Astrocytes are mainly responsible for the polyunsaturated fatty acid enrichment in blood–brain barrier endothelial cells in vitro

Autor: N. Bernoud, L. Fenart, C. Bénistant, J.F. Pageaux, M.P. Dehouck, P. Molière, M. Lagarde, R. Cecchelli, J. Lecerf

Publikováno v: Journal of Lipid Research, Vol 39, Iss 9, Pp 1816-1824 (1998)

To determine the respective roles of endothelial cells from brain capillaries and astrocytes in the conversion of circulating 18:2n–6 and 18:3n–3 into 20:4n–6 and 22:6n–3, respectively, a coculture of the two cell types mimicking the in vivo

Externí odkaz: https://doaj.org/article/4f5bcfa2da8f471ca47699612f8171f7

A Simple Method for Assessing Free Brain/Free Plasma Ratios Using an In Vitro Model of the Blood Brain Barrier

Autor: Emmanuel Sevin, Stefan Martinsson, Stefan Lundquist, Maxime Culot, Erica Szorath, Anaelle da Costa, Yan Hongmei, Mila Renftel, R. Cecchelli

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2013, 8 (12), pp.e80634. ⟨10.1371/journal.pone.0080634⟩
PLoS ONE, Vol 8, Iss 12, p e80634 (2013)

International audience; Historically, the focus has been to use in vitro BBB models to optimize rate of drug delivery to the CNS, whereas total in vivo brain/plasma ratios have been used for optimizing extent. However, these two parameters do not nec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86c385cb5c608e1e225ea0f7276d3a8
https://hal-univ-artois.archives-ouvertes.fr/hal-02515332

In vitro blood–brain barrier model adapted to repeated-dose toxicological screening

Autor: C. Landry, R. Aijjou, Maxime Culot, R. Cecchelli, A. Fabulas-da Costa, Johan Hachani

Publikováno v: Toxicology in Vitro
Toxicology in Vitro, Elsevier, 2013, 27 (6), pp.1944-1953. ⟨10.1016/j.tiv.2013.06.026⟩
Toxicology in Vitro; Vol 27

International audience; Toxicity to the central nervous system (CNS) is a key feature in the toxicological profile of compounds and there is a growing interest to use in vitro cell assays. The blood-brain barrier (BBB) is a highly restrictive barrier

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c3dd0ef207a7b73414bdf87a90098b6
https://hal-univ-artois.archives-ouvertes.fr/hal-02515342

Glial-cell-mediated re-induction of the blood-brain barrier phenotype in brain capillary endothelial cells: A differential gel electrophoresis study

Autor: Philippe Chafey, Cédric Broussard, Yannis Karamanos, Barbara Deracinois, Gwënaël Pottiez, Luc Camoin, Tom Teerlink, Pierre-Olivier Couraud, R. Cecchelli, Christophe Flahaut, Mariska Davids, Marie-Pierre Dehouck

Publikováno v: Proteomics
Proteomics, Wiley-VCH Verlag, 2013, 13 (7), pp.1185-1199. ⟨10.1002/pmic.201200166⟩
Journal of Proteomics, 13(7), 1185-1199. Elsevier
Deracinois, B, Pottiez, G, Chafey, P, Teerlink, T, Camoin, L, Davids, M, Broussard, C, Couraud, P O, Dehouck, M P, Cecchelli, R, Karamanos, Y & Flahaut, C 2013, ' Glial-cell-mediated re-induction of the blood-brain barrier phenotype in brain capillary endothelial cells: A differential gel electrophoresis study ', Journal of Proteomics, vol. 13, no. 7, pp. 1185-1199 . https://doi.org/10.1002/pmic.201200166
PROTEOMICS; Vol 13
PROTEOMICS

International audience; In the neurovascular unit, brain microvascular endothelial cells develop characteristic barrier features that control the molecular exchanges between the blood and the brain. These characteristics are partially or totally lost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af830746f17660dcb109e1b7d12b9b7e
https://hal-univ-artois.archives-ouvertes.fr/hal-02515850

Increased transendothelial permeability of anti-cancer agent carboplatin with the aid of hyperbaric oxygenation

Autor: S Nion, Norie Murayama, Hiroshi Yamazaki, Makiko Shimizu, K Tanaka, R Cecchelli

Publikováno v: Xenobiotica
Xenobiotica, Taylor & Francis, 2008, 38 (10), p. 1298-1304

International audience; 1. The objective was to investigate the transport of an anticancer agent carboplatin across the blood-brain barrier in combination with hyperbaric oxygenation treatment. An in vitro well-validated model of bovine brain capilla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca78d7fbb0f86b0332bf1e4131d4403a
https://hal-univ-artois.archives-ouvertes.fr/hal-00543660