Zobrazeno 1 - 10
of 1 071
pro vyhledávání: '"R, Atkins"'
Autor:
Keren Papier, Joshua R. Atkins, Tammy Y. N. Tong, Kezia Gaitskell, Trishna Desai, Chibuzor F. Ogamba, Mahboubeh Parsaeian, Gillian K. Reeves, Ian G. Mills, Tim J. Key, Karl Smith-Byrne, Ruth C. Travis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The availability of protein measurements and whole exome sequence data in the UK Biobank enables investigation of potential observational and genetic protein-cancer risk associations. We investigated associations of 1463 plasma proteins with
Externí odkaz:
https://doaj.org/article/55127cf5124246838e811d932f16b540
Autor:
Trishna A. Desai, Åsa K. Hedman, Marios Dimitriou, Mine Koprulu, Sandy Figiel, Wencheng Yin, Mattias Johansson, Eleanor L. Watts, Joshua R. Atkins, Aleksandr V. Sokolov, Helgi B. Schiöth, Marc J. Gunter, Konstantinos K. Tsilidis, Richard M. Martin, Maik Pietzner, Claudia Langenberg, Ian G. Mills, Alastair D. Lamb, Anders Mälarstig, Tim J. Key, Ruth C. Travis, Karl Smith-Byrne
Publikováno v:
EBioMedicine, Vol 105, Iss , Pp 105168- (2024)
Summary: Background: Understanding the role of circulating proteins in prostate cancer risk can reveal key biological pathways and identify novel targets for cancer prevention. Methods: We investigated the association of 2002 genetically predicted ci
Externí odkaz:
https://doaj.org/article/1ace1755f8ce4d638c80b4c3f3d25968
Autor:
Dilara Yılmaz, Francisco C. Marques, Yannick Fischer, Sandra Zimmermann, Gaonhae Hwang, Penny R. Atkins, Neashan Mathavan, Amit Singh, Pedro P.C. de Souza, Gisela A. Kuhn, Esther Wehrle, Ralph Müller
Publikováno v:
Heliyon, Vol 10, Iss 12, Pp e32949- (2024)
Osteoclasts are essential for bone remodeling by adapting their resorptive activity in response to their mechanical in vivo environment. However, the molecular mechanisms underlying this process remain unclear. Here, we demonstrated the role of tartr
Externí odkaz:
https://doaj.org/article/2c19d0aea6ad4f23b8eb6ead6fd3d6a9
Autor:
Gaoyang Liang, Tae Gyu Oh, Nasun Hah, Hervé Tiriac, Yu Shi, Morgan L. Truitt, Corina E. Antal, Annette R. Atkins, Yuwenbin Li, Cory Fraser, Serina Ng, Antonio F. M. Pinto, Dylan C. Nelson, Gabriela Estepa, Senada Bashi, Ester Banayo, Yang Dai, Christopher Liddle, Ruth T. Yu, Tony Hunter, Dannielle D. Engle, Haiyong Han, Daniel D. Von Hoff, Michael Downes, Ronald M. Evans
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Oncogenic lesions in pancreatic ductal adenocarcinoma (PDAC) hijack the epigenetic machinery in stromal components to establish a desmoplastic and therapeutic resistant tumor microenvironment (TME). Here we identify Class I histone deacetyla
Externí odkaz:
https://doaj.org/article/7cb7b07e6adf42b0aac1cff0935b9ca2
Autor:
Corina E. Antal, Tae Gyu Oh, Stefan Aigner, En-Ching Luo, Brian A. Yee, Tania Campos, Hervé Tiriac, Katherine L. Rothamel, Zhang Cheng, Henry Jiao, Allen Wang, Nasun Hah, Elizabeth Lenkiewicz, Jan C. Lumibao, Morgan L. Truitt, Gabriela Estepa, Ester Banayo, Senada Bashi, Edgar Esparza, Ruben M. Munoz, Jolene K. Diedrich, Nicole M. Sodir, Jasmine R. Mueller, Cory R. Fraser, Erkut Borazanci, David Propper, Daniel D. Von Hoff, Christopher Liddle, Ruth T. Yu, Annette R. Atkins, Haiyong Han, Andrew M. Lowy, Michael T. Barrett, Dannielle D. Engle, Gerard I. Evan, Gene W. Yeo, Michael Downes, Ronald M. Evans
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy in need of new therapeutic options. Using unbiased analyses of super-enhancers (SEs) as sentinels of core genes involved in cell-specific function, here we uncover a druggable SE
Externí odkaz:
https://doaj.org/article/57cc744cc0404cd39ed1bebee4e6eee7
Autor:
Sherif Abouelhadid, Elizabeth R. Atkins, Emily J. Kay, Ian J. Passmore, Simon J. North, Burhan Lehri, Paul Hitchen, Eirik Bakke, Mohammed Rahman, Janine T. Bossé, Yanwen Li, Vanessa S. Terra, Paul R. Langford, Anne Dell, Brendan W. Wren, Jon Cuccui
Publikováno v:
Microbial Cell Factories, Vol 22, Iss 1, Pp 1-13 (2023)
Abstract Conjugate vaccines produced either by chemical or biologically conjugation have been demonstrated to be safe and efficacious in protection against several deadly bacterial diseases. However, conjugate vaccine assembly and production have sev
Externí odkaz:
https://doaj.org/article/7c268aec51534a47a4626a4fff3d99d6
Autor:
Nashid Hafiz, Karice Hyun, Qiang Tu, Andrew Knight, Charlotte Hespe, Clara K Chow, Tom Briffa, Robyn Gallagher, Christopher M Reid, David L Hare, Nicholas Zwar, Mark Woodward, Stephen Jan, Emily R Atkins, Tracey-Lea Laba, Elizabeth Halcomb, Tracey Johnson, Deborah Manandi, Tim Usherwood, Julie Redfern
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0298777 (2024)
BackgroundThis study evaluates primary care practices' engagement with various features of a quality improvement (QI) intervention for patients with coronary heart disease (CHD) in four Australian states.MethodsTwenty-seven practices participated in
Externí odkaz:
https://doaj.org/article/9fbf0f5d2cf54ff5848b04dddddd8ed2
Autor:
Caitlyn J. Collins, Penny R. Atkins, Nicholas Ohs, Michael Blauth, Kurt Lippuner, Ralph Müller
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract High resolution peripheral quantitative computed tomography (HR-pQCT) provides methods for quantifying volumetric bone mineral density and microarchitecture necessary for early diagnosis of bone disease. When combined with a longitudinal ima
Externí odkaz:
https://doaj.org/article/db0204e936ac4afd94f567bccf5894ec
Autor:
Ricardo Cortez Cardoso Penha, Karl Smith-Byrne, Joshua R Atkins, Philip C Haycock, Siddhartha Kar, Veryan Codd, Nilesh J Samani, Christopher Nelson, Maja Milojevic, Aurélie AG Gabriel, Christopher Amos, Paul Brennan, Rayjean J Hung, Linda Kachuri, James D Mckay
Publikováno v:
eLife, Vol 12 (2023)
Background: Genome-wide association studies (GWASs) have identified genetic susceptibility variants for both leukocyte telomere length (LTL) and lung cancer susceptibility. Our study aims to explore the shared genetic basis between these traits and i
Externí odkaz:
https://doaj.org/article/bd1895155d114b3c8d5246296fedde43
Autor:
Nawazish Khan, Andrew C. Peterson, Benjamin Aubert, Alan Morris, Penny R. Atkins, Amy L. Lenz, Andrew E. Anderson, Shireen Y. Elhabian
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Statistical shape modeling is an indispensable tool in the quantitative analysis of anatomies. Particle-based shape modeling (PSM) is a state-of-the-art approach that enables the learning of population-level shape representation from medical imaging
Externí odkaz:
https://doaj.org/article/2e746af56c9e4104b0f3451f2a79591d