Zobrazeno 1 - 10 of 93 pro vyhledávání: '"Quinolines/*pharmacology"'
1
Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors
Autor: Henry Beetham, Billie G.C. Griffith, Olga Murina, Alexander E.P. Loftus, David A. Parry, Carolin Temps, Jayne Culley, Morwenna Muir, Asier Unciti-Broceta, Andrew H. Sims, Adam Byron, Valerie G. Brunton
Publikováno v: Beetham, H, Griffith, B, Murina, O, Loftus, A, Parry, D A, Temps, C, Culley, J, Muir, M, Unciti-Broceta, A, Sims, A H, Byron, A & Brunton, V G 2021, ' Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors ', Cancer Research . https://doi.org/10.1158/0008-5472.CAN-21-0373
Beetham, H, Griffith, B G C, Murina, O, Loftus, A E P, Parry, D A, Temps, C, Culley, J, Muir, M, Unciti-Broceta, A, Sims, A H, Byron, A & Brunton, V G 2022, ' Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors ', Cancer Research, vol. 82, no. 4, pp. 632-647 . https://doi.org/10.1158/0008-5472.CAN-21-0373
SRC is a nonreceptor tyrosine kinase with key roles in breast cancer development and progression. Despite this, SRC tyrosine kinase inhibitors have so far failed to live up to their promise in clinical trials, with poor overall response rates. We aim
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60490b72d4b6e9896c2cb3f20e716f6
https://www.pure.ed.ac.uk/ws/files/245549967/Loss_of_Integrin_linked_kinase_sensitizes_breast_cancer_to_SRC_inhibitors_published_AAM.pdf
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2
An innovative automated active compound screening system allows high-throughput optimization of somatic embryogenesis in Coffea arabica
Autor: Awada, Rayan, Verdier, Dorothée, Froger, Solène, Brulard, Eric, de Faria Maraschin, Simone, Etienne, Hervé, Breton, David
Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.810. ⟨10.1038/s41598-020-57800-6⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, 2020, 10 (1), pp.810. ⟨10.1038/s41598-020-57800-6⟩
International audience; Somatic embryogenesis (SE) faces many challenges in fulfilling the growing demand for elite materials. A high-throughput approach is required to accelerate the optimization of SE protocols by multiplying experimental condition
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ad560625731b76de1f486cba55a1089c
https://hal.umontpellier.fr/hal-03454869
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3
Ammonium accumulation is a primary effect of 2-methylcitrate exposure in an in vitro model for brain damage in methylmalonic aciduria
Autor: Hugues Henry, Olivier Braissant, Sónia do Vale-Pereira, Julijana Ivanisevic, Noémie Remacle, Denise Tavel, Diana Ballhausen, Hong-Phuc Cudré-Cung, Petra Zavadakova
Publikováno v: Molecular genetics and metabolism, vol. 119, no. 1-2, pp. 57-67
Using 3D organotypic rat brain cell cultures in aggregates we recently identified 2-methylcitrate (2-MCA) as the main toxic metabolite for developing brain cells in methylmalonic aciduria. Exposure to 2-MCA triggered morphological changes and apoptos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d03dd985c8ab99f322eec2b8b7c870b
https://doi.org/10.1016/j.ymgme.2016.07.013
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4
The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression in SIV-infected rhesus macaques
Autor: Guido Silvestri, Julie Garibal, Vasco Rodrigues, Alain Pruvost, Shahul Mouhamad, Mireille Laforge, Valérie Monceaux, Jérôme Estaquier, Anna Senik, Bruno Hurtrel, Henintsoa Rabezanahary, Ricardo Silvestre, Anabela Cordeiro-da-Silva, Laure Campillo-Gimenez, Marie-Christine Cumont
Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2018, 128 (4), pp.1627-1640. ⟨10.1172/JCI95127⟩
Apoptosis has been proposed as a key mechanism responsible for CD4+ T cell depletion and immune dysfunction during HIV infection. We demonstrated that Q-VD-OPH, a caspase inhibitor, inhibits spontaneous and activation-induced death of T cells from SI
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a722532b12bdd83ff678a61fe5e8c8
https://europepmc.org/articles/PMC5873886/
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5
Investigation of the role of GBF1 in the replication of positive-sense single-stranded RNA viruses
Autor: Laurence Cocquerel, Yves Rouillé, Didier Hober, Rayan Farhat, Sandrine Belouzard, Juliette Ferlin, Antoine Bertin, Jean Dubuisson
Publikováno v: Journal of General Virology
Journal of General Virology, Microbiology Society, 2018, 99 (8), pp.1086-1096. ⟨10.1099/jgv.0.001099⟩
Journal of General Virology, 2018, 99 (8), pp.1086-1096. ⟨10.1099/jgv.0.001099⟩
International audience; GBF1 has emerged as a host factor required for the replication of positive-sense single-stranded RNA viruses of different families, but its mechanism of action is still unknown. GBF1 is a guanine nucleotide exchange factor for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f61a159d161901a3885c57f1e24dc7b
https://hal.archives-ouvertes.fr/hal-02113930
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6
Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 5 (Nox5) Regulation by Angiotensin II and Endothelin-1 Is Mediated via Calcium/Calmodulin-Dependent, Rac-1-Independent Pathways in Human Endothelial Cells
Autor: Dylan Burger, Rhian M. Touyz, Augusto C. Montezano, Mahmoud Almasri, Mark T. Quinn, Hiba Yusuf, Gang He, David Lambeth, Ying He, Glaucia E. Callera, Karl-Heinz Krause, Andreia Z. Chignalia, Tamara M. Paravicini
Publikováno v: Circulation Research, Vol. 106, No 8 (2010) pp. 1363-1373
Circulation research
Rationale : Although Nox5 (Nox2 homolog) has been identified in the vasculature, its regulation and functional significance remain unclear. Objectives : We sought to test whether vasoactive agents regulate Nox5 through Ca 2+ /calmodulin-dependent pro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1679ba131fe58d4c38004afdf7734fa
https://doi.org/10.1161/circresaha.109.216036
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7
Pyrroloquinoline quinone prevents oxidative stress-induced neuronal death probably through changes in oxidative status of DJ-1
Autor: Kana Nunome, Shin Miyazaki, Hiroyoshi Ariga, Sanae M.M. Iguchi-Ariga, Masahiko Nakano
Publikováno v: Biological & pharmaceutical bulletin. 31(7):1321-1326
Pyrroloquinoline quinone (PQQ) has been shown to play a role as an anti-oxidant in neuronal cells and prevent neuronal cell death in a rodent stroke model. DJ-1, a causative gene product for a familial form of Parkinson's disease, plays a role in ant
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2cdd57dbe2e86aba2675327cfe637bf
http://hdl.handle.net/2115/53726
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9
Somatostatin receptors in the ventral pallidum/substantia innominata modulate rat locomotor activity
Autor: A. Marazioti, D. Papasava, Andreas Kastellakis, Katerina Antoniou, Kyriaki Thermos
Publikováno v: Psychopharmacology. 181:319-326
RATIONALE: Somatostatin and its receptors (sst(1) and sst(2)) have been localized in brain nuclei implicated in motor control, such as the nucleus accumbens, ventral pallidum (VP) and substantia innominata (SI). OBJECTIVES: The objective of the study
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ffaabbf42c96b7887d0e873c6b9d4d
https://doi.org/10.1007/s00213-005-2237-z
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