Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Quinn S Wells"'
Autor:
Shi Huang, Joshua A Beckman, Eric Farber-Eger, Quinn S Wells, Timothy E Thayer, Evan L Brittain, Jonathan D Mosley
Publikováno v:
Open Heart, Vol 8, Iss 2 (2021)
Externí odkaz:
https://doaj.org/article/289da3ba3f394200a4ae9f212d7307dc
Precision nicotine metabolism-informed care for smoking cessation in Crohn's disease: A pilot study.
Autor:
Elizabeth A Scoville, Hilary A Tindle, Quinn S Wells, Shannon C Peyton, Shelly Gurwara, Stephanie O Pointer, Sara N Horst, David A Schwartz, Dawn W Adams, Matthew S Freiberg, Vanessa Gatskie, Stephen King, Lesa R Abney, Dawn B Beaulieu
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0230656 (2020)
IntroductionSmoking is a strong risk factor for disease severity in Crohn's disease (CD) and cessation improves outcomes. The nicotine metabolite ratio (NMR) predicts cessation success with pharmacotherapy: varenicline doubles cessation over nicotine
Externí odkaz:
https://doaj.org/article/3a70b9d4295e41a480d2c2d27ccfe6c2
Autor:
Christi T Salisbury-Ruf, Clinton C Bertram, Aurelia Vergeade, Daniel S Lark, Qiong Shi, Marlene L Heberling, Niki L Fortune, G Donald Okoye, W Gray Jerome, Quinn S Wells, Josh Fessel, Javid Moslehi, Heidi Chen, L Jackson Roberts II, Olivier Boutaud, Eric R Gamazon, Sandra S Zinkel
Publikováno v:
eLife, Vol 7 (2018)
Bcl-2 family proteins reorganize mitochondrial membranes during apoptosis, to form pores and rearrange cristae. In vitro and in vivo analysis integrated with human genetics reveals a novel homeostatic mitochondrial function for Bcl-2 family protein B
Externí odkaz:
https://doaj.org/article/713e95df63974051b6c65861bd7d12a1
Autor:
David Carmona-Berrio, Isabel Adarve-Rengifo, Andrea G. Marshall, Zer Vue, Duane D. Hall, Tyne W. Miller-Fleming, Ky’Era V. Actkins, Heather K. Beasley, Paula M. Almonacid, Pierina Barturen-Larrea, Quinn S. Wells, Marcos G. Lopez, Edgar Garza-Lopez, Dao-Fu Dai, Jianqiang Shao, Kit Neikirk, Frederic T. Billings, IV, John A. Curci, Nancy J. Cox, Vivian Gama, Antentor Hinton, Jr., Jose A. Gomez
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110436- (2024)
Summary: Abdominal and thoracic aortic aneurysms (AAAs, TAAs) remain a major cause of deaths worldwide, in part due to the lack of reliable prognostic markers or early warning signs. Sox6 has been found to regulate renin controlling blood pressure. W
Externí odkaz:
https://doaj.org/article/10fbddafdd5e4e57aba0f987d45fef4e
Autor:
Scott S. Lee, Nicole Senft Everson, Maureen Sanderson, Rebecca Selove, William J. Blot, Stephen King, Karen Gilliam, Suman Kundu, Mark Steinwandel, Sarah J. Sternlieb, Qiuyin Cai, Shaneda Warren Andersen, Debra L. Friedman, Erin Connors Kelly, Mary Kay Fadden, Matthew S. Freiberg, Quinn S. Wells, Juan Canedo, Rachel F. Tyndale, Robert P. Young, Raewyn J. Hopkins, Hilary A. Tindle
Publikováno v:
Addiction Science & Clinical Practice, Vol 19, Iss 1, Pp 1-12 (2024)
Abstract Background The feasibility of precision smoking treatment in socioeconomically disadvantaged communities has not been studied. Methods Participants in the Southern Community Cohort Study who smoked daily were invited to join a pilot randomiz
Externí odkaz:
https://doaj.org/article/d106c37905634403b939d73fc60e9ef6
Autor:
Jonathan D Mosley, Sara L Van Driest, Peter E Weeke, Jessica T Delaney, Quinn S Wells, Lisa Bastarache, Dan M Roden, Josh C Denny
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100322 (2014)
The coupling of electronic medical records (EMR) with genetic data has created the potential for implementing reverse genetic approaches in humans, whereby the function of a gene is inferred from the shared pattern of morbidity among homozygotes of a
Externí odkaz:
https://doaj.org/article/e89e97a460d741b89a7ed6c0723dfce1
Autor:
Jonathan D Mosley, Sara L Van Driest, Emma K Larkin, Peter E Weeke, John S Witte, Quinn S Wells, Jason H Karnes, Yan Guo, Lisa Bastarache, Lana M Olson, Catherine A McCarty, Jennifer A Pacheco, Gail P Jarvik, David S Carrell, Eric B Larson, David R Crosslin, Iftikhar J Kullo, Gerard Tromp, Helena Kuivaniemi, David J Carey, Marylyn D Ritchie, Josh C Denny, Dan M Roden
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81503 (2013)
A single mutation can alter cellular and global homeostatic mechanisms and give rise to multiple clinical diseases. We hypothesized that these disease mechanisms could be identified using low minor allele frequency (MAF
Externí odkaz:
https://doaj.org/article/0f6b6da6da1d4ddf9b51b5dedbf40ee6
Autor:
Majd A. El‐Harasis, Joseph A. Quintana, J. Roberto Martinez‐Parachini, Gregory G. Jackson, Bibin T. Varghese, Zachary T. Yoneda, Brittany S. Murphy, Diane M. Crawford, Kelsey Tomasek, Yan Ru Su, Quinn S. Wells, Dan M. Roden, Gregory F. Michaud, Pablo Saavedra, Juan Carlos Estrada, Travis D. Richardson, Arvindh N. Kanagasundram, Sharon T. Shen, Jay A. Montgomery, Christopher R. Ellis, George H. Crossley, Magdalena Eberl, Ludovic Gillet, Andre Ziegler, M. Benjamin Shoemaker
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 6 (2024)
Background Recurrence after atrial fibrillation (AF) ablation remains common. We evaluated the association between recurrence and levels of biomarkers of cardiac remodeling, and their ability to improve recurrence prediction when added to a clinical
Externí odkaz:
https://doaj.org/article/ecdb8da2b6da41c1b21abdfd26c10dbc
Autor:
Kevin R. Bersell, Tao Yang, Jonathan D. Mosley, Andrew M. Glazer, Andrew T. Hale, Dmytro O. Kryshtal, Kyungsoo Kim, Jeffrey D. Steimle, Jonathan D. Brown, Joe-Elie Salem, Courtney C. Campbell, Charles C. Hong, Quinn S. Wells, Amanda N. Johnson, Laura Short, Marcia A. Blair, Elijah R. Behr, Evmorfia Petropoulou, Yalda Jamshidi, Mark D. Benson, Michelle J. Keyes, Debby Ngo, Ramachandran S. Vasan, Qiong Yang, Robert E. Gerszten, Christian Shaffer, Shan Parikh, Quanhu Sheng, Prince J. Kannankeril, Ivan P. Moskowitz, John D. York, Thomas J. Wang, Bjorn C. Knollmann, Dan M. Roden
Publikováno v:
Circulation. 147:824-840
Background: Brugada syndrome (BrS) is an inherited arrhythmia syndrome caused by loss-of-function variants in the cardiac sodium channel gene SCN5A (sodium voltage-gated channel alpha subunit 5) in ≈20% of subjects. We identified a family with 4 in
Autor:
Patrick M. Kozak, Meng Xu, Eric Farber‐Eger, David Gailani, Quinn S. Wells, Joshua A. Beckman
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 22 (2019)
Background The value of thrombophilia test acquisition in improving risk prediction beyond clinical presentation remains unknown. We investigated the effect of thrombophilia test acquisition on venous thromboembolism (VTE) outcomes. Methods and Resul
Externí odkaz:
https://doaj.org/article/c051f74baa274dd1b47b1b16d2edc79d