Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Quy H. Nguyen"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Existing methods for tissue dissociation are inefficient and lead to variable outcomes and biases. Here, the authors present a microfluidic platform that combines digestion, disaggregation and filtration of tissue to allow single cell analysis and RN
Externí odkaz:
https://doaj.org/article/df431d77a95e4931b3e810d6dee41623
Autor:
Nicholas Pervolarakis, Quy H. Nguyen, Justice Williams, Yanwen Gong, Guadalupe Gutierrez, Peng Sun, Darisha Jhutty, Grace X.Y. Zheng, Corey M. Nemec, Xing Dai, Kazuhide Watanabe, Kai Kessenbrock
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108273- (2020)
Summary: The mammary epithelial cell (MEC) system is a bilayered ductal epithelium of luminal and basal cells, maintained by a lineage of stem and progenitor populations. Here, we used integrated single-cell transcriptomics and chromatin accessibilit
Externí odkaz:
https://doaj.org/article/5fabc0e8b3a54c8a8a98e76a459fb86b
Autor:
Quy H. Nguyen, Nicholas Pervolarakis, Kerrigan Blake, Dennis Ma, Ryan Tevia Davis, Nathan James, Anh T. Phung, Elizabeth Willey, Raj Kumar, Eric Jabart, Ian Driver, Jason Rock, Andrei Goga, Seema A. Khan, Devon A. Lawson, Zena Werb, Kai Kessenbrock
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Epithelial subpopulations are present in the human breast but how these differentiate or form is unclear. Here, the authors use single-cell RNA sequencing of primary human breast epithelial cells to define previously undescribed luminal, basal epithe
Externí odkaz:
https://doaj.org/article/91b73d5c18954375862a70796e2fa7c2
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
Single-cell transcriptomic technologies have emerged as powerful tools to explore cellular heterogeneity at the resolution of individual cells. Previous scientific knowledge in cell biology is largely limited to data generated by bulk profiling metho
Externí odkaz:
https://doaj.org/article/c9d92361240741358f8d721c550e903f
Autor:
Scott A. Greilach, Laura L. McIntyre, Quy H. Nguyen, Jorge Silva, Kai Kessenbrock, Thomas E. Lane, Craig M. Walsh
Publikováno v:
The Journal of Immunology. 210:1677-1686
Transplantation of human neural stem cells (hNSCs) is a promising regenerative therapy to promote remyelination in patients with multiple sclerosis (MS). Transplantation of hNSCs has been shown to increase the number of CD4+CD25+Foxp3+ T regulatory c
Autor:
Kevin Nee, Dennis Ma, Quy H. Nguyen, Maren Pein, Nicholas Pervolarakis, Jacob Insua-Rodríguez, Yanwen Gong, Grace Hernandez, Hamad Alshetaiwi, Justice Williams, Maha Rauf, Kushal Rajiv Dave, Keerti Boyapati, Aliza Hasnain, Christian Calderon, Anush Markaryan, Robert Edwards, Erin Lin, Ritesh Parajuli, Peijie Zhou, Qing Nie, Sundus Shalabi, Mark A. LaBarge, Kai Kessenbrock
Publikováno v:
Nature Genetics. 55:595-606
Autor:
Olga V. Razorenova, David A. Fruman, Luke J. Nelson, Quy H. Nguyen, Matthew W. Pavesic, Monika K. Singha, Alejandro Alvarez, Jordan M. Thompson
Supplementary Figure 1. VHL re-expression blocks HIF expression. Western blot showing the effect of VHL re-expression in CC-RCC cell lines on HIF1α, HIF2α, and LDHA (HIF target gene) expression. α- tubulin serves as a loading control. Supplementar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e2a447d0d3746eb13d0af915c27afc
https://doi.org/10.1158/1535-7163.22510381.v1
https://doi.org/10.1158/1535-7163.22510381.v1
Autor:
George Chen, Kai Kessenbrock, Da Zhao, Jie Wu, Marian L. Waterman, Stephanie J. Hachey, Shuxiong Wang, Ryan T. Davis, Tuyen Hoang, Nicholas Pervolarakis, Christopher C.W. Hughes, Elizabeth Celaya, Silva Movsesyan, Quy H. Nguyen, Samantha Gomez, Devon A. Lawson, Michaela M.S. Hatch, Abraham P. Lee, John Lowengrub, Ani Tankazyan, Giselle Burton-Sojo, Kevin Nee
Publikováno v:
Lab on a Chip
Around 95% of anti-cancer drugs that show promise during preclinical study fail to gain FDA-approval for clinical use. This failure of the preclinical pipeline highlights the need for improved, physiologically-relevant in vitro models that can better
Autor:
Yanwen Gong, Kai Kessenbrock, Quy H. Nguyen, Remy Vu, Xing Dai, Adam L. MacLean, Zixuan Cang, Suoqin Jin, Peng Sun, Daniel Haensel, Enrico Gratton, Qing Nie, Rachel Cinco, Morgan Dragan
Publikováno v:
Cell Reports, Vol 30, Iss 11, Pp 3932-3947.e6 (2020)
Cell reports
Cell reports, vol 30, iss 11
Cell reports
Cell reports, vol 30, iss 11
SUMMARY Our knowledge of transcriptional heterogeneities in epithelial stem and progenitor cell compartments is limited. Epidermal basal cells sustain cutaneous tissue maintenance and drive wound healing. Previous studies have probed basal cell heter
Autor:
Kai Kessenbrock, Dennis Ma, Justice W. Williams, Qing Nie, Quy H. Nguyen, Anush Markaryan, Robert Edwards, Kushal R. Dave, Yanwen Gong, Ritesh Parajuli, Nicholas Pervolarakis, Grace A. Hernandez, Maha Rauf, Christian Calderon, Maren Pein, Sundus Shalabi, Jacob Insua-Rodríguez, Kevin Nee, Hamad Alshetaiwi, Keerti Boyapati, Erin Lin, Mark A. LaBarge, Peijie Zhou
SummaryWomen with germline mutations in BRCA1 (BRCA1+/mut) have increased risk for developing hereditary breast cancer1, 2. Cancer initiation in BRCA1+/mut is associated with pre-malignant changes in the breast epithelium including altered differenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1dce99d86c30481daf1bafd5cbdb389
https://doi.org/10.1101/2021.10.20.465221
https://doi.org/10.1101/2021.10.20.465221