Výsledky vyhledávání - "R, Charubala"

ChemInform Abstract: Chemical Synthesis of 2′,5′-Oligoadenylate Analogues

Autor: W. Pfleiderer, R. Charubala

Publikováno v: ChemInform. 26

The interferons (IFN) are a family of proteins secreted by mammalian cells in response to various inducers (Baglioni 1979; Revel 1979; Stewart 1979; Friedman 1981; Pestka 1981; Torrence 1982; Sehgal et al. 1983). The interferons are divided into thre

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https://doi.org/10.1002/chin.199504292

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Inhibition of growth of estrogen receptor positive and estrogen receptor negative breast cancer cells in culture by AA-etherA, a stable 2-5A derivative

Autor: K E, Latham, S, Cosenza, N L, Reichenbach, E, Mordechai, M E, Adelson, N, Kon, S E, Horvath, R, Charubala, S N, Mikhailov, W, Pfeiderer, R J, Suhadolnik

Publikováno v: Oncogene. 12(4)

The design, chemical synthesis and biological activities of a nuclease-resistant, nontoxic bioactive 2-5A derivative, AA-etherA [i.e., adenylyl-(2'-5')-adenylyl-(2'-2")-9-[(2'-hydroxyethoxy)-methyl]adenine], are described as a new approach to the inh

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https://pubmed.ncbi.nlm.nih.gov/8632905

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Chemical Synthesis of 2′,5′-0ligoadenylate Analogues

Autor: W. Pfleiderer, R. Charubala

Publikováno v: Biological Response Modifiers — Interferons, Double-Stranded RNA and 2′,5′-Oligoadenylates ISBN: 9783642785511

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https://doi.org/10.1007/978-3-642-78549-8_7

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Chemical synthesis of 2',5'-oligoadenylate analogues

Autor: R, Charubala, W, Pfleiderer

Publikováno v: Progress in molecular and subcellular biology. 14

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https://pubmed.ncbi.nlm.nih.gov/7520327

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Specificities of rabbit anti-(2',5')oligoadenylate antibodies towards phosphorothioate and seco analogs of oligoadenylates

Autor: I A, Mikhailopulo, E I, Kvasyuk, T I, Kulak, S M, Shulyakovskaya, M V, Makarenko, S N, Mikhailov, R, Charubala, W, Pfleiderer

Publikováno v: Nucleic acids symposium series. (24)

Rabbit antibodies to 2',5'-linked triadenylate were prepared by immunization with (2',5')A3 conjugated via the 2'3'-levulinic group, (2'5')A3-Lev, to BSA. New radioimmunoassay for (2',5')oligoadenylates was developed using 125I thyrosine labeled deri

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https://pubmed.ncbi.nlm.nih.gov/1841383

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2',5'-Oligoadenylate trimer core and the cordycepin analog augment the tumoricidal activity of human natural killer cells

Autor: P L Black, E E Henderson, W Pfleiderer, R Charubala, R J Suhadolnik

Publikováno v: The Journal of Immunology. 133:2773-2777

Interferon (IFN) augments the lytic activity of natural killer (NK) cells, inhibits the transformation of human peripheral blood lymphocytes (PBL) by Epstein Barr virus (EBV), and induces a 2',5'-oligoadenylate (2',5'-An) synthetase. Exogenous 2',5'-

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https://doi.org/10.4049/jimmunol.133.5.2773

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Studies on the syntheses of heterocyclic compounds—CDLXVII

Autor: R. Charubala, Keiichiro Fukumoto, T. Kohno, Tetsuji Kametani

Publikováno v: Tetrahedron. 28:3227-3231

Photolysis of 1-(2-bromo-3-hydroxy-4-methoxyphenethyl)-1,2,3,4-tetrahydro-7-hydroxy-6-methoxy-2-methylisoquinoline (10) gave the kreysiginine-type enone 12 in addition to the thalifoline (11). Phenolic oxidation of 10 gave a para-para coupling produc

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https://doi.org/10.1016/s0040-4020(01)93663-4

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Synthesis and characterization of deoxy- and ribo H-phosphonate dimers

Autor: A, Jäger, R, Charubala, W, Pfleiderer

Publikováno v: Nucleic acids symposium series. (18)

Various nucleoside-3'-H-phosphonates of the deoxy and ribo series were synthesized and condensed with a second nucleoside to give the corresponding H-phosphonate dimers. The solution syntheses give high yields and the products have been characterized

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https://pubmed.ncbi.nlm.nih.gov/3697127

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