Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Quoc Wu"'
Autor:
Julia Morizzi, Daniella Vullo, Quoc Wu, Michael Lloyd Williams, Claudiu T. Supuran, Adam John Salmon, Susan A. Charman, Sally-Ann Poulsen, Daniel John Gregg
Publikováno v:
Journal of Medicinal Chemistry; Vol 55
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry
In this study, 20 metallocene-based compounds comprising extensive structural diversity were synthesized and evaluated as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. These compounds proved moderate to good CA inhibitors in vitro, with several com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f7080f92489d9e6a759465f4bb9cda4
Autor:
Diego Gonzàlez Cabrera, Frederic Douelle, David Waterson, Jeremy N. Burrows, Yassir Younis, Quoc Wu, Susan A. Charman, Michael J Witty, Karen L. White, Tzu-Shean Feng, Kelly Chibale, Sergio Wittlin, Aloysius T. Nchinda, Eileen Ryan
Publikováno v:
Journal of Medicinal Chemistry. 54:7713-7719
An aminomethylthiazole pyrazole carboxamide lead 3 with good in vitro antiplasmodial activity [IC(50): 0.08 μM (K1, chloroquine and multidrug resistant strain) and 0.07 μM (NF54, chloroquine sensitive strain)] and microsomal metabolic stability was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076ed0b6da9bee5522e8d48ab42b6da3
https://doi.org/10.1021/jm201108k
https://doi.org/10.1021/jm201108k
Publikováno v:
Hepatobiliary & Pancreatic Diseases International. 10:502-508
Background Enzymes involved in drug and xenobiotic metabolism have been considered to exist in two groups: phase I and phase II enzymes. Cytochrome P450 isoenzymes (CYPs) are the most important phase I enzymes in the metabolism of xenobiotics. The pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce82af6acc14c7194455bef667ebba9
https://doi.org/10.1016/s1499-3872(11)60085-4
https://doi.org/10.1016/s1499-3872(11)60085-4
Autor:
Daniela Vullo, Susan A. Charman, Alessio Innocenti, Blessy Abraham Paul, Sally-Ann Poulsen, Andreas Hofmann, Marie Lopez, Quoc Wu, Claudiu T. Supuran, Julia Morizzi
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2009, 52 (20), pp.6421-6432. ⟨10.1021/jm900914e⟩
Journal of Medicinal Chemistry, American Chemical Society, 2009, 52 (20), pp.6421-6432. ⟨10.1021/jm900914e⟩
In this paper, we present a new class of carbonic anhydrase (CA) inhibitor that was designed to selectively target the extracellular domains of the cancer-relevant CA isozymes. The aromatic moiety of the classical zinc binding sulfonamide CA inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::981ccc3fd430b14a08d5c5d6247f2766
https://doi.org/10.1021/jm900914e
https://doi.org/10.1021/jm900914e
Publikováno v:
Food and Chemical Toxicology. 46:2118-2123
Deoxynivalenol (DON) contamination of cereal crops occurs frequently, and may cause acute exposure at high levels or chronic more moderate exposure. DON has proven toxicity including restriction of enterocyte differentiation, which may play a part in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7e43f3588c12b55fb6ea952e5bfab6
https://doi.org/10.1016/j.fct.2008.02.004
https://doi.org/10.1016/j.fct.2008.02.004
Publikováno v:
Applied and Environmental Microbiology. 73:3958-3964
The probiotic Lactobacillus rhamnosus GG is able to bind the potent hepatocarcinogen aflatoxin B 1 (AFB 1 ) and thus potentially restrict its rapid absorption from the intestine. In this study we investigated the potential of GG to reduce AFB 1 avail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3984a57258328e381b3cdee530fe752
https://doi.org/10.1128/aem.02944-06
https://doi.org/10.1128/aem.02944-06
Publikováno v:
Journal of agricultural and food chemistry. 55(4)
Previous studies have shown that anthocyanin-rich berry extracts inhibit the growth of cancer cells in vitro. The objective of this study was to compare the effects of berry extracts containing different phenolic profiles on cell viability and expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d83cdd4bc87b5cd7d7369a172ad242a
https://pubmed.ncbi.nlm.nih.gov/17243699
https://pubmed.ncbi.nlm.nih.gov/17243699