Zobrazeno 1 - 10
of 186
pro vyhledávání: '"R, Bellone"'
Autor:
Carl-Johan Rubin, McKaela Hodge, Rakan Naboulsi, Madeleine Beckman, Rebecca R. Bellone, Angelica Kallenberg, Stephanie J’Usrey, Hajime Ohmura, Kazuhiro Seki, Risako Furukawa, Aoi Ohnuma, Brian W. Davis, Teruaki Tozaki, Gabriella Lindgren, Leif Andersson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The Greying with age phenotype in horses involves loss of hair pigmentation whereas skin pigmentation is not reduced, and a predisposition to melanoma. The causal mutation was initially reported as a duplication of a 4.6 kb intronic sequence
Externí odkaz:
https://doaj.org/article/6d1e89a9321a4cff8fdffdebfd0b73fa
Autor:
Elouise K. Bacon, Callum G. Donnelly, Rebecca R. Bellone, Bianca Haase, Carrie J. Finno, Brandon D. Velie
Publikováno v:
BMC Veterinary Research, Vol 20, Iss 1, Pp 1-13 (2024)
Abstract Background The pleiotropic effects of the melanocortin system show promise in overcoming limitations associated with large variations in opioid analgesic effectiveness observed in equine practice. Of particular interest is variation in the m
Externí odkaz:
https://doaj.org/article/e314d412bdef4f8996b9f785a2cc01b7
Autor:
S. A. Durward-Akhurst, J. L. Marlowe, R. J. Schaefer, K. Springer, B. Grantham, W. K. Carey, R. R. Bellone, J. R. Mickelson, M. E. McCue
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Disease-causing variants have been identified for less than 20% of suspected equine genetic diseases. Whole genome sequencing (WGS) allows rapid identification of rare disease causal variants. However, interpreting the clinical variant conse
Externí odkaz:
https://doaj.org/article/61fc3546b2a54d05af17c390a479ce64
Autor:
Eleonora Cappelletti, Francesca M. Piras, Lorenzo Sola, Marco Santagostino, Jessica L. Petersen, Rebecca R. Bellone, Carrie J. Finno, Sichong Peng, Ted S. Kalbfleisch, Ernest Bailey, Solomon G. Nergadze, Elena Giulotto
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-8 (2023)
Abstract Centromeres are epigenetically specified by the histone H3 variant CENP-A. Although mammalian centromeres are typically associated with satellite DNA, we previously demonstrated that the centromere of horse chromosome 11 (ECA11) is completel
Externí odkaz:
https://doaj.org/article/b5274ddafb684276b98a563f2ce96a3b
Autor:
Samantha Hammack, Devon Wallis Hague, Miranda D. Vieson, Elizabeth Esdaile, Shayne S. Hughes, Rebecca R. Bellone, Annette M. McCoy
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 37, Iss 5, Pp 1710-1715 (2023)
Abstract Background Globoid cell leukodystrophy (GCL) is a fatal autosomal recessive disease caused by variants in the galactosylceramidase (GALC) gene. Two dog breed‐specific variants are reported. Objectives Characterize the putatively causative
Externí odkaz:
https://doaj.org/article/5e750c089bc3462eb10b5c2bebeedfc9
Autor:
Stephanie J. Valberg, Abigail E. Schultz, Carrie J. Finno, Rebecca R. Bellone, Shayne S. Hughes
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 36, Iss 3, Pp 1152-1159 (2022)
Abstract Background The prevalence of clinical signs and factors triggering muscle atrophy and rhabdomyolysis associated with an MYH1E321G mutation in Quarter Horses and related breeds (QH) remain poorly understood. Hypothesis/Objectives Determine th
Externí odkaz:
https://doaj.org/article/f2be8ab825a54224abc527b7ea46a4a5
Autor:
Steve Horvath, Amin Haghani, Sichong Peng, Erin N. Hales, Joseph A. Zoller, Ken Raj, Brenda Larison, Todd R. Robeck, Jessica L. Petersen, Rebecca R. Bellone, Carrie J. Finno
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Methylation levels of specific sites in the genome is correlated with aging. Here the authors develop a human-horse clock which could assist in translating anti-aging interventions from humans to horses and vice versa.
Externí odkaz:
https://doaj.org/article/b6d84436d0aa47928604d293e0954a71
Autor:
Sichong Peng, Anna R Dahlgren, Callum G Donnelly, Erin N Hales, Jessica L Petersen, Rebecca R Bellone, Ted Kalbfleisch, Carrie J Finno
Publikováno v:
PLoS Genetics, Vol 19, Iss 3, p e1010468 (2023)
The genomic sequence of the horse has been available since 2009, providing critical resources for discovering important genomic variants regarding both animal health and population structures. However, to fully understand the functional implications
Externí odkaz:
https://doaj.org/article/1876f7e0d619444dac57309eeaae8585
Autor:
E. A. Hisey, H. Hermans, Z. T. Lounsberry, F. Avila, R. A. Grahn, K. E. Knickelbein, S. A. Duward-Akhurst, M. E. McCue, T.S. Kalbfleisch, M. E. Lassaline, W. Back, R. R. Bellone
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-13 (2020)
Abstract Background Distichiasis, an ocular disorder in which aberrant cilia (eyelashes) grow from the opening of the Meibomian glands of the eyelid, has been reported in Friesian horses. These misplaced cilia can cause discomfort, chronic keratitis,
Externí odkaz:
https://doaj.org/article/4eb83d9342b4460cbc29b5200a4460fa
Autor:
Callum G. Donnelly, Rebecca R. Bellone, Erin N. Hales, Annee Nguyen, Scott A. Katzman, Ghislaine A. Dujovne, Kelly E. Knickelbein, Felipe Avila, Ted S. Kalbfleisch, Elena Giulotto, Nicole B. Kingsley, Jocelyn Tanaka, Elizabeth Esdaile, Sichong Peng, Anna Dahlgren, Anna Fuller, Michael J. Mienaltowski, Terje Raudsepp, Verena K. Affolter, Jessica L. Petersen, Carrie J. Finno
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Following the successful creation of a biobank from two adult Thoroughbred mares, this study aimed to recapitulate sample collection in two adult Thoroughbred stallions as part of the Functional Annotation of the Animal Genome (FAANG) initiative. Bot
Externí odkaz:
https://doaj.org/article/2f2719d3a3764154959062fb21199023