Zobrazeno 1 - 10
of 1 642
pro vyhledávání: '"R, Aho"'
Autor:
Erin R. Aho, Jing Wang, Rocco D. Gogliotti, Gregory C. Howard, Jason Phan, Pankaj Acharya, Jonathan D. Macdonald, Ken Cheng, Shelly L. Lorey, Bin Lu, Sabine Wenzel, Audra M. Foshage, Joseph Alvarado, Feng Wang, J. Grace Shaw, Bin Zhao, April M. Weissmiller, Lance R. Thomas, Christopher R. Vakoc, Matthew D. Hall, Scott W. Hiebert, Qi Liu, Shaun R. Stauffer, Stephen W. Fesik, William P. Tansey
Publikováno v:
Cell Reports, Vol 26, Iss 11, Pp 2916-2928.e13 (2019)
Summary: The chromatin-associated protein WDR5 is a promising target for pharmacological inhibition in cancer. Drug discovery efforts center on the blockade of the “WIN site” of WDR5, a well-defined pocket that is amenable to small molecule inhib
Externí odkaz:
https://doaj.org/article/624392b24e9c465daac627e90b1195e5
Autor:
Stephen W. Fesik, Dai H. Chung, William P. Tansey, David K. Flaherty, Alissa D. Guarnaccia, Eric J. Rellinger, April M. Weissmiller, Shelly L. Lorey, Brittany K. Matlock, Erin R. Aho, Chase M Woodley, Gregory C. Howard, Qi Liu, Audra F Bryan, Jing Wang
Publikováno v:
Nucleic Acids Research
WDR5 is a highly-conserved nuclear protein that performs multiple scaffolding functions in the context of chromatin. WDR5 is also a promising target for pharmacological inhibition in cancer, with small molecule inhibitors of an arginine-binding pocke
Autor:
Jianhua Tian, Kevin B. Teuscher, Erin R. Aho, Joseph R. Alvarado, Jonathan J. Mills, Kenneth M. Meyers, Rocco D. Gogliotti, Changho Han, Jonathan D. Macdonald, Jiqing Sai, J. Grace Shaw, John L. Sensintaffar, Bin Zhao, Tyson A. Rietz, Lance R. Thomas, William G. Payne, William J. Moore, Gordon M. Stott, Jumpei Kondo, Masahiro Inoue, Robert J. Coffey, William P. Tansey, Shaun R. Stauffer, Taekyu Lee, Stephen W. Fesik
Publikováno v:
Journal of Medicinal Chemistry. 63:656-675
Akademický článek
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Autor:
Jason Phan, Olivia W. Rossanese, J.G. Shaw, Chao Han, Leiber Thomas, DeMarco V. Camper, Bin Zhao, Erin R. Aho, S.W. Fesik, Joseph Alvarado, J.A. Bauer, Feng Wang, Bethany M. Alicie, Joannes P. Yuh, Jennifer E. Howes, Jonathan David Macdonald, Sameer Nikhar, Jiqing Sai, William G. Payne, S. Chacon Simon, Alex G. Waterson, Shaun R. Stauffer, William P. Tansey
Publikováno v:
Journal of medicinal chemistry. 62(24)
The treatment of tumors driven by overexpression or amplification of MYC oncogenes remains a significant challenge in drug discovery. Here, we present a new strategy toward the inhibition of MYC via the disruption of the protein-protein interaction b
Akademický článek
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Akademický článek
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Publikováno v:
Epigenetics Insights, Vol 12 (2019)
Epigenetics Insights
Epigenetics Insights
WDR5 is a component of multiple epigenetic regulatory complexes, including the mixed lineage leukemia (MLL)/SET complexes that deposit histone H3 lysine 4 methylation. Inhibitors of an arginine-binding cavity in WDR5, known as the WDR5-interaction (W
Autor:
Georgios I. Karras, Subhajyoti De, Claudia M. Nicolae, Alexander H.S. Vlahos, Katherine N. Choe, George Lucian Moldovan, Erin R. Aho
Publikováno v:
Journal of Biological Chemistry. 289:13627-13637
All cells rely on genomic stability mechanisms to protect against DNA alterations. PCNA is a master regulator of DNA replication and S-phase-coupled repair. PCNA post-translational modifications by ubiquitination and SUMOylation dictate how cells sta
Autor:
Bin Lu, J.G. Shaw, Hall, Bin Zhao, Jason Phan, Rocco D. Gogliotti, William P. Tansey, Shaun R. Stauffer, Christopher R. Vakoc, Feng Wang, Scott W. Hiebert, Jing Wang, Erin R. Aho, Kenneth Cheng, April M. Weissmiller, Stephen W. Fesik, Qi Liu, Lance R. Thomas, Joseph Alvarado, Pankaj Acharya, Shelly L. Lorey, Gregory C. Howard, Sabine Wenzel, Audra M. Foshage, Jonathan David Macdonald
Publikováno v:
Cell Reports, Vol 26, Iss 11, Pp 2916-2928.e13 (2019)
Cell reports
Cell reports
SUMMARY The chromatin-associated protein WDR5 is a promising target for pharmacological inhibition in cancer. Drug discovery efforts center on the blockade of the “WIN site” of WDR5, a well-defined pocket that is amenable to small molecule inhibi