Synthesis and SAR of a series of mGlu7 NAMs based on an ethyl-8-methoxy-4-(4-phenylpiperazin-1-yl)quinoline carboxylate core

Autor: Kalbfleisch, Jacob J., Reed, Carson W., Park, Charlotte, Spearing, Paul K., Quitalig, Marc C., Jenkins, Matthew T., Rodriguez, Alice L., Blobaum, Anna L., Conn, P. Jeffrey, Niswender, Colleen M., Lindsley, Craig W.

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 15 November 2020 30(22)

Discovery of an Orally Bioavailable and Central Nervous System (CNS) Penetrant mGlu7 Negative Allosteric Modulator (NAM) in Vivo Tool Compound: N‑(2-(1H‑1,2...

Autor: Reed, Carson W., Yohn, Samantha E., Washecheck, Jordan P., Roenfanz, Hanna F., Quitalig, Marc C., Luscombe, Vincent B., Jenkins, Matthew T., Rodriguez, Alice L., Engers, Darren W., Blobaum, Anna L., Conn, P. Jeffrey, Niswender, Colleen M., Lindsley, Craig W.

Publikováno v: Journal of Medicinal Chemistry; 2/14/2019, Vol. 62 Issue 2, p1690-1695, 6p

Discovery of an Orally Bioavailable and Central Nervous System (CNS) Penetrant mGlu 7 Negative Allosteric Modulator (NAM) in Vivo Tool Compound: N-(2-(1 H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide (VU6012962).

Autor: Reed CW, Yohn SE, Washecheck JP, Roenfanz HF, Quitalig MC, Luscombe VB, Jenkins MT, Rodriguez AL, Engers DW, Blobaum AL, Conn PJ; Vanderbilt Kennedy Center , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 , United States., Niswender CM; Vanderbilt Kennedy Center , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 , United States., Lindsley CW

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2019 Feb 14; Vol. 62 (3), pp. 1690-1695. Date of Electronic Publication: 2019 Jan 17.