Zobrazeno 1 - 10
of 38
pro vyhledávání: '"R, Brickl"'
Publikováno v:
Scopus-Elsevier
Using acetylsalicylic acid-dipyridamole, a combined thromboxane receptor antagonist-thromboxane synthase inhibitor, and a fibrinogen receptor antagonist as examples, this article discusses the predictive value of several methods that may be employed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31f0d9428c21bcd1010cffb6ca7e16a
https://doi.org/10.1177/009127009703700123
https://doi.org/10.1177/009127009703700123
Publikováno v:
British Journal of Clinical Pharmacology. 30:179-186
1. In a randomized, double-blind trial we compared the inhibition of the platelet-vessel wall interactions in whole blood ex vivo. There were four groups of 24 healthy volunteers each of whom were treated orally for 3.5 days with either 200 mg dipyri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6643f83a788ade6b3ce1a8f76b93a396
https://doi.org/10.1111/j.1365-2125.1990.tb03763.x
https://doi.org/10.1111/j.1365-2125.1990.tb03763.x
Publikováno v:
International journal of clinical pharmacology and therapeutics. 35(10)
In clinical studies, pharmacodynamic effects should be achieved, e.g. maintenance of certain effects with reversibly acting drugs. Available data base for early phase II studies is frequently kinetics in healthy volunteers from phase I studies and ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4b21ed6d8185db444362054888d35abf
https://pubmed.ncbi.nlm.nih.gov/9352399
https://pubmed.ncbi.nlm.nih.gov/9352399
Autor:
H, von Nicolai, R, Brickl, H, Eschey, A, Greischel, G, Heinzel, E, König, J, Limmer, E, Rupprecht
Publikováno v:
Arzneimittel-Forschung. 47(3)
The duration of action and the pharmacokinetics of gliquidone (1-cyclohexyl-3-[[4-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1, 3-dioxo-2(1H)-isochinolyl)ethyl]phenyl]-sulfonyl]-urea, AR-DF 26 SE, CAS 33342-05-1, Glurenorm, Beglynor) were investigated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da285ffaf62a8edbe0774cbacf4fa158
https://pubmed.ncbi.nlm.nih.gov/9105542
https://pubmed.ncbi.nlm.nih.gov/9105542
Publikováno v:
Pharmakodynamische Modelle für die Arzneimittelentwicklung ISBN: 9783642502309
Fur potente Substanzen mussen in der klinischen Prufung adaquate Mesmethoden zur Verfugung gestellt werden. Es wurde eine Methode entwickelt, um den zeitlichen Verlauf eines Mesparameters und damit den Effekt einer Substanz zu beschreiben. Die Aufgab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d6b4b0d48127e3e35030cf4d3dead1e
https://doi.org/10.1007/978-3-642-50229-3_28
https://doi.org/10.1007/978-3-642-50229-3_28
Publikováno v:
Clinical Pharmacology & Therapeutics. 65:165-165
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d91a331fcd5d8ce16faf67818933797
https://doi.org/10.1016/s0009-9236(99)80191-x
https://doi.org/10.1016/s0009-9236(99)80191-x
Publikováno v:
Drug and Chemical Toxicology. 12:21-37
Male and female cynomolgous monkeys were administered 0, 2, 6 or 18 mg/kg 8-methoxypsoralen (8-MOP) 3 times a week orally for 26 consecutive weeks. Dose-dependent emesis was the most sensitive indicator of 8-MOP toxicity. The lowest dose to elicit em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd928e06c620800d875d76f841a6a2a0
https://doi.org/10.3109/01480548908999140
https://doi.org/10.3109/01480548908999140
Publikováno v:
National Cancer Institute monograph. 66
We discovered a strong but saturable first-pass effect after oral administration of psoralens by using different doses and simultaneous or timed application of stable isotopes. Therefore, small variations of dose, disintegration of drug, and amount a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0cc8ae6a66f5fe028a41abe833702859
https://pubmed.ncbi.nlm.nih.gov/6531040
https://pubmed.ncbi.nlm.nih.gov/6531040
Publikováno v:
XIth International Congress on Thrombosis and Haemostasis.
Dipyridamole is widely used as a platelet function inhibiting drug. It is effective in some animal thrombosis models.In healthy volunteers we studied the plasma levels after ingestion of 2 x 75 mg Dipyridamole using a fluorometric assay.We found a la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd4c9e25fc1b70acff65dfeb0bc8fa4b
https://doi.org/10.1055/s-0038-1644825
https://doi.org/10.1055/s-0038-1644825
Autor:
W. Klaubert, C.-H. Bushe, R. Hafter, R. Gollwitzer, W. Wilmanns, H. Graeff, T. H. Schöndorf, L. Witt, H. Pralle, A. Jobke, D. Heinrich, T. Scharf, S. Santoso, C. Mueller-Eckhardt, C. M. Kirchmaier, I. Arnold, D. Rosenthal, R. Brickl, H. K. Breddin, B.-J. Rasch, M. Camerer, R. H. Bödeker, N. Bender, W. Schneider, D. Staufenbiel, W. D. Bussmann
Publikováno v:
Verhandlungen der Deutschen Gesellschaft für Innere Medizin ISBN: 9783807003429
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf445c6a9bc1ba530cf945a7e7ca9884
https://doi.org/10.1007/978-3-642-85457-6_28
https://doi.org/10.1007/978-3-642-85457-6_28