Zobrazeno 1 - 10
of 308
pro vyhledávání: '"R, Brockman"'
Autor:
Qierra R. Brockman, Amanda Scherer, Gavin R. McGivney, Wade R. Gutierrez, Jeffrey Rytlewski, Alexa Sheehan, Akshaya Warrier, Emily A. Laverty, Grace Roughton, Nina C. Carnevale, Vickie Knepper-Adrian, Rebecca D. Dodd
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract CRISPR/Cas9 gene editing has evolved from a simple laboratory tool to a powerful method of in vivo genomic engineering. As the applications of CRISPR/Cas9 technology have grown, the need to characterize the breadth and depth of indels genera
Externí odkaz:
https://doaj.org/article/36c28b8809a147058959426b72e59f6f
Autor:
Wade R. Gutierrez, Jeffrey D. Rytlewski, Amanda Scherer, Grace A. Roughton, Nina C. Carnevale, Krisha Y. Vyas, Gavin R. McGivney, Qierra R. Brockman, Vickie Knepper-Adrian, Rebecca D. Dodd
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 2, Pp 1218-1232 (2023)
Rhabdomyosarcoma (RMS) is an aggressive form of cancer that accounts for half of all pediatric soft tissue sarcomas. Little progress has been made in improving survival outcomes over the past three decades. Mouse models of rhabdomyosarcoma are a crit
Externí odkaz:
https://doaj.org/article/aadfd4285500410b8d0e896539fe86c7
Autor:
Wade R. Gutierrez, Amanda Scherer, Jeffrey D. Rytlewski, Emily A. Laverty, Alexa P. Sheehan, Gavin R. McGivney, Qierra R. Brockman, Vickie Knepper-Adrian, Grace A. Roughton, Dawn E. Quelle, David J. Gordon, Varun Monga, Rebecca D. Dodd
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
The DNA methyltransferase inhibitor decitabine has classically been used to reactivate silenced genes and as a pretreatment for anticancer therapies. In a variation of this idea, this study explores the concept of adding low-dose decitabine (DAC) fol
Externí odkaz:
https://doaj.org/article/f1f2ba4470e1443796a237d00e963599
Autor:
Qierra R. Brockman, Amanda Scherer, Gavin R. McGivney, Wade R. Gutierrez, Andrew P. Voigt, Alexandra L. Isaacson, Emily A. Laverty, Grace Roughton, Vickie Knepper-Adrian, Benjamin Darbro, Munir R. Tanas, Christopher S. Stipp, Rebecca D. Dodd
Publikováno v:
JCI Insight, Vol 7, Iss 20 (2022)
The histone methyltransferase PRC2 plays a complex role in cancer. Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas with frequent loss-of-function mutations in PRC2 that are associated with poor outcome. Here, we identify a c
Externí odkaz:
https://doaj.org/article/72aae0cfd35e4271a50d462f47391a87
Autor:
Wade R. Gutierrez, Amanda Scherer, Gavin R. McGivney, Qierra R. Brockman, Vickie Knepper-Adrian, Emily A. Laverty, Grace A. Roughton, Rebecca D. Dodd
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Immune cells play critical functions in cancer, and mice with intact immune systems are vital to understanding tumor immunology. Both genetically engineered mouse models (GEMMs) and syngeneic cell transplant approaches use immunocompetent mi
Externí odkaz:
https://doaj.org/article/8c80128f3ad64d2eaaee4e5ea0d6de23
Publikováno v:
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-12 (2019)
Abstract Multiple myeloma (MM) is the second most common hematologic malignancy and remains incurable despite the advent of numerous new drugs such as proteasome inhibitors (PIs), immunomodulatory agents (IMiDs), and monoclonal antibodies. There is a
Externí odkaz:
https://doaj.org/article/d5273e61a05c4f8899ce427199920b24
Akademický článek
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Autor:
J White, A Nicholson, D Ward, R Campbell, C Metcalfe, R Kipping, R Jago, A Papadaki, W Hollingworth, S Wells, R Brockman, L Moore
Publikováno v:
BMJ Open, Vol 6, Iss 4 (2016)
Introduction Systematic reviews have identified the lack of intervention studies with young children to prevent obesity. This feasibility study examines the feasibility and acceptability of adapting the Nutrition and Physical Activity Self-Assessment
Externí odkaz:
https://doaj.org/article/1c7f0d3c7e6946c7a8bb349a0ce32c2d
Publikováno v:
Cancer Drug Resistance.
Sarcomas are a class of rare malignancies of mesenchymal origin with a heterogeneous histological spectrum. They are classically associated with poor outcomes, especially once metastasized. A path to improving clinical outcomes may be made through mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::797c26dfa648a2e8df2173440f83468b
https://doi.org/10.20517/cdr.2021.88
https://doi.org/10.20517/cdr.2021.88
Autor:
Qierra R. Brockman, Amanda Scherer, Gavin R. McGivney, Wade R. Gutierrez, Andrew Voigt, Alexandra Isaacson, Emily A. Laverty, Grace Roughton, Vickie Knepper-Adrian, Benjamin Darbro, Munir R. Tanas, Christopher Stipp, Rebecca D. Dodd
Publikováno v:
Cancer Research. 82:A024-A024
Epigenetic reprogramming alters gene transcription in response to different cellular cues and can occur at both the DNA level as well as histone post-translational modifications. Polycomb repressive complex 2 (PRC2) is a common epigenetic modifier th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26da66e5b7f6b85d678f07a6c51b07ec
https://doi.org/10.1158/1538-7445.cancepi22-a024
https://doi.org/10.1158/1538-7445.cancepi22-a024