has growth potential, bioprostheses have poor durability, and mechanical prostheses hav
Externí odkaz:
https://doaj.org/article/a29243388e5644d39b12a82fa0c3a8ed
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract DNA double-strand break repair by homologous recombination has a specialised role in meiosis by generating crossovers that enable the formation of haploid germ cells. This requires meiosis-specific MEILB2-BRME1, which interacts with BRCA2 to
Externí odkaz:
https://doaj.org/article/0eb8de457b214548be6a39e0ed5cfd51
Autor:
Andrew R. Davies, Sanjeeve Sabharwal, Peter Reilly, R. A. Sankey, Dylan Griffiths, Stephanie Archer
Publikováno v:
Bone & Joint Open, Vol 5, Iss 7, Pp 543-549 (2024)
Aims: Shoulder arthroplasty is effective in the management of end-stage glenohumeral joint arthritis. However, it is major surgery and patients must balance multiple factors when considering the procedure. An understanding of patients’ decision-mak
Externí odkaz:
https://doaj.org/article/980ece8435ef4c82a627252309cbcdbe
Publikováno v:
Geoscientific Model Development, Vol 17, Pp 5057-5086 (2024)
Reconstructing the thermo-chemical evolution of Earth's mantle and its diverse surface manifestations is a widely recognised grand challenge for the geosciences. It requires the creation of a digital twin: a digital representation of Earth's mantle a
Externí odkaz:
https://doaj.org/article/84fad2359d294cc0b2f1a873087c39d9
Autor:
Ouli Xie, Cameron Zachreson, Gerry Tonkin-Hill, David J. Price, Jake A. Lacey, Jacqueline M. Morris, Malcolm I. McDonald, Asha C. Bowen, Philip M. Giffard, Bart J. Currie, Jonathan R. Carapetis, Deborah C. Holt, Stephen D. Bentley, Mark R. Davies, Steven Y. C. Tong
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Streptococcus dysgalactiae subspecies equisimilis (SDSE) and Streptococcus pyogenes share skin and throat niches with extensive genomic homology and horizontal gene transfer (HGT) possibly underlying shared disease phenotypes. It is unknown
Externí odkaz:
https://doaj.org/article/42a9dffb6c3c4679a54672606334ce30
Autor:
Joseph A. Bell, Elizabeth R. Davies, Christopher J. Brereton, Milica Vukmirovic, James J.W. Roberts, Kerry Lunn, Leanne Wickens, Franco Conforti, Robert A. Ridley, Jessica Ceccato, Lucy N. Sayer, David A. Johnston, Andres F. Vallejo, Aiman Alzetani, Sanjay Jogai, Ben G. Marshall, Aurelie Fabre, Luca Richeldi, Phillip D. Monk, Paul Skipp, Naftali Kaminski, Emily Offer, Yihua Wang, Donna E. Davies, Mark G. Jones
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101695- (2024)
Summary: Matrix stiffening by lysyl oxidase-like 2 (LOXL2)-mediated collagen cross-linking is proposed as a core feedforward mechanism that promotes fibrogenesis. Failure in clinical trials of simtuzumab (the humanized version of AB0023, a monoclonal
Externí odkaz:
https://doaj.org/article/28bf070de21f4af1b6319da757012509
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 8 (2024)
ABSTRACT Bacterial species often consist of strains with variable gene content, collectively referred to as the pangenome. Variations in the genetic makeup of strains can alter bacterial physiology and fitness. To define biologically relevant genes o
Externí odkaz:
https://doaj.org/article/ccd8ca9ba7da4bce9ae862985274c7b2
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 7 (2024)
ABSTRACT In nature, bacteria usually exist as mixed-species biofilms, where they engage in a range of synergistic and antagonistic interactions that increase their resistance to environmental challenges. Biofilms are a major cause of persistent infec
Externí odkaz:
https://doaj.org/article/6d4ab0dcdeb0470b90ff999582666039
Autor:
Chelisa Cardinez, Yuwei Hao, Kristy Kwong, Ainsley R. Davies, Morgan B. Downes, Nadia A. Roberts, Jason D. Price, Raquel A. Hernandez, Jessica Lovell, Rochna Chand, Zhi-Ping Feng, Anselm Enders, Carola G. Vinuesa, Bahar Miraghazadeh, Matthew C. Cook
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Loss-of-function mutations have provided crucial insights into the immunoregulatory actions of Foxp3+ regulatory T cells (Tregs). By contrast, we know very little about the consequences of defects that amplify aspects of Treg function or dif
Externí odkaz:
https://doaj.org/article/db07c536c7a44f49859f6963437bbf1a