Zobrazeno 1 - 10
of 66
pro vyhledávání: '"R, Bazzanini"'
Autor:
Suzanne Peyrottes, Gilles Gosselin, R. Bazzanini, Stefano Manfredini, Christian Périgaud, Marie-Hélène Gouy
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 24:1635-1649
Synthetic pathways to a mononucleotide prodrug of cytarabine (Ara-C) bearing S-pivaloyl-2-thioethyl (tBuSATE) groups, as biolabile phosphate protections, are reported. Using a common phosphoramidite approach, two different kinds of nucleoside protect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b5dec7c5836e0ca161b38c7703c6bd
https://doi.org/10.1080/15257770500267006
https://doi.org/10.1080/15257770500267006
Autor:
Demontis F, Pier Giovanni Baraldi, Silvia Vertuani, L. Vargiu, Stefano Manfredini, La Colla P, Elisa Durini, Tiziana Marceddu, Alessandra Pani, R. Bazzanini
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 19:705-722
Continuing our studies on the structure-activity relationships (SAR) of 4-iodo-1-beta-D-ribofuranosyl-3-carboxymethyl pyrazole (IPCAR), the ribofuranosyl moiety has been substituted with acyclic chains, namely 1-[(2-hydroxyethoxy)methyl]- and 1-[(1,3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::057816425b942ed0569dae8fc5d87dc5
https://doi.org/10.1080/15257770008035019
https://doi.org/10.1080/15257770008035019
Autor:
M. Putzolu, Chiara Musiu, Maurizio Manfrini, G. Perra, Maria Elena Marongiu, R. Bazzanini, Chiara Beatrice Vicentini, Stefano Manfredini
Publikováno v:
Archiv der Pharmazie. 331:269-272
In view of the biological relevance of triazole-based heterocyclic structures as antifungal, antiviral, and antitumor agents, we have synthesized a series of substituted pyrazolo[3,4-d]-1,2,3-triazoles (2e-h, 2j, 4b) which we evaluated for their cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::517ba51c530b4c74e65566d439451b46
https://doi.org/10.1002/(sici)1521-4184(19989)331:9<269::aid-ardp269>3.0.co
https://doi.org/10.1002/(sici)1521-4184(19989)331:9<269::aid-ardp269>3.0.co
Autor:
Jan Balzarini, Erik De Clercq, Daniele Simoni, R. Ferroni, Sigrid Hatse, Silvia Vertuani, Stefano Manfredini, R. Bazzanini
Publikováno v:
Journal of Medicinal Chemistry. 40:3851-3857
In a dual targeting approach, to explore the ability of tretinoin (all-trans-retinoic acid) to behave as a covalent carrier for cytotoxic entities, conjugates of retinoic acid with a few representative molecules, being important examples of antitumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b295a464fbe844efb8b4d8942bd5ca4
https://doi.org/10.1021/jm9602322
https://doi.org/10.1021/jm9602322
Autor:
F. Scintu, Pier Giovanni Baraldi, Donatella Lichino, Alessandra Pani, Silvia Vertuani, Daniele Simoni, R. Bazzanini, Stefano Manfredini, Paolo La Colla, Elisabetta Pinna
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1279-1284
In a SAR study on azole-related nucleosides we have designed some pyrazole-nucleoside analogs characterised, for the first time, by a carboxylic ester moiety. 4-Iodo-1-β-D-ribofuranosyl-pyrazole-3-carboxylate showed a wide spectrum of antiproliferat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b0ef7f26ba8b20faebb68c5f60aa5a
https://doi.org/10.1016/0960-894x(96)00216-8
https://doi.org/10.1016/0960-894x(96)00216-8
Publikováno v:
Tetrahedron Letters. 35:5709-5712
Tetrahydropyranyl (THP) derivatives of alcohols are converted in one-pot and in stereoselective manner into the corresponding 1- O -alkyl-2,3,5-tri- O -benzoyl-β-D-ribofuranosides on treatment with 1- O -acetyl-2,3,5-tri- O -benzoyl-β-D-ribofuranos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe54fc0a1d0f0d418445956c0935f30f
https://doi.org/10.1016/s0040-4039(00)77285-6
https://doi.org/10.1016/s0040-4039(00)77285-6
Autor:
Daniele Simoni, Stefano Manfredini, E. De Clercq, Mario Guarneri, R. Bazzanini, Jan Balzarini, P. G. Baraldi
Publikováno v:
Journal of Medicinal Chemistry. 37:2401-2405
As a continuation of previous studies on the synthesis and antitumor activity of geiparvarin analogues bearing a carbamate moiety in the alkyl side chain, a series of N-substituted [(E)-3-(4,5-dihydro-5,5-dimethyl-4-oxo-2-furanyl)-2- butenyl]carbamat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4959ca47657eaaf125f9ec7e199f83
https://doi.org/10.1021/jm00041a019
https://doi.org/10.1021/jm00041a019
Publikováno v:
Tetrahedron Letters. 34:3177-3180
Treatment of 1-(2,3,5-tri- O -acetyl-β- d -arabinofuranosyl) -5-[2-(trimethylsilyl)-vinyl]uracil ( 3 ) with pyridinium bromide perbromide and deacetylation gave BVAraU ( 2 ). Pig liver esterase (EC 3.1.1.1) catalysed the regioselective hydrolysis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25ee20c92a3514d050d91002e9a41123
https://doi.org/10.1016/s0040-4039(00)93411-7
https://doi.org/10.1016/s0040-4039(00)93411-7
Autor:
Alessandra Pani, Pier Giovanni Baraldi, Maria Elena Marongiu, Mario Guarneri, P. La Colla, Enzo Tramontano, Stefano Manfredini, R. Bazzanini, Daniele Simoni
Publikováno v:
ChemInform. 23
Several pyrazole and pyrazolo[4,3-d]-1,2,3-triazin-4-one ribonucleosides were prepared and tested for antiviral/antitumor activities. Appropriate heterocyclic bases were prepared by standard methodologies. Glycosylation of pyrazoles 6a-e,g,i and of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9342444160ad9cc98ed2934331ba6e3e
https://doi.org/10.1002/chin.199226282
https://doi.org/10.1002/chin.199226282
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfc1b0aa64937b4b4103d2254e79ddc6
https://doi.org/10.1002/chin.199340290
https://doi.org/10.1002/chin.199340290