ATR inhibition radiosensitizes cells through augmented DNA damage and G2 cell cycle arrest abrogation.

Autor: Bright SJ; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Manandhar M; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Flint DB; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Kolachina R; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.; Department of Biosciences, Rice University, Houston, Texas, USA., Ben Kacem M; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Martinus DK; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Turner BX; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Qureshi I; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.; Emory University School of Medicine, Emory University, Atlanta, Georgia, USA., McFadden CH; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Marinello PC; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Shaitelman SF; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Sawakuchi GO; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Publikováno v: JCI insight [JCI Insight] 2024 Oct 08; Vol. 9 (19). Date of Electronic Publication: 2024 Oct 08.