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Akademický článek

Clinical Phenotype and Outcomes of Indo-Asian Patients with ANCA-Associated Glomerulonephritis in the North West, UK

Autor: Lauren Floyd, Joshua Storrar, Sanjeev Pramanik, Adam D. Morris, Smeeta Sinha, Silke R. Brix, Philip A. Kalra, Ajay P. Dhaygude

Publikováno v: Kidney and Dialysis, Vol 3, Iss 4, Pp 335-345 (2023)

ANCA-associated vasculitides (AAV) are rare, autoimmune conditions associated with end-stage kidney disease (ESKD) and mortality. Data have predominately been from White populations of European ancestry although geographical differences are well docu

Externí odkaz: https://doaj.org/article/a4a8bb3a24dd4865a36cd6e783ab47ea

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Akademický článek

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Akademický článek

The 13th International Podocyte Conference

Autor: Silke R. Brix, Durga A.K. Kanigicherla, Dean Wallace, Tejas Desai, Rachel Lennon

Publikováno v: Glomerular Diseases, Vol 2, Iss 1, Pp 1-78 (2022)

Externí odkaz: https://doaj.org/article/e9679bf2babd49ef96532d7420cbcd97

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Akademický článek

Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies

Autor: Sarah Irmscher, Silke R. Brix, Svante L. H. Zipfel, Luke D. Halder, Sibel Mutlutürk, Sonia Wulf, Evaldas Girdauskas, Hermann Reichenspurner, Rolf A. K. Stahl, Berit Jungnickel, Thorsten Wiech, Peter F. Zipfel, Christine Skerka

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

FHR1 is a serum protein implicated in complement regulation. Here the authors show that human FHR1 binds to necrotic cells, triggering inflammasome activation in monocytes in culture, localizes to necrotic tissue and correlates with inflammatory cyto

Externí odkaz: https://doaj.org/article/37aad357dc58436e9dd86d7bd2bd62bb

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ANCA Vasculitis Induction Management During the COVID-19 Pandemic

Publikováno v: Kidney International Reports

As the severe acute respiratory syndrome coronavirus 2 pandemic evolved and became a global health threat, the safety of immunosuppression in antineutrophil cytoplasmic antibody-associated vasculitis (AAV) became of utmost important for clinicians an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c183df64bafe9f1bc199043fd57525c
https://doi.org/10.1016/j.ekir.2021.08.009

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Risk Factors for Severe Outcomes in Patients With Systemic Vasculitis and COVID‐19: A Binational, Registry‐Based Cohort Study

Autor: Jennifer Scott, Stephen P. McAdoo, Mark A. Little, David Jayne, Matthew A Rutherford, Rona M Smith, Maira Karabayas, D. Gray, Seerapani Gopaluni, Marilina Antonelou, Neeraj Dhaun, Neil Basu, Silke R. Brix, Colin C. Geddes, Alan D. Salama, Raashid Luqmani, Joe Barrett

Publikováno v: Arthritis & Rheumatology (Hoboken, N.j.)

Objective COVID-19 is a novel infectious disease with a broad spectrum of clinical severity. Patients with systemic vasculitis have an increased risk of serious infections and may be at risk of severe outcomes following COVID-19. We undertook this st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5195023e5972faf7eaf2892f3965cb1e
https://doi.org/10.1002/art.41728

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