Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Qun Qin"'
Autor:
Daizhuang Peng, Sumei Xu, Ting Zou, Yahui Wang, Wenjuan Ouyang, Yalan Zhang, Chengmei Dong, Dai Li, Jie Guo, Qiuying Shen, Xiaolei Hu, Wenzhi Zhou, Xiaomin Li, Qun Qin
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-11 (2023)
Abstract Background AD16 is a Class 1.1 new drug candidate for Alzheimer’s disease (AD), which has demonstrated potential benefits in AD by reducing neuroinflammation in preclinical studies. Herein, the pharmacokinetics (PK), safety, and tolerabili
Externí odkaz:
https://doaj.org/article/358e8135b8854330bee03778f3c368aa
Publikováno v:
European Journal of Medical Research, Vol 28, Iss 1, Pp 1-13 (2023)
Abstract Patients treated with hemodialysis are often immunocompromised due to concomitant disease. As a result, this population is at high risk of infection and mortality from COVID-19. In addition to symptomatic treatment, a series of antiviral dru
Externí odkaz:
https://doaj.org/article/00ebbe76c2a5478590aa5cc839c26aa6
Publikováno v:
Rice, Vol 16, Iss 1, Pp 1-17 (2023)
Abstract Background As climate change events become more frequent, drought is an increasing threat to agricultural production and food security. Crop rhizosphere microbiome and root exudates are critical regulators for drought adaptation, yet our und
Externí odkaz:
https://doaj.org/article/f2f841388aae4f92987c1e2eb28fcf08
Autor:
Lamei Cheng, Siqi Wang, Cong Peng, Xiao Zou, Chao Yang, Hua Mei, Chuang Li, Xian Su, Na Xiao, Qi Ouyang, Mi Zhang, Qiaolin Wang, Yan Luo, Minxue Shen, Qun Qin, Honglin Wang, Wu Zhu, Guangxiu Lu, Ge Lin, Yehong Kuang, Xiang Chen
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-11 (2022)
Abstract Psoriasis is a common, chronic immune-mediated systemic disease that had no effective and durable treatment. Mesenchymal stem cells (MSCs) have immunomodulatory properties. Therefore, we performed a phase 1/2a, single-arm clinical trial to e
Externí odkaz:
https://doaj.org/article/f0256af0ef59406f806700b73c01d9e1
Autor:
Ting Zou, Jun-Yan Liu, Qun Qin, Jie Guo, Wen-Zhi Zhou, Xiang-Ping Li, Hong-Hao Zhou, Juan Chen, Zhao-Qian Liu
Publikováno v:
Biomedicines, Vol 11, Iss 12, p 3133 (2023)
Background: Lung cancer is still the most lethal malignancy in the world, according to the report of Cancer Statistics in 2021. Platinum-based chemotherapy combined with immunotherapy is the first-line treatment in lung cancer patients. However, the
Externí odkaz:
https://doaj.org/article/630db547cdcb4b88868f70de777885e6
Autor:
Zhijie Dai, Ronghua Zhu, Zhifeng Sheng, Guijun Qin, Xianghang Luo, Qun Qin, Chunli Song, Liping Li, Ping Jin, Guoping Yang, Yanxiang Cheng, Danhong Peng, Chong Zou, Lijuan Wang, Jianzhong Shentu, Qin Zhang, Zhe Zhang, Xiang Yan, Pingfei Fang, Qiangyong Yan, Lingfeng Yang, Xiao Fan, Wei Liu, Bo Wu, Rongrong Cui, Xiyu Wu, Yuting Xie, Chang Shu, Kai Shen, Wenhua Wei, Wei Lu, Hong Chen, Zhiguang Zhou
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
SHR-1222, a novel humanized monoclonal antibody targeting sclerostin, has been shown to induce bone formation and decrease bone resorption at a single dose ranging 50–400 mg in our previous phase 1 trial. This study was a randomized, double-blind,
Externí odkaz:
https://doaj.org/article/a89e55f5717f475a9a05befd69d69692
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
IntroductionThe ASTRUM-005 trial (NCT04063163) revealed that combination serplulimab plus chemotherapy (etoposide and carboplatin [EC]) treatment was associated with survival advantages relative to chemotherapy alone in patients diagnosed with extens
Externí odkaz:
https://doaj.org/article/c82a0b4ced7a4c4db7f5634ad6389951
Autor:
Jie Guo, Xiaolei Hu, Jing Wang, Bin Yu, Juan Li, Jianting Chen, Xiaoli Nie, Zhijian Zheng, Shixuan Wang, Qun Qin
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Compound methyl salicylate liniment (Ammeltz) is composed of various components, such as methyl salicylate, menthol, camphor, chlorpheniramine maleate, and thymol. It was approved for listing in China in 2011. The purpose of this phase Ⅳ clinical t
Externí odkaz:
https://doaj.org/article/2256101a372e415c9a7f3883c5a6eb2b
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: In recent years, the rise of antibody–drug conjugates (ADCs) has changed the treatment paradigm for patients with HER2-low advanced breast cancer (ABC). DESTINY-Breast04 (NCT03734029) has demonstrated the antitumor activity of trastuzum
Externí odkaz:
https://doaj.org/article/856333500e3945298c9024d8e634c914
Publikováno v:
Agronomy, Vol 13, Iss 7, p 1708 (2023)
Supplemental irrigation under a ridge-furrow (RF) cropping system is a valuable cropping practice that balances resource efficiency and high crop yield. However, the effects of nitrogen management on crop growth, yield formation, and economic benefit
Externí odkaz:
https://doaj.org/article/faf1a01f58c5442d801f994c9ca095f8