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Akademický článek

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Autor: R. Cowherd, Kamal K. Mittal, R. Kumar, D. M. Wong, N. Sansonetii, S. Naik

Publikováno v: Tissue Antigens. 20:223-226

This study reports the phenotype frequencies (PF) and gene frequencies (GF) of 72 different HLA-A, -B, -C, and -DR antigens in Indian Hindus, thus substantially extending the data previously reported for Asian Indians (Singal 1972, Bale et al. 1980,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693fc69cd60755da2ccd94f50b349607
https://doi.org/10.1111/j.1399-0039.1982.tb00349.x

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Improved Gene Transfer into Human Lymphocytes Using Retroviruses with the Gibbon Ape Leukemia Virus Envelope

Autor: R Cowherd, Patrick Hwu, Steven A. Rosenberg, John S. Lam, Mark E. Reeves

Publikováno v: Human Gene Therapy. 7:1415-1422

Gene-modified lymphocytes have a potential role in the therapy of cancer, infectious diseases, and genetic disorders of the immune system. Current gene therapy protocols involving gene transfer into lymphocytes utilize retroviruses with amphotropic e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df294b560d1f81f49df66c4d1fd5e70
https://doi.org/10.1089/hum.1996.7.12-1415

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Interleukin-2-transduced lymphocytes grow in an autocrine fashion and remain responsive to antigen

Autor: Richard A. Morgan, Steven A. Rosenberg, R Cowherd, G. E. Shafer, Seijiro Minamoto, Patrick Hwu, J. Treisman

Publikováno v: Blood. 85:139-145

The maintenance of T lymphocytes in vivo after adoptive transfer for immunotherapy requires the systemic administration of interleukin-2 (IL- 2), but prolonged administration of IL-2 is associated with substantial toxicity. The constitutive productio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73afd27f85450438ef81092f641e581b
https://doi.org/10.1182/blood.v85.1.139.bloodjournal851139

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Functional and molecular characterization of tumor-infiltrating lymphocytes transduced with tumor necrosis factor-alpha cDNA for the gene therapy of cancer in humans

Autor: P Hwu, J Yannelli, M Kriegler, W F Anderson, C Perez, Y Chiang, S Schwarz, R Cowherd, C Delgado, J Mulé

Publikováno v: The Journal of Immunology. 150:4104-4115

TNF is effective in causing the regression of selected murine tumors when administered at high concentrations. Therapeutic levels in humans cannot be obtained systemically, however, because of dose-limiting toxicity. The development of immunotherapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8fe37177e90403cc338d0881170cd849
https://doi.org/10.4049/jimmunol.150.9.4104

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Akademický článek

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In vivo antitumor activity of T cells redirected with chimeric antibody/T-cell receptor genes

Autor: P, Hwu, J C, Yang, R, Cowherd, J, Treisman, G E, Shafer, Z, Eshhar, S A, Rosenberg

Publikováno v: Cancer research. 55(15)

In an effort to broaden the applicability of adoptive cellular immunotherapy toward nonmelanoma cancers, we have designed chimeric antibody/T-cell receptor genes composed of the variable domains from mAbs joined to T-cell receptor-signaling chains. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4633c1c07ce10e43388524044adc8125
https://pubmed.ncbi.nlm.nih.gov/7614473

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Interleukin-2-transduced lymphocytes grow in an autocrine fashion and remain responsive to antigen

Autor: J, Treisman, P, Hwu, S, Minamoto, G E, Shafer, R, Cowherd, R A, Morgan, S A, Rosenberg

Publikováno v: Blood. 85(1)

The maintenance of T lymphocytes in vivo after adoptive transfer for immunotherapy requires the systemic administration of interleukin-2 (IL-2), but prolonged administration of IL-2 is associated with substantial toxicity. The constitutive production

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c823595d09d69002c750727fe578955a
https://pubmed.ncbi.nlm.nih.gov/7803791

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Upregulation of tumor necrosis factor-alpha production by retrovirally transduced human tumor-infiltrating lymphocytes using trans-retinoic acid

Autor: Patrick Hwu, R Cowherd, J. Treisman, G. E. Shafer, John R. Yannelli, Steven A. Rosenberg, Dvorit Samid

Publikováno v: Cellular immunology. 156(2)

The ability of retinoic acid (RA) to upregulate gene expression in human tumor-infiltrating lymphocytes (TIL) transduced with a Moloney murine leukemia virus containing the cDNA encoding tumor necrosis factor (TNF) has been studied. TNF production wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e130a85757c687b907fd8850ea3fc676
https://pubmed.ncbi.nlm.nih.gov/8025957

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Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain

Autor: Steven A. Rosenberg, J. Treisman, Daniel Schindler, G. E. Shafer, R Cowherd, Zelig Eshhar, Gideon Gross, P Hwu

Publikováno v: The Journal of Experimental Medicine

To expand the spectrum of recognition of effector lymphocytes and to redirect them towards predefined targets, we have altered the specificity of human tumor-infiltrating lymphocytes (TIL) through stable modification with chimeric receptor genes cons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad0a7ec69a0a12c52c392fb88ad868e
https://pubmed.ncbi.nlm.nih.gov/8315392

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