Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Qurratulain Yousuf"'
Autor:
Yuanqing Ma, Allison Joyce, Olivia Brandenburg, Faeze Saatchi, Christina Stevens, Vanina Toffessi Tcheuyap, Alana Christie, Quyen N. Do, Oluwatomilade Fatunde, Alyssa Macchiaroli, So C. Wong, Layton Woolford, Qurratulain Yousuf, Jeffrey Miyata, Deyssy Carrillo, Oreoluwa Onabolu, Tiffani McKenzie, Akhilesh Mishra, Tanner Hardy, Wei He, Daniel Li, Alexander Ivanishev, Qing Zhang, Ivan Pedrosa, Payal Kapur, Thomas Schluep, Steven B. Kanner, James Hamilton, James Brugarolas
Publikováno v:
Clin Cancer Res
Purpose: HIF2α is a key driver of kidney cancer. Using a belzutifan analogue (PT2399), we previously showed in tumorgrafts (TG) that ∼50% of clear cell renal cell carcinomas (ccRCC) are HIF2α dependent. However, prolonged treatment induced resist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8031fa5b1e24fe2316880d269ddff5d7
https://doi.org/10.1158/1078-0432.ccr-22-0963
https://doi.org/10.1158/1078-0432.ccr-22-0963
Autor:
James Brugarolas, Somasekar Seshagiri, Steffen Durinck, Zora Modrusan, Eric Stawiski, Jingxuan He, Wenbin Guo, Xin Luo, Jose Torrealba, Alexander Filatenkov, Mingyi Chen, Zhiqun Xie, Christina Stevens, Oreoluwa Onabolu, Danni Luo, Xinlei Wang, Min S. Kim, Allison Joyce, Tiffani McKenzie, Yi-Feng Gu, Qurratulain Yousuf, Leonard D. Goldstein, He Zhang, Jason J. Luke, Ivan Pedrosa, Ze Zhang, Raquibul Hannan, Bijay S. Jaiswal, Payal Kapur, Rong Lu, Tao Wang
List of UTSW KCP patients with RNA-Seq and exome-seq. Sheet 1 contains information of 35 patients whose matched trio RNA-Seq data were used in the primary DisHet analyses. Sheet 2 contains information of patients whose bulk tumors were analyzed by RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44154a4e8fdbd6f699a8e21dfeb4be94
https://doi.org/10.1158/2159-8290.22532821
https://doi.org/10.1158/2159-8290.22532821
Autor:
James Brugarolas, Somasekar Seshagiri, Steffen Durinck, Zora Modrusan, Eric Stawiski, Jingxuan He, Wenbin Guo, Xin Luo, Jose Torrealba, Alexander Filatenkov, Mingyi Chen, Zhiqun Xie, Christina Stevens, Oreoluwa Onabolu, Danni Luo, Xinlei Wang, Min S. Kim, Allison Joyce, Tiffani McKenzie, Yi-Feng Gu, Qurratulain Yousuf, Leonard D. Goldstein, He Zhang, Jason J. Luke, Ivan Pedrosa, Ze Zhang, Raquibul Hannan, Bijay S. Jaiswal, Payal Kapur, Rong Lu, Tao Wang
The full technical details of DisHet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2e0a2d9909382bbf1aa83d172164ad
https://doi.org/10.1158/2159-8290.22532824.v1
https://doi.org/10.1158/2159-8290.22532824.v1
Autor:
James Brugarolas, Somasekar Seshagiri, Steffen Durinck, Zora Modrusan, Eric Stawiski, Jingxuan He, Wenbin Guo, Xin Luo, Jose Torrealba, Alexander Filatenkov, Mingyi Chen, Zhiqun Xie, Christina Stevens, Oreoluwa Onabolu, Danni Luo, Xinlei Wang, Min S. Kim, Allison Joyce, Tiffani McKenzie, Yi-Feng Gu, Qurratulain Yousuf, Leonard D. Goldstein, He Zhang, Jason J. Luke, Ivan Pedrosa, Ze Zhang, Raquibul Hannan, Bijay S. Jaiswal, Payal Kapur, Rong Lu, Tao Wang
Annotation of eTME genes. eTME genes (3x) are shown in the table. The "eTME (20x)" column shows eTME genes that satisfy the 20x cutoff. The other columns show the interpretation of the eTME genes using BLUEPRINT data, the Winslow signatures, Immunome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e08bbc4dd24e270961bf8a10e4d34e
https://doi.org/10.1158/2159-8290.22532818.v1
https://doi.org/10.1158/2159-8290.22532818.v1
Autor:
James Brugarolas, Somasekar Seshagiri, Steffen Durinck, Zora Modrusan, Eric Stawiski, Jingxuan He, Wenbin Guo, Xin Luo, Jose Torrealba, Alexander Filatenkov, Mingyi Chen, Zhiqun Xie, Christina Stevens, Oreoluwa Onabolu, Danni Luo, Xinlei Wang, Min S. Kim, Allison Joyce, Tiffani McKenzie, Yi-Feng Gu, Qurratulain Yousuf, Leonard D. Goldstein, He Zhang, Jason J. Luke, Ivan Pedrosa, Ze Zhang, Raquibul Hannan, Bijay S. Jaiswal, Payal Kapur, Rong Lu, Tao Wang
By leveraging tumorgraft (patient-derived xenograft) RNA-sequencing data, we developed an empirical approach, DisHet, to dissect the tumor microenvironment (eTME). We found that 65% of previously defined immune signature genes are not abundantly expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010b18ebe78bf41d90220e8e435388a2
https://doi.org/10.1158/2159-8290.c.6546844
https://doi.org/10.1158/2159-8290.c.6546844
Autor:
James Brugarolas, Somasekar Seshagiri, Steffen Durinck, Zora Modrusan, Eric Stawiski, Jingxuan He, Wenbin Guo, Xin Luo, Jose Torrealba, Alexander Filatenkov, Mingyi Chen, Zhiqun Xie, Christina Stevens, Oreoluwa Onabolu, Danni Luo, Xinlei Wang, Min S. Kim, Allison Joyce, Tiffani McKenzie, Yi-Feng Gu, Qurratulain Yousuf, Leonard D. Goldstein, He Zhang, Jason J. Luke, Ivan Pedrosa, Ze Zhang, Raquibul Hannan, Bijay S. Jaiswal, Payal Kapur, Rong Lu, Tao Wang
Gene ontology analysis shows enriched GO terms of the 904 eTME genes (20x cutoff) (first sheet), the 778 and the 610 eTME genes (20x cutoff) that are not captured by the Immunome alone and Immunome+ESTIMATE+Winslow gene signatures (second and third s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa48808ba34476d63c1a55fc31d147e
https://doi.org/10.1158/2159-8290.22532815
https://doi.org/10.1158/2159-8290.22532815
Autor:
James Brugarolas, Somasekar Seshagiri, Steffen Durinck, Zora Modrusan, Eric Stawiski, Jingxuan He, Wenbin Guo, Xin Luo, Jose Torrealba, Alexander Filatenkov, Mingyi Chen, Zhiqun Xie, Christina Stevens, Oreoluwa Onabolu, Danni Luo, Xinlei Wang, Min S. Kim, Allison Joyce, Tiffani McKenzie, Yi-Feng Gu, Qurratulain Yousuf, Leonard D. Goldstein, He Zhang, Jason J. Luke, Ivan Pedrosa, Ze Zhang, Raquibul Hannan, Bijay S. Jaiswal, Payal Kapur, Rong Lu, Tao Wang
Sup. Fig. 1 Simulation analyses show accurate dissection of bulk tumor RNA-Seq data by DisHet. Sup. Fig. 2 Validating immune/stroma component expression dissected by DisHet. Sup. Fig. 3 Comparison of dissection performance of DeMix and DisHet. Sup. F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ea04cd25ae475dcb47212aa2a0afc1
https://doi.org/10.1158/2159-8290.22532827.v1
https://doi.org/10.1158/2159-8290.22532827.v1
Autor:
James Brugarolas, James Hamilton, Steven B. Kanner, Thomas Schluep, Payal Kapur, Ivan Pedrosa, Qing Zhang, Alexander Ivanishev, Daniel Li, Wei He, Tanner Hardy, Akhilesh Mishra, Tiffani McKenzie, Oreoluwa Onabolu, Deyssy Carrillo, Jeffrey Miyata, Qurratulain Yousuf, Layton Woolford, So C. Wong, Alyssa Macchiaroli, Oluwatomilade Fatunde, Quyen N. Do, Alana Christie, Vanina Toffessi Tcheuyap, Christina Stevens, Faeze Saatchi, Olivia Brandenburg, Allison Joyce, Yuanqing Ma
Supp data legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6fd391ca71a3181f8dc7772c3d0499
https://doi.org/10.1158/1078-0432.22489509.v1
https://doi.org/10.1158/1078-0432.22489509.v1
Autor:
James Brugarolas, James Hamilton, Steven B. Kanner, Thomas Schluep, Payal Kapur, Ivan Pedrosa, Qing Zhang, Alexander Ivanishev, Daniel Li, Wei He, Tanner Hardy, Akhilesh Mishra, Tiffani McKenzie, Oreoluwa Onabolu, Deyssy Carrillo, Jeffrey Miyata, Qurratulain Yousuf, Layton Woolford, So C. Wong, Alyssa Macchiaroli, Oluwatomilade Fatunde, Quyen N. Do, Alana Christie, Vanina Toffessi Tcheuyap, Christina Stevens, Faeze Saatchi, Olivia Brandenburg, Allison Joyce, Yuanqing Ma
Figure S3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1cf32a796917f05cd33d2822aee108
https://doi.org/10.1158/1078-0432.22489527.v1
https://doi.org/10.1158/1078-0432.22489527.v1
Autor:
James Brugarolas, James Hamilton, Steven B. Kanner, Thomas Schluep, Payal Kapur, Ivan Pedrosa, Qing Zhang, Alexander Ivanishev, Daniel Li, Wei He, Tanner Hardy, Akhilesh Mishra, Tiffani McKenzie, Oreoluwa Onabolu, Deyssy Carrillo, Jeffrey Miyata, Qurratulain Yousuf, Layton Woolford, So C. Wong, Alyssa Macchiaroli, Oluwatomilade Fatunde, Quyen N. Do, Alana Christie, Vanina Toffessi Tcheuyap, Christina Stevens, Faeze Saatchi, Olivia Brandenburg, Allison Joyce, Yuanqing Ma
Figure S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41db127b21f63e0630e2dbf36011ffae
https://doi.org/10.1158/1078-0432.22489515
https://doi.org/10.1158/1078-0432.22489515