Report on the 22nd International Mammalian Genome Conference.

Autor: Quwailid, Mohamed Mohideen¹ (AUTHOR), Parsons, Michael James¹ (AUTHOR), Denny, Paul¹ (AUTHOR) p.denny@har.mrc.ac.uk

Publikováno v: Mammalian Genome. Apr2021, Vol. 32 Issue 2, p129-133. 5p.

A resource of targeted mutant mouse lines for 5,061 genes

Autor: Birling, Marie-Christine, Yoshiki, Atsushi, Chiani, Francesco, Kaloff, Cornelia, Hörlein, Andreas, Teichmann, Sandy, Tasdemir, Adriane, Krause, Heidi, German, Dorota, Könitzer, Anne, Weber, Sarah, Beig, Joachim, McKay, Matthew, Chin, Hsian-Jean Genie, Bedigian, Richard, Dion, Stephanie, Kutny, Peter, Kelmenson, Jennifer, Perry, Emily, Nguyen-Bresinsky, Dong, Seluke, Audrie, Leach, Timothy, Perkins, Sara, Slater, Amanda, Christou, Skevoulla, Petit, Michaela, Urban, Rachel, Kales, Susan, DaCosta, Michael, McFarland, Michael, Palazola, Rick, Peterson, Kevin A, Svenson, Karen, Braun, Robert E, Taft, Robert, Codner, Gemma F, Rhue, Mark, Garay, Jose, Clary, Dave, Araiza, Renee, Grimsrud, Kristin, Bower, Lynette, Anchell, Nicole L, Jager, Kayla M, Young, Diana L, Dao, Phuong T, DeMayo, Francesco J, Gardiner, Wendy, Bell, Toni, Kenyon, Janet, Stewart, Michelle E, Lynch, Denise, Loeffler, Jorik, Caulder, Adam, Hillier, Rosie, Quwailid, Mohamed M, Zaman, Rumana, Dickinson, Mary E, Santos, Luis, Obata, Yuichi, Iwama, Mizuho, Nakata, Hatsumi, Hashimoto, Tomomi, Kadota, Masayo, Masuya, Hiroshi, Tanaka, Nobuhiko, Miura, Ikuo, Yamada, Ikuko, Doe, Brendan, Furuse, Tamio, Selloum, Mohammed, Jacquot, Sylvie, Ayadi, Abdel, Ali-Hadji, Dalila, Charles, Philippe, Le Marchand, Elise, El Amri, Amal, Kujath, Christelle, Fougerolle, Jean-Victor, Donahue, Leah Rae, Mellul, Peggy, Legeay, Sandrine, Vasseur, Laurent, Moro, Anne-Isabelle, Lorentz, Romain, Schaeffer, Laurence, Dreyer, Dominique, Erbs, Valérie, Eisenmann, Benjamin, Rossi, Giovanni, Fray, Martin D, Luppi, Laurence, Mertz, Annelyse, Jeanblanc, Amélie, Grau, Evelyn, Sinclair, Caroline, Brown, Ellen, Kundi, Helen, Madich, Alla, Woods, Mike, Pearson, Laila, Gambadoro, Alessia, Mayhew, Danielle, Griggs, Nicola, Houghton, Richard, Bussell, James, Ingle, Catherine, Valentini, Sara, Gleeson, Diane, Sethi, Debarati, Bayzetinova, Tanya, Burvill, Jonathan, Adams, David J, Gao, Xiang, Habib, Bishoy, Weavers, Lauren, Maswood, Ryea, Miklejewska, Evelina, Cook, Ross, Platte, Radka, Price, Stacey, Vyas, Sapna, Collinson, Adam, Hardy, Matt, Gertsenstein, Marina, Dalvi, Priya, Iyer, Vivek, West, Tony, Thomas, Mark, Mujica, Alejandro, Sins, Elodie, Barrett, Daniel, Dobbie, Michael, Grobler, Anne, Loots, Glaudina, Gomez-Segura, Alba, Hayeshi, Rose, Scholtz, Liezl-Marie, Bester, Cor, Pheiffer, Wihan, Venter, Kobus, Bosch, Fatima, Goodwin, Leslie O, Heaney, Jason D, Hérault, Yann, de Angelis, Martin Hrabě, Jiang, Si-Tse, Justice, Monica J, Kasparek, Petr, Ayabe, Shinya, King, Ruairidh E, Kühn, Ralf, Lee, Ho, Lee, Youngik, Liu, Zhiwei, Lloyd, K C Kent, Lorenzo, Isabel, Mallon, Ann-Marie, McKerlie, Colin, Meehan, Terrence F, Beaudet, Arthur L, Fuentes, Violeta Munoz, Newman, Stuart, Nutter, Lauryl M J, Oh, Goo Taeg, Pavlovic, Guillaume, Ramirez-Solis, Ramiro, Rosen, Barry, Ryder, Edward J, Santos, Luis A, Schick, Joel, Bottomley, Joanna, Seavitt, John R, Sedlacek, Radislav, Seisenberger, Claudia, Seong, Je Kyung, Skarnes, William C, Sorg, Tania, Steel, Karen P, Tamura, Masaru, Tocchini-Valentini, Glauco P, Wang, Chi-Kuang Leo, Bradley, Allan, Wardle-Jones, Hannah, Wattenhofer-Donzé, Marie, Wells, Sara, Wiles, Michael V, Willis, Brandon J, Wood, Joshua A, Wurst, Wolfgang, Xu, Ying, Consortium, International Mouse Phenotyping, Teboul, Lydia, Brown, Steve D M, Murray, Stephen A, Gallegos, Juan J, Green, Jennie R, Bohat, Ritu, Zimmel, Katie, Pereira, Monica, MacMaster, Suzanne, Tondat, Sandra, Wei, Linda, Carroll, Tracy, Bürger, Antje, Cabezas, Jorge, Fan-Lan, Qing, Jacob, Elsa, Creighton, Amie, Castellanos-Penton, Patricia, Danisment, Ozge, Clarke, Shannon, Joeng, Joanna, Kelly, Deborah, To, Christine, Bushell, Wendy, van Bruggen, Rebekah, Gailus-Durner, Valerie, Fuchs, Helmut, Marschall, Susan, Dunst, Stefanie, Romberger, Markus, Rey, Bernhard, Fessele, Sabine, Gormanns, Philipp, Friedel, Roland

Publikováno v: Nature Genetics
Nature Genetics, Nature Publishing Group, 2021, ⟨10.1038/s41588-021-00825-y⟩
Nature genetics, vol 53, iss 4
Nature genetics 53(4), 416-419 (2021). doi:10.1038/s41588-021-00825-y
Nature genetics (Online) 53 (2021): 416–419. doi:10.1038/s41588-021-00825-y
info:cnr-pdr/source/autori:Birling MC, Yoshiki A, Adams DJ, Ayabe S, Beaudet AL, Bottomley J, Bradley A, Brown SDM, Bürger A, Bushell W, Chiani F, Chin HG, Christou S, Codner GF, DeMayo FJ, Dickinson ME, Doe B, Donahue LR, Fray MD, Gambadoro A, Gao X, Gertsenstein M, Gomez-Segura A, Goodwin LO, Heaney JD, Hérault Y, de Angelis MH, Jiang ST, Justice MJ, Kasparek P, King RE, Kühn R, Lee H, Lee YJ, Liu Z, Lloyd KCK, Lorenzo I, Mallon AM, McKerlie C, Meehan TF, Fuentes VM, Newman S, Nutter LMJ, Oh GT, Pavlovic G, Ramirez-Solis R, Rosen B, Ryder EJ, Santos LA, Schick J, Seavitt JR, Sedlacek R, Seisenberger C, Seong JK, Skarnes WC, Sorg T, Steel KP, Tamura M, Tocchini-Valentini GP, Wang CL, Wardle-Jones H, Wattenhofer-Donzé M, Wells S, Wiles MV, Willis BJ, Wood JA, Wurst W, Xu Y; International Mouse Phenotyping Consortium (IMPC), Teboul L, Murray SA./titolo:A resource of targeted mutant mouse lines for 5,061 genes/doi:10.1038%2Fs41588-021-00825-y/rivista:Nature genetics (Online)/anno:2021/pagina_da:416/pagina_a:419/intervallo_pagine:416–419/volume:53
Nat. Genet. 53, 416-419 (2021)
Nat Genet

The International Mouse Phenotyping Consortium reports the generation of new mouse mutant strains for over 5,000 genes from targeted embryonic stem cells on the C57BL/6N genetic background. This includes 2,850 null alleles for which no equivalent mut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a328a0f6c9b44a9da9baebf9bee6ffa8
https://hal.archives-ouvertes.fr/hal-03065452

Insulin secretion from beta cells is affected by deletion of Nicotinamide Nucleotide Transhydrogenase

Autor: Shimomura, Kenju, Galvanovskis, Juris, Goldsworthy, Michelle, Hugill, Alison, Kaizak, Stephan, Lee, Angela, Meadows, Nicholas, Quwailid, Mohamed Mohideen, Rydström, Jan, Teboul, Lydia, Ashcroft, Fran, Cox, Roger D.

Nicotinamide nucleotide transhydrogenase (NNT) is an inner mitochondrial membrane transmembrane protein involved in regenerating NADPH, coupled with proton translocation across the inner membrane. We have shown that a defect in Nnt function in the mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::638f2a1388871cfef1e8a41c9d2e4e03
https://europepmc.org/articles/PMC5890886/

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Antisense Activity across the Nesp Promoter is Required for Nespas -Mediated Silencing in the Imprinted Gnas Cluster.

Autor: Tibbit CJ; MRC Harwell, Mammalian Genetics Unit, Harwell Campus, Oxfordshire OX110RD, UK. m.quwailid@har.mrc.ac.uk.; Current address: MRC Functional Genomics Unit, Department of Physiology Anatomy & Genetics, Le Gros Clark Building, University of Oxford, South Parks Road, Oxford OX13QX, UK. m.quwailid@har.mrc.ac.uk., Williamson CM; MRC Harwell, Mammalian Genetics Unit, Harwell Campus, Oxfordshire OX110RD, UK. charlotte.tibbit@dpag.ox.ac.uk.; Current Address: MRC Harwell, Harwell Campus, Oxfordshire OX110RD, UK. charlotte.tibbit@dpag.ox.ac.uk., Mehta S; MRC Harwell, Mammalian Genetics Unit, Harwell Campus, Oxfordshire OX110RD, UK. c.williamson@har.mrc.ac.uk.; Current address: GI Division, Their 340, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. c.williamson@har.mrc.ac.uk., Ball ST; MRC Harwell, Mammalian Genetics Unit, Harwell Campus, Oxfordshire OX110RD, UK. stuti.mehta@wolfson.oxon.org.; Current address: Mary Lyon Centre, MRC Harwell, Harwell Campus, Oxfordshire OX110RD, UK. stuti.mehta@wolfson.oxon.org., Chotalia M; Epigenetics Programme, The Babraham Institute, Cambridge CB223AT, UK. gavin.kelsey@babraham.ac.uk.; Current address: Genome Function Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, London W120NN, UK. gavin.kelsey@babraham.ac.uk., Nottingham WT; MRC Harwell, Mammalian Genetics Unit, Harwell Campus, Oxfordshire OX110RD, UK. s.ball@har.mrc.ac.uk.; Current address: West London Free School, 2 Bridge Avenue, Hammersmith, London W69JP, UK. s.ball@har.mrc.ac.uk., Eaton SA; MRC Harwell, Mammalian Genetics Unit, Harwell Campus, Oxfordshire OX110RD, UK. wadenottingham@google.com.; Current address: Molecular, Structural and Computational Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia. wadenottingham@google.com., Quwailid MM; MRC Harwell, Mammalian Genetics Unit, Harwell Campus, Oxfordshire OX110RD, UK. S.Eaton@victorchang.edu.au., Teboul L; Mary Lyon Centre, MRC Harwell, Harwell Campus, Oxfordshire OX110RD, UK. l.teboul@har.mrc.ac.uk., Kelsey G; Epigenetics Programme, The Babraham Institute, Cambridge CB223AT, UK. mita.chotalia@googlemail.com.; Centre for Trophoblast Research, University of Cambridge, Cambridge CB23EG, UK. mita.chotalia@googlemail.com., Peters J; MRC Harwell, Mammalian Genetics Unit, Harwell Campus, Oxfordshire OX110RD, UK. j.peters@har.mrc.ac.uk.

Publikováno v: Non-coding RNA [Noncoding RNA] 2015 Nov 30; Vol. 1 (3), pp. 246-265. Date of Electronic Publication: 2015 Nov 30.