Zobrazeno 1 - 10
of 722
pro vyhledávání: '"R, Breslow"'
Publikováno v:
Behavioral Ecology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5ace86f6d5dcdd597f3c4e27fa6a122
https://doi.org/10.1093/beheco/ary111
https://doi.org/10.1093/beheco/ary111
Autor:
Emily R. Breslow, Elizabeth B. Klerman, Jean M. Huang, Melissa A. St. Hilaire, Andrew J. K. Phillips
Publikováno v:
Journal of Biological Rhythms. 28:79-89
Melatonin is endogenously produced and released in humans during nighttime darkness and is suppressed by ocular light exposure. Exogenous melatonin is used to induce circadian phase shifts and sleep. The circadian phase-shifting ability of a stimulus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d8989b0503e7dc9e5cd0b710a9f38ad
https://doi.org/10.1177/0748730412468081
https://doi.org/10.1177/0748730412468081
Akademický článek
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Autor:
Geraldine L. Crean, R. Breslow, John J. Martin, Maryrose J. Conklyn, Cathy A. Farrell, G. Todd Miller, M. S. Biggers, Hada William Andrew, Henry J. Showell, Kevin Koch, Ellen R. Laird, John B. Cheng, Lawrence A. Reiter, Lawrence S. Melvin, Joanne S. Pillar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2307-2312
The SAR of a series of 7-chromanylacetic acids has been investigated with the aim of identifying potent and selective LTB4 receptor antagonists. We found optimal activity in derivatives with c~,c~-disubstitution on the acetic acid and a C-4 hydroxy g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95ffce05c9a2a2bfe344a170fdc4f074
https://doi.org/10.1016/s0960-894x(97)00414-9
https://doi.org/10.1016/s0960-894x(97)00414-9
Publikováno v:
British Journal of Pharmacology. 117:1127-1132
1. Binding of [3H]-leukotriene B4 ([3H]-LTB4) to murine spleen membranes (MSM) was determined. 2. Scatchard analyses of [3H]-LTB4 binding indicated the presence of high (KD1 = 1.7 nM) and low (KD2 = 7.5 nM) affinity receptors on MSM with Bmax values
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c8809520b0dfcb58b5a0a5265f25e9
https://doi.org/10.1111/j.1476-5381.1996.tb16706.x
https://doi.org/10.1111/j.1476-5381.1996.tb16706.x
Autor:
G.W. Antognoli, J.T. Shirley, A. Marfat, C.F. Wright, Thomas J. Carty, Frank W. Rusek, J. W. Watson, J. Delehunt, B. A. Naclerio, James F. Eggler, J.S. Pillar, Herbert Sherman, E.G. Andrews, Francis J. Sweeney, K. W. Freiert, R. Breslow, C. J. Mularski, V. L. Cohan, C J Pazoles, Lawrence S. Melvin, L.A. Rappach, John B. Cheng, David B. Damon, Jeanene E. Tickner, Judith L. Collins, P. Reiche, Hiroko Masamune, M. P. Carta, James D. Eskra, Hada William Andrew, R. J. Chambers
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1365-1370
The development of two novel LTD 4 receptor antagonists as clinical candidates for the treatment of asthma is described. The first generation compound, CP-80,798, was found to be a balanced 5-lipoxygenase inhibitor (5-LOI)/LTD 4 antagonist (LTD 4 -A)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a5fced5f481925dbd55bd727448996c
https://doi.org/10.1016/0960-894x(95)00225-i
https://doi.org/10.1016/0960-894x(95)00225-i
Autor:
Hiroko Masamune, J.T. Shirley, A. Marfat, John B. Cheng, Henry J. Showell, James F. Eggler, J.S. Pillar, Maryrose J. Conklyn, Jeanene E. Tickner, Lawrence S. Melvin, R. Breslow
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:887-892
The development of novel LTB 4 antagonists from a class of quinolylmethyl LTD 4 antagonists is described. These α-methyl quinolylmethyl chromanols were found to have good vitro activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08bc619e3458f6601bd9c56e28f19264
https://doi.org/10.1016/0960-894x(95)00135-g
https://doi.org/10.1016/0960-894x(95)00135-g
Autor:
Norma P. Gerard, H J Showell, Lee F. Kolakowski, M J Conklyn, Carmen R. Bozic, C von Uexkull-Guldenband, Craig Gerard, R Breslow
Publikováno v:
Journal of Biological Chemistry. 269:29355-29358
KC, the product of an immediate early gene induced in mouse fibroblasts by platelet-derived growth factor, was synthesized as a recombinant protein in Escherichia coli and binds with 0.8 nM affinity to mouse neutrophils. Human neutrophils also bind r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b827a47ab329e1c0b51019934fa3332
https://doi.org/10.1016/s0021-9258(18)43882-3
https://doi.org/10.1016/s0021-9258(18)43882-3
Autor:
R. BRESLOW
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7479c39ce098893c8ff5b97ddfb2418
https://doi.org/10.1002/chin.199446295
https://doi.org/10.1002/chin.199446295
Autor:
E. G. ANDREWS, G. W. ANTOGNOLI, R. BRESLOW, M. P. CARTA, T. J. CARTY, R. J. CHAMBERS, J. B. CHENG, V. L. COHAN, J. L. COLLINS, D. B. DAMON, J. DELEHUNT, J. F. EGGLER, J. D. ESKRA, K. W. FREIERT, W. A. HADA, A. MARFAT, H. MASAMUNE, L. S. MELVIN, C. J. MULARSKI, B. A. NACLERIO, et al. et al.
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c628a89c65d567bd8f9cac390f92e716
https://doi.org/10.1002/chin.199544142
https://doi.org/10.1002/chin.199544142