Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals

Autor: Nead, Kevin T., Li, Aihua, Wehner, Mackenzie R., Neupane, Binod, Gustafsson, Stefan, Butterworth, Adam, Engert, James C., Davis, A. Darlene, Hegele, Robert A., Miller, Ruby, den Hoed, Marcel, Khaw, Kay-Tee, Kilpeläinen, Tuomas O., Wareham, Nick, Edwards, Todd L., Hallmans, Göran, Varga, TiborV., Kardia, SharonL.R., Smith, Jennifer A., Zhao, Wei, Faul, Jessica D., Weir, David, Mi, Jie, Xi, Bo, Quinteros, Samuel Canizales, Cooper, Cyrus, Sayer, Avan Aihie, Jameson, Karen, Grøntved, Anders, Fornage, Myriam, Sidney, Stephen, Hanis, Craig L., Highland, Heather M., Häring, Hans-Ulrich, Heni, Martin, Lasky-Su, Jessica, Weiss, Scott T., Gerhard, Glenn S., Still, Christopher, Melka, Melkaey M., Pausova, Zdenka, Paus, Tomáš, Grant, Struan F.A., Hakonarson, Hakon, Price, R Arlen, Wang, Kai, Scherag, Andre, Hebebrand, Johannes, Hinney, Anke, BioBank Japan, AGEN-BMI, GIANT Consortium, Franks, Paul W., Frayling, Timothy M., McCarthy, Mark I., Hirschhorn, Joel N., Loos, Ruth, Ingelsson, Erik, Gerstein, Hertzel C., Yusuf, Salim, Beyene, Joseph, Anand, Sonia S., Meyre, David

Publikováno v: Nead, K T, Li, A, Wehner, M R, Neupane, B, Gustafsson, S, Butterworth, A, Engert, J C, Davis, A D, Hegele, R A, Miller, R, den Hoed, M, Khaw, K-T, Kilpeläinen, T O, Wareham, N, Edwards, T L, Hallmans, G, Varga, T V, Kardia, S L R, Smith, J A, Zhao, W, Faul, J D, Weir, D, Mi, J, Xi, B, Quinteros, S C, Cooper, C, Sayer, A A, Jameson, K, Grøntved, A, Fornage, M, Sidney, S, Hanis, C L, Highland, H M, Häring, H-U, Heni, M, Lasky-Su, J, Weiss, S T, Gerhard, G S, Still, C, Melka, M M, Pausova, Z, Paus, T, Grant, S F A, Hakonarson, H, Price, R A, Wang, K, Scherag, A, Hebebrand, J, Hinney, A, Franks, P W & BioBank Japan, AGEN-BMI, GIANT Consortium 2015, ' Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity : a systematic review and meta-analysis with evidence from up to 331 175 individuals ', Human Molecular Genetics, vol. 24, no. 12, pp. 3582-3594 . https://doi.org/10.1093/hmg/ddv097
Hum. Mol. Genet. 24, 3582-3594 (2015)

Polymorphisms rs6232 and rs6234/rs6235 in PCSK1 have been associated with extreme obesity [e.g. body mass index (BMI) ≥ 40 kg/m(2)], but their contribution to common obesity (BMI ≥ 30 kg/m(2)) and BMI variation in a multi-ethnic context is unclea

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https://europepmc.org/articles/PMC4498155/