Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Qun-Sheng JI"'
Autor:
Jonathan A. Pachter, Neil W. Gibson, Lee D. Arnold, Alexandra Eyzaguirre, Elizabeth Buck, Caroline Pirritt, Yan Yao, Matthew O'Connor, Gilda Mak, Lixin Feng, Andrew Cooke, Maryland Rosenfeld-Franklin, Mark J. Mulvihill, Qun-sheng Ji
Insulin-like growth factor-I receptor (IGF-IR) and its ligands, IGF-I and IGF-II, are up-regulated in a variety of human cancers. In tumors, such as colorectal, non–small cell lung, ovarian, and pediatric cancers, which may drive their own growth a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c6d78e18d5213a54ae84ba8a5326f5
https://doi.org/10.1158/1535-7163.c.6532205.v1
https://doi.org/10.1158/1535-7163.c.6532205.v1
Autor:
Jonathan A. Pachter, Neil W. Gibson, Lee D. Arnold, Alexandra Eyzaguirre, Elizabeth Buck, Caroline Pirritt, Yan Yao, Matthew O'Connor, Gilda Mak, Lixin Feng, Andrew Cooke, Maryland Rosenfeld-Franklin, Mark J. Mulvihill, Qun-sheng Ji
Supplementary Material from A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor–dependent tumor gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051a776eb2077a5803345e192cea0829
https://doi.org/10.1158/1535-7163.22486034.v1
https://doi.org/10.1158/1535-7163.22486034.v1
Autor:
Qun-Sheng Ji, Neil W. Gibson, John D. Haley, Kenneth K. Iwata, David Epstein, Mark Miglarese, Jonathan Pachter, Yan Yao, Mathew O'Connor, Eric Brown, Sharon Barr, Mark Mulvihill, Stuart Thomson, Maryland Rosenfeld-Franklin, Alexandra Eyzaguirre, Elizabeth Buck
Supplementary Figures 1-6 from Feedback Mechanisms Promote Cooperativity for Small Molecule Inhibitors of Epidermal and Insulin-Like Growth Factor Receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7ec92813ce2f78c103c78d45e441de
https://doi.org/10.1158/0008-5472.22373438.v1
https://doi.org/10.1158/0008-5472.22373438.v1
Autor:
Qun-Sheng Ji, Neil W. Gibson, John D. Haley, Kenneth K. Iwata, David Epstein, Mark Miglarese, Jonathan Pachter, Yan Yao, Mathew O'Connor, Eric Brown, Sharon Barr, Mark Mulvihill, Stuart Thomson, Maryland Rosenfeld-Franklin, Alexandra Eyzaguirre, Elizabeth Buck
Supplementary Table 1 from Feedback Mechanisms Promote Cooperativity for Small Molecule Inhibitors of Epidermal and Insulin-Like Growth Factor Receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3ecdb7f42194c8fd4475413f56effa
https://doi.org/10.1158/0008-5472.22373432.v1
https://doi.org/10.1158/0008-5472.22373432.v1
Autor:
Qun-Sheng Ji, Neil W. Gibson, John D. Haley, Kenneth K. Iwata, David Epstein, Mark Miglarese, Jonathan Pachter, Yan Yao, Mathew O'Connor, Eric Brown, Sharon Barr, Mark Mulvihill, Stuart Thomson, Maryland Rosenfeld-Franklin, Alexandra Eyzaguirre, Elizabeth Buck
Supplementary Methods from Feedback Mechanisms Promote Cooperativity for Small Molecule Inhibitors of Epidermal and Insulin-Like Growth Factor Receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9b5436c6114fe395eb6c96eaf2aced
https://doi.org/10.1158/0008-5472.22373435.v1
https://doi.org/10.1158/0008-5472.22373435.v1
Autor:
Qun-Sheng Ji, Neil W. Gibson, John D. Haley, Kenneth K. Iwata, David Epstein, Mark Miglarese, Jonathan Pachter, Yan Yao, Mathew O'Connor, Eric Brown, Sharon Barr, Mark Mulvihill, Stuart Thomson, Maryland Rosenfeld-Franklin, Alexandra Eyzaguirre, Elizabeth Buck
Supplementary Figure Legends from Feedback Mechanisms Promote Cooperativity for Small Molecule Inhibitors of Epidermal and Insulin-Like Growth Factor Receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f6fa5f41b4f962721e810c3623ae1c
https://doi.org/10.1158/0008-5472.22373441
https://doi.org/10.1158/0008-5472.22373441
Autor:
Andrew P. Crew, Meizhong Jin, Kristen Michelle Mulvihill, Mark J. Mulvihill, David Epstein, Qun-Sheng Ji, Shripad V. Bhagwat, Mridula Kadalbajoo, Andrew Cooke, Josef A. Rechka, Jonathan A. Pachter, Mark Bittner, Kam W. Siu, Yan Yao, Jing Wang, April Thelemann, Andrew Kleinberg
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:979-984
This Letter describes the medicinal chemistry effort towards a series of novel imidazo[1,5-a]pyrazine derived inhibitors of ACK1. Virtual screening led to the discovery of the initial hit, and subsequent exploration of structure-activity relationship
Autor:
Mark J. Mulvihill, Kenneth K. Iwata, Stuart Thomson, Yan Yao, Qun-Sheng Ji, Sharon Barr, Elizabeth Buck, David Epstein, John D. Haley, Jonathan A. Pachter, Alexandra Eyzaguirre, Eric J. Brown, Mathew O'Connor, Maryland Rosenfeld-Franklin, Mark Miglarese, Neil W. Gibson
Publikováno v:
Cancer Research. 68:8322-8332
Epidermal growth factor receptor (EGFR) and insulin-like growth factor-I receptor (IGF-IR) can cooperate to regulate tumor growth and survival, and synergistic growth inhibition has been reported for combined blockade of EGFR and IGF-IR. However, in
Autor:
W. Todd Miller, Wanqing Li, Kenneth Foreman, Jinhua Wu, Barbara P. Craddock, Mark J. Mulvihill, Qun-Sheng Ji, Stevan R. Hubbard
Publikováno v:
The EMBO Journal. 27:1985-1994
The insulin-like growth factor-1 receptor (IGF1R) is a receptor tyrosine kinase (RTK) that has a critical role in mitogenic signalling during embryogenesis and an antiapoptotic role in the survival and progression of many human tumours. Here, we pres
Autor:
Xiao-Chun BAI, Fan DENG, An-Ling LIU, Zhi-Peng ZOU, Yu WANG, Zhi-Yong KE, Qun-Sheng JI, Shen-Qiu LUO
Publikováno v:
Biochemical Journal. 363:395-401
Phospholipase C-γ1 (PLC-γ1) activation has been reported to enhance cell survival during the cellular response to oxidative stress. We studied the role of protein kinase C (PKC) pathways in mediating PLC-γ1 survival signalling in oxidative stress