The organic cation transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus

Autor: Natasha M Puri, Giovanna R Romano, Ting-Yu Lin, Quynh N Mai, Roshanak Irannejad

Publikováno v: eLife, Vol 11 (2022)

Dopamine is a key catecholamine in the brain and kidney, where it is involved in a number of physiological functions such as locomotion, cognition, emotion, endocrine regulation, and renal function. As a membrane-impermeant hormone and neurotransmitt

Externí odkaz: https://doaj.org/article/596732ebca9545fa88cd4c34dcf70187

A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes

Autor: P.A. Shenoy, Michelle L. Halls, Luigi Aurelio, Tim Quach, Joshua W. Conner, Quynh N. Mai, Stephen J. Hill, Thomas P. Davis, Meritxell Canals, Christopher J.H. Porter, Nigel W. Bunnett, Arisbel B. Gondin, Cameron J. Nowell, Holly R. Yeatman, Bim Graham, Nicholas A. Veldhuis, Jeffri S. Retamal, Daniel P. Poole, Stephen J. Briddon

Publikováno v: The Journal of Biological Chemistry

G-protein-coupled receptors (GPCRs) are traditionally known for signaling at the plasma membrane, but they can also signal from endosomes after internalization to control important pathophysiological processes. In spinal neurons, sustained endosomal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b62515ab0e736f2319a04571ef82b6
https://pubmed.ncbi.nlm.nih.gov/33515548

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Autor: Phillip J. Robinson, Daniel P. Poole, Joshua W. Conner, Nicholas Barlow, Tina Marie Lieu, Martin J. Scanlon, Virginie Escriou, Quynh N. Mai, Christopher J.H. Porter, Tim Quach, Nigel W. Bunnett, Carmen Klein Herenbrink, Luigi Aurelio, Romina Nassini, Wendy L. Imlach, Bimbil Graham, Dane D. Jensen, Jamie S. Simpson, Gareth A. Hicks, Pierangelo Geppetti, Michelle L. Halls, Serena Materazzi, Adam McCluskey, Meritxell Canals, Nicholas A. Veldhuis, MacDonald J. Christie

Publikováno v: Science Translational Medicine
Science Translational Medicine, American Association for the Advancement of Science, 2017, 9 (392), ⟨10.1126/scitranslmed.aal3447⟩
Science Translational Medicine, 2017, 9 (392), ⟨10.1126/scitranslmed.aal3447⟩

International audience; Typically considered to be cell surface sensors of extracellular signals, heterotrimeric GTP-binding protein (G protein)-coupled receptors (GPCRs) control many pathophysiological processes and are the target of 30% of therapeu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204bb3320be489643c59ccf171ce5b90
http://hdl.handle.net/2158/1113095