Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Qun-Tao Yu"'
Autor:
Hong Yang, Feng Xiong, Hai-Bin Qin, Qun-Tao Yu, Jin-Yan Sun, Hai-Wen Zhao, Dong Li, Youtong Zhou, Fu-Kun Zhang, Xiao-Wen Zhu, Tong Wu, Man Jiang, Xiangmin Xu, Youming Lu, Hong-Jie Shen, Wen-Bo Zeng, Fei Zhao, Min-Hua Luo
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-19 (2022)
Abstract Background Viral tracers are important tools for mapping brain connectomes. The feature of predominant anterograde transneuronal transmission offers herpes simplex virus-1 (HSV-1) strain H129 (HSV1-H129) as a promising candidate to be develo
Externí odkaz:
https://doaj.org/article/39a6c8c34adc43f0b1a50b7fb90740dd
Autor:
Ramon Brugada, Francesco J. DeMayo, Do Sun Lim, Ali J. Marian, Robert Roberts, Yun Wu, Keith A. Youker, Miguel A. Quinones, Qun Tao Yu, Meghan McCluggage
Publikováno v:
Journal of Clinical Investigation. 104:1683-1692
Certain mutations in genes for sarcomeric proteins cause hypertrophic cardiomyopathy (HCM). We have developed a transgenic rabbit model for HCM caused by a common point mutation in the beta-myosin heavy chain (MyHC) gene, R400Q. Wild-type and mutant
Publikováno v:
Proceedings of the Association of American Physicians. 111:45-56
Cardiac myocyte disarray is the pathological hallmark of hypertrophic cardiomyopathy (HCM), a disease of sarcomeric proteins. Mutations in the cardiac troponin T (cTnT), a major gene responsible for HCM, are associated with severe myocyte disarray. T
Autor:
Michael J. Sole, Robert Roberts, Marcel E. Lechin, Douglas Wigle, Rita Hill, Qun Tao Yu, Harry Rakowski, Ahmad S. Omran, Ali J. Marian, C. C. Liew, Miguel A. Quinones
Publikováno v:
Circulation. 92:1808-1812
Background The variability of the phenotypic expression of left ventricular hypertrophy (LVH) in patients with hypertrophic cardiomyopathy (HCM) indicates a potential role for additional modifying genes. Variants of angiotensin-I converting enzyme (A
Publikováno v:
Circulation Research. 77:98-106
Abstract Mutations in the β-myosin heavy chain (βMyHC) induce hypertrophic cardiomyopathy (HCM), cardiac hypertrophy, and sarcomere disarray, with the latter being the characteristic hallmark. Thus, we sought to determine whether expression of muta
Publikováno v:
Journal of Clinical Investigation. 90:2156-2165
Familial hypertrophic cardiomyopathy (FHCM) is an autosomal dominant disease affecting primarily the myocardium. The gene responsible for FHCM has been localized to chromosome 14 in some families and several mutations have been described in the beta-
Autor:
Rita Hill, Grazyna Czernuszewicz, Ali J. Marian, Robert Roberts, M B Perryman, Jonah Ifegwu, Qun-Tao Yu, Adolph Mares
Publikováno v:
Journal of Clinical Investigation. 90:271-277
We have determined that a missense mutation in exon 13 of the beta-myosin heavy chain (beta MHC) gene is expressed in the messenger RNA (mRNA) isolated from a right ventricular endomyocardial biopsy obtained from the proband of a family with hypertro
Autor:
Jonah Ifegwu, Miguel A. Quinones, Robert Roberts, Qun Tao Yu, Ramon Brugada, Terry Tapscott, Jane M. Gregoritch, Antoine Abchee, S.P. Daiger, Jeffrey L. Anderson, Linda L. Bachinski, Jeffrey A. Towbin, Jean-Bernard Durand, Grazyna Czernuszewicz, Lisa C. Bieling, Rita Hill, Ali J. Marian
Publikováno v:
Circulation. 92:3387-3389
Background Dilated cardiomyopathy, characterized by ventricular dilatation and decreased systolic contraction, is twofold to threefold more common as a cause of heart failure than hypertrophic cardiomyopathy and costs several billion dollars annually
Publikováno v:
Circulation research. 81(1)
Abstract The mechanism(s) by which mutations in sarcomeric proteins cause hypertrophic cardiomyopathy (HCM) remains unknown. A leading hypothesis proposes that mutant sarcomeric proteins impair cardiac myocyte contractility, providing an impetus for
Publikováno v:
Journal of the American College of Cardiology. 27(2)