Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Quinton L. Fivelman"'
Autor:
Louisa McRobert, Cathy J Taylor, Wensheng Deng, Quinton L Fivelman, Ross M Cummings, Spencer D Polley, Oliver Billker, David A Baker
Publikováno v:
PLoS Biology, Vol 6, Iss 6, p e139 (2008)
Malaria parasite transmission requires differentiation of male and female gametocytes into gametes within a mosquito following a blood meal. A mosquito-derived molecule, xanthurenic acid (XA), can trigger gametogenesis, but the signalling events cont
Externí odkaz:
https://doaj.org/article/1b434b20175d41168a2c7a87c04c88a9
Autor:
Quinton L. Fivelman, Shamshad Cockcroft, Paul W. Bowyer, David A. Baker, Alison Skippen, Werner Leber
Publikováno v:
International Journal for Parasitology. 39:645-653
In eukaryotes, calcium signalling has been linked to hydrolysis of the phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)). The final enzyme in the synthesis of this phosphoinositide, a Type I phosphatidylinositol 4-phosphate 5-kinase (PIP5K), is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66135374c1bfd77ae0397e87f1e2dde4
https://doi.org/10.1016/j.ijpara.2008.11.015
https://doi.org/10.1016/j.ijpara.2008.11.015
Autor:
Cathy J. Taylor, Quinton L. Fivelman, Sarah Sharp, Colin J. Sutherland, Louisa McRobert, Claire A. Swales, Maha Saeed, David A. Baker
Publikováno v:
Molecular and Biochemical Parasitology. 154:119-123
The sexual stages of the Plasmodium falciparum life cycle are attractive targets for vaccines and transmission blocking drugs. Difficulties in culturing and obtaining large amounts of sexual stage P. falciparum parasites, particularly early stages, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1e66ca10eeaf34f25c8820a4e2be13
https://doi.org/10.1016/j.molbiopara.2007.04.008
https://doi.org/10.1016/j.molbiopara.2007.04.008
Autor:
David C. Warhurst, Quinton L. Fivelman, I.S. Adagu, R. Kiplin Guy, John C. Craig, Peter B. Madrid
Publikováno v:
Biochemical Pharmacology. 73:1910-1926
Chloroquine (CQ), a 4-aminoquinoline, accumulates in acidic digestive vacuoles of the malaria parasite, preventing conversion of toxic haematin to beta-haematin. We examine how bis 4-aminoquinoline piperaquine (PQ) and its hydroxy-modification (OH-PQ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c876b668e9afde6a406cbd5837cd39c5
https://doi.org/10.1016/j.bcp.2007.03.011
https://doi.org/10.1016/j.bcp.2007.03.011
Autor:
Peter L. Blair, Yingyao Zhou, Karine G. Le Roch, Jason A. Young, Quinton L. Fivelman, Patricia de la Vega, Daniel J. Carucci, Elizabeth A. Winzeler, David A. Baker
Publikováno v:
Molecular and Biochemical Parasitology. 143:67-79
The sexual stages of malarial parasites are essential for the mosquito transmission of the disease and therefore are the focus of transmissionblocking drug and vaccine development. In order to better understand genes important to the sexual developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c568688c242d253570a2680439633ff4
https://doi.org/10.1016/j.molbiopara.2005.05.007
https://doi.org/10.1016/j.molbiopara.2005.05.007
Publikováno v:
Antimicrobial Agents and Chemotherapy. 48:4097-4102
A modified fixed-ratio isobologram method for studying the in vitro interactions between antiplasmodial drugs is described. This method was used to examine the interactions between atovaquone, proguanil, and dihydroartemisinin. The interaction betwee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29697ef2334962503d94374a95d6702e
https://doi.org/10.1128/aac.48.11.4097-4102.2004
https://doi.org/10.1128/aac.48.11.4097-4102.2004
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:2265-2267
Piperaquine is being developed as a long-acting component in artemisinin combination therapies. It was highly active in vitro and drug interaction studies showed that dihydroartemisinin combinations with piperaquine, chloroquine, and amodiaquine were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f00dc80436aa6b8db5dba928025039
https://doi.org/10.1128/aac.01479-06
https://doi.org/10.1128/aac.01479-06
Autor:
Quinton L. Fivelman, Cathy J. Taylor, Helen M. Taylor, Wensheng Deng, David Baker, Munira Grainger, Oliver Billker, Spencer D. Polley, Louisa McRobert, Anthony A. Holder, Audrey Sicard, Robert W. Moon
Publikováno v:
BMC Pharmacology
The life cycle of the malaria parasite Plasmodium is complex with distinct phases occurring in the human host and the mosquito vector. Proliferation of asexual parasites within blood cells leads to pathology whereas a distinct sexual stage is require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6518883c65abab7c659bc55fb9fa669
https://doi.org/10.1186/1471-2210-9-s1-s2
https://doi.org/10.1186/1471-2210-9-s1-s2
Autor:
Lisa C. Ranford-Cartwright, James A. Brannigan, Quinton L. Fivelman, Shane R. Wilkinson, Anthony J. Wilkinson, Spencer D. Polley, David A. Baker, Claudia Schnick
Publikováno v:
Molecular Microbiology
Malaria pathology is caused by multiplication of asexual parasites within erythrocytes, whereas mosquito transmission of malaria is mediated by sexual precursor cells (gametocytes). Microarray analysis identified glycerol kinase (GK) as the second mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eafa42b58e52ff9096ddc76b48384a4
https://pubmed.ncbi.nlm.nih.gov/19040641
https://pubmed.ncbi.nlm.nih.gov/19040641