Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Quirijn Vos"'
Publikováno v:
International Immunology. 12:1337-1345
We have previously demonstrated that stimulation of B cells by multivalent membrane Ig cross-linking, using dextran-conjugated anti-IgD mAb (alpha delta-dex), in the presence of cytokines, is an in vitro model for T cell-independent type 2 (TI-2) Ig
Publikováno v:
Immunological Reviews. 176:154-170
Antigens that are expressed on the surface of pathogens in an organized, highly repetitive form can activate specific B cells by cross-linking of antigen receptors in a multivalent fashion. B cells respond to these multivalent antigens in the absence
Autor:
Quirijn Vos, George C. Tsokos, James J. Mond, Andrew Lees, Bruce E. Goeckeritz, Klaus Kuhlbusch
Publikováno v:
European Journal of Immunology. 30:969-973
We coupled a monoclonal anti-human IgD to the gp350 gylcoprotein of Epstein-Barr virus, which has been shown to bind to the complement receptor 2 (CR2), and compared its B cell stimulatory ability to that of anti-Ig and to a multivalent anti-Ig-dextr
Autor:
Quirijn Vos, Gregory J. Dennis, Michael Flora, Clifford M. Snapper, James J. Mond, Bruce E. Goeckeritz, Kim Witherspoon, Dennis M. Klinman, David S. Pisetsky, Andrew Lees
Publikováno v:
International Immunology. 11:1693-1700
We have previously reported that B cells that are activated by multivalent but not bivalent membrane Ig cross-linking ligands synergize with various B cell activators culminating in enhanced B cell proliferation. In this study we asked whether B cell
Autor:
Zheng-Qi Wu, Quirijn Vos, Yi Shen, Andrew Lees, Samuel R. Wilson, David E. Briles, William C. Gause, James J. Mond, Clifford M. Snapper
Publikováno v:
The Journal of Immunology. 163:659-667
In vivo Ig responses to soluble, haptenated polysaccharide (PS) Ags are T cell independent and do not require CD40 ligand (CD40L). However, little is known regarding the regulation of in vivo PS-specific Ig responses to intact bacteria. We immunized
Autor:
Clifford M. Snapper, Michele D. Vos, Michelle Conan-Cibotti, Ilan Prager, Steven K. Anderson, John R. Ortaldo, Howard A. Young, Quirijn Vos, James J. Mond, Kim Witherspoon
Publikováno v:
International Immunology. 10:1093-1101
NK cells not only function as cytotoxic effector cells, but also have immunoregulatory roles including the enhancement of Ig secretion. To have a stable and uniform population of NK cells to study their role in Ig secretion, we generated murine NK cl
Publikováno v:
Current Opinion in Immunology. 7:349-354
T cell independent antigens type 2 (TI-2), which are represented predominantly by polysaccharide antigens, stimulate humoral antibody responses in the absence of T-cell help. We and others have recently reported that natural killer cells and/or natur
Autor:
Richard J. Hodes, Quirijn Vos
Publikováno v:
The Journal of Experimental Medicine
The sera of C57BL/6 mice transgenic for a mu a allotype heavy (H) chain and kappa light chain gene contained endogenous nontransgene immunoglobulin (IgM) (mu b allotype) and IgA molecules which carried the idiotype expressed by the transgenically enc
Autor:
Quirijn Vos, Ligia M.T. Peçanha, James J. Mond, Lucia Mendonça Previato, Luciana B. de Arruda Hinds, José O. Previato
Publikováno v:
Infection and immunity. 67(11)
Glycoinositolphospholipids (GIPLs) are some of the major glycolipids of the Trypanosoma cruzi surface that were previously shown to activate B cells. In the present study, we investigated whether (i) T. cruzi GIPLs could induce immunoglobulin secreti
Publikováno v:
International immunology. 11(2)
We recently described a panel of cytotoxic murine NK cell clones that also enhanced Ig secretion by B cells activated in an in vitro model of T cell-independent type 2 (TI-2) responses. We employed dextran-conjugated anti-IgD (alphadelta-dex) as a mo