Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat

Autor: Labi, V., Peng, S., Klironomos, F., Munschauer, M., Kastelic, N., Chakraborty, T., Schoeler, K., Derudder, E., Martella, M., Mastrobuoni, G., Hernandez-Miranda, L.R., Lahmann, I., Kocks, C., Birchmeier, C., Kempa, S., Quintanilla-Martinez de Fend, L., Landthaler, M., Rajewsky, N., Rajewsky, K.

Knockout of the ubiquitously expressed miRNA-17~92 cluster in mice produces a lethal developmental lung defect, skeletal abnormalities, and blocked B lymphopoiesis. A shared target of miR-17~92 miRNAs is the pro-apoptotic protein BIM, central to life

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=mdc______med::2331b43be57747ee6ebc62af1977a2eb
http://edoc.mdc-berlin.de/18515/1/18515oa.pdf

Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat.

Autor: Labi V; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin-Buch 13125, Germany.; Program of Cellular and Molecular Medicine, Children's Hospital, and Immune Disease Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.; Division of Developmental Immunology, Biocenter, Medical University of Innsbruck, Innsbruck 6020, Austria., Peng S; Program of Cellular and Molecular Medicine, Children's Hospital, and Immune Disease Institute, Harvard Medical School, Boston, Massachusetts 02115, USA., Klironomos F; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin-Buch 13125, Germany.; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin-Buch 13125, Germany., Munschauer M; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin-Buch 13125, Germany.; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin-Buch 13125, Germany., Kastelic N; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin-Buch 13125, Germany.; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin-Buch 13125, Germany., Chakraborty T; Program of Cellular and Molecular Medicine, Children's Hospital, and Immune Disease Institute, Harvard Medical School, Boston, Massachusetts 02115, USA., Schoeler K; Division of Developmental Immunology, Biocenter, Medical University of Innsbruck, Innsbruck 6020, Austria., Derudder E; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin-Buch 13125, Germany.; Program of Cellular and Molecular Medicine, Children's Hospital, and Immune Disease Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.; Institute for Biomedical Ageing Research, University of Innsbruck, Innsbruck 6020, Austria., Martella M; Institute of Pathology and Neuropathology and Comprehensive Cancer Center Tübingen, Eberhard-Karls-University, Tübingen 72076, Germany., Mastrobuoni G; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin-Buch 13125, Germany.; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin-Buch 13125, Germany., Hernandez-Miranda LR; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin-Buch 13125, Germany., Lahmann I; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin-Buch 13125, Germany., Kocks C; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin-Buch 13125, Germany.; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin-Buch 13125, Germany., Birchmeier C; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin-Buch 13125, Germany., Kempa S; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin-Buch 13125, Germany.; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin-Buch 13125, Germany., Quintanilla-Martinez de Fend L; Institute of Pathology and Neuropathology and Comprehensive Cancer Center Tübingen, Eberhard-Karls-University, Tübingen 72076, Germany., Landthaler M; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin-Buch 13125, Germany.; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin-Buch 13125, Germany., Rajewsky N; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin-Buch 13125, Germany.; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin-Buch 13125, Germany., Rajewsky K; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin-Buch 13125, Germany.; Program of Cellular and Molecular Medicine, Children's Hospital, and Immune Disease Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

Publikováno v: Genes & development [Genes Dev] 2019 Dec 01; Vol. 33 (23-24), pp. 1673-1687. Date of Electronic Publication: 2019 Nov 07.