Multiscale, multimodal analysis of tumor heterogeneity in IDH1 mutant vs wild-type diffuse gliomas.

Autor: Michael E Berens, Anup Sood, Jill S Barnholtz-Sloan, John F Graf, Sanghee Cho, Seungchan Kim, Jeffrey Kiefer, Sara A Byron, Rebecca F Halperin, Sara Nasser, Jonathan Adkins, Lori Cuyugan, Karen Devine, Quinn Ostrom, Marta Couce, Leo Wolansky, Elizabeth McDonough, Shannon Schyberg, Sean Dinn, Andrew E Sloan, Michael Prados, Joanna J Phillips, Sarah J Nelson, Winnie S Liang, Yousef Al-Kofahi, Mirabela Rusu, Maria I Zavodszky, Fiona Ginty

Publikováno v: PLoS ONE, Vol 14, Iss 12, p e0219724 (2019)

Glioma is recognized to be a highly heterogeneous CNS malignancy, whose diverse cellular composition and cellular interactions have not been well characterized. To gain new clinical- and biological-insights into the genetically-bifurcated IDH1 mutant

Externí odkaz: https://doaj.org/article/1e809134b36d47c88e669627661aa0b7

Genome-wide methylation analyses in glioblastoma multiforme.

Autor: Rose K Lai, Yanwen Chen, Xiaowei Guan, Darryl Nousome, Charu Sharma, Peter Canoll, Jeffrey Bruce, Andrew E Sloan, Etty Cortes, Jean-Paul Vonsattel, Tao Su, Lissette Delgado-Cruzata, Irina Gurvich, Regina M Santella, Quinn Ostrom, Annette Lee, Peter Gregersen, Jill Barnholtz-Sloan

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e89376 (2014)

Few studies had investigated genome-wide methylation in glioblastoma multiforme (GBM). Our goals were to study differential methylation across the genome in gene promoters using an array-based method, as well as repetitive elements using surrogate gl

Externí odkaz: https://doaj.org/article/5272d5c08b314dfeba165348f82de440

The association between genetically elevated polyunsaturated fatty acids and risk of cancer

Autor: Philip C. Haycock, Maria Carolina Borges, Kimberley Burrows, Rozenn N. Lemaitre, Stephen Burgess, Nikhil K. Khankari, Konstantinos K. Tsilidis, Tom R. Gaunt, Gibran Hemani, Jie Zheng, Therese Truong, Brenda M. Birmann, Tracy OMara, Amanda B. Spurdle, Mark M. Iles, Matthew H. Law, Susan L. Slager, Fatemeh Saberi Hosnijeh, Daniela Mariosa, Michelle Cotterchio, James R. Cerhan, Ulrike Peters, Stefan Enroth, Puya Gharahkhani, Loic Le Marchand, Ann C. Williams, Robert C. Block, Christopher I. Amos, Rayjean J. Hung, Wei Zheng, Marc J. Gunter, George Davey Smith, Caroline Relton, Richard M. Martin, Nathan Tintle, Terri Rice, Iona Cheng, Mark Jenkins, Steve Gallinger, Alex J. Cornish, Amit Sud, Jayaram Vijayakrishnan, Margaret Wrensch, Mattias Johansson, Aaron D. Norman, Alison Klein, Alyssa Clay-Gilmour, Andre Franke, Andres V. Ardisson Korat, Bill Wheeler, Björn Nilsson, Caren Smith, Chew-Kiat Heng, Ci Song, David Riadi, Elizabeth B. Claus, Eva Ellinghaus, Evgenia Ostroumova, null Hosnijeh, Florent de Vathaire, Giovanni Cugliari, Giuseppe Matullo, Irene Oi-Lin Ng, Jeanette E. Passow, Jia Nee Foo, Jiali Han, Jianjun Liu, Jill Barnholtz-Sloan, Joellen M. Schildkraut, John Maris, Joseph L. Wiemels, Kari Hemminki, Keming Yang, Lambertus A. Kiemeney, Lang Wu, Laufey Amundadottir, Marc-Henri Stern, Marie-Christine Boutron, Mark Martin Iles, Mark P. Purdue, Martin Stanulla, Melissa Bondy, Mia Gaudet, Lenha Mobuchon, Nicola J. Camp, Pak Chung Sham, Pascal Guénel, Paul Brennan, Philip R. Taylor, Quinn Ostrom, Rachael Stolzenberg-Solomon, Rajkumar Dorajoo, Richard Houlston, Robert B. Jenkins, Sharon Diskin, Sonja I. Berndt, Spiridon Tsavachidis, Stephen J. Channock, Tabitha Harrison, Tessel Galesloot, Ulf Gyllensten, Vijai Joseph, Y. Shi, Wenjian Yang, Yi Lin, Stephen K. Van Den Eeden

Publikováno v: Haycock, P C, Borges, M C, Burrows, K, Gaunt, T R, Hemani, G, Williams, A C, Davey Smith, G, Relton, C L & Martin, R M 2023, ' The association between genetically elevated polyunsaturated fatty acids and risk of cancer ', EBioMedicine, vol. 91, 104510 . https://doi.org/10.1016/j.ebiom.2023.104510

BackgroundThe causal relevance of polyunsaturated fatty acids (PUFAs) for risk of site-specific cancers remains uncertain.MethodsUsing a Mendelian randomization (MR) framework, we assessed the causal relevance of PUFAs for risk of cancer in European

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e902eeee7d75ecf1a6cf94541789012e
https://research-information.bris.ac.uk/en/publications/7cd08dd1-622d-4072-b9f5-dc6bdf4f3c0f

EPID-11. NATIONAL EPIDEMIOLOGY AND SURVIVAL OF ADULT-TYPE DIFFUSE GLIOMAS IN THE UNITED STATES BY IDH, 1P/19Q, MGMT, AND WHO CNS GRADE

Autor: Bryan Iorgulescu, Chuxuan Sun, Gino Cioffi, Corey Neff, Madison Shoaf, Kristin Waite, Carol Kruchko, Patrick Y Wen, Daniel Brat, Quinn Ostrom, Jill Barnholtz-Sloan

Publikováno v: Neuro-Oncology. 24:vii111-vii112

BACKGROUND Histomolecularly-defined adult-type diffuse gliomas—including IDH-wildtype glioblastoma, IDH-mutant astrocytoma, and IDH-mutant 1p/19q-codeleted oligodendroglioma—were incorporated into U.S. cancer registry reporting for individuals wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96edb6a2537de37de1309668e2af960f
https://doi.org/10.1093/neuonc/noac209.421

EPID-19. CHANGES IN SURVIVAL OVER TIME FOR ALL PRIMARY BRAIN AND OTHER CNS TUMORS IN THE UNITED STATES

Autor: Jacob Edelson, Kristin Waite, Gino Cioffi, Carol Kruchko, Quinn Ostrom, Jill Barnholtz-Sloan

Publikováno v: Neuro-Oncology. 24:vii113-vii113

BACKGROUND Despite advances in cancer diagnosis and clinical care, survival for many primary brain and other central nervous system (CNS) tumors remain poor. This study performs a comprehensive survival analysis on these tumors. METHODS Survival diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc07ed5cc5b0e7e87be61c7d97860924
https://doi.org/10.1093/neuonc/noac209.429