Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Quinn Lu"'
Autor:
Carl A. Machutta, Christopher S. Kollmann, Kenneth E. Lind, Xiaopeng Bai, Pan F. Chan, Jianzhong Huang, Lluis Ballell, Svetlana Belyanskaya, Gurdyal S. Besra, David Barros-Aguirre, Robert H. Bates, Paolo A. Centrella, Sandy S. Chang, Jing Chai, Anthony E. Choudhry, Aaron Coffin, Christopher P. Davie, Hongfeng Deng, Jianghe Deng, Yun Ding, Jason W. Dodson, David T. Fosbenner, Enoch N. Gao, Taylor L. Graham, Todd L. Graybill, Karen Ingraham, Walter P. Johnson, Bryan W. King, Christopher R. Kwiatkowski, Joël Lelièvre, Yue Li, Xiaorong Liu, Quinn Lu, Ruth Lehr, Alfonso Mendoza-Losana, John Martin, Lynn McCloskey, Patti McCormick, Heather P. O’Keefe, Thomas O’Keeffe, Christina Pao, Christopher B. Phelps, Hongwei Qi, Keith Rafferty, Genaro S. Scavello, Matt S. Steiginga, Flora S. Sundersingh, Sharon M. Sweitzer, Lawrence M. Szewczuk, Amy Taylor, May Fern Toh, Juan Wang, Minghui Wang, Devan J. Wilkins, Bing Xia, Gang Yao, Jean Zhang, Jingye Zhou, Christine P. Donahue, Jeffrey A. Messer, David Holmes, Christopher C. Arico-Muendel, Andrew J. Pope, Jeffrey W. Gross, Ghotas Evindar
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Encoded Library Technology (ELT) has streamlined the identification of chemical ligands for protein targets in drug discovery. Here, the authors optimize the ELT approach to screen multiple proteins in parallel and identify promising targets and anti
Externí odkaz:
https://doaj.org/article/a0c4424f2eeb46a689586e4828ae7887
Autor:
Xin Zeng, Robert Kirkpatrick, Glenn Hofmann, Didier Grillot, Valerie Linhart, Fabrice Viviani, Joseph Marino, Joseph Boyer, Taylor L Graham, Quinn Lu, Zining Wu, Andrew Benowitz, Rick Cousins
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0207140 (2018)
Atonal homolog 1 (Atoh1) is a basic helix-loop-helix 9 (bHLH) transcription factor acting downstream of Notch and is required for the differentiation of sensory hair cells in the inner ear and the specification of secretory cells during the intestina
Externí odkaz:
https://doaj.org/article/656109b149fa41a9b622668bf276f068
Autor:
Pu Qin, Pelin Arabacilar, Roberta E. Bernard, Weike Bao, Alan R. Olzinski, Yuanjun Guo, Hind Lal, Stephen H. Eisennagel, Michael C. Platchek, Wensheng Xie, Julius del Rosario, Mohamad Nayal, Quinn Lu, Theresa Roethke, Christine G. Schnackenberg, Fe Wright, Michael P. Quaile, Wendy S. Halsey, Ashley M. Hughes, Ganesh M. Sathe, George P. Livi, Robert B. Kirkpatrick, Xiaoyan A. Qu, Deepak K. Rajpal, Maria Faelth Savitski, Marcus Bantscheff, Gerard Joberty, Giovanna Bergamini, Thomas L. Force, Gregory J. Gatto, Erding Hu, Robert N. Willette
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 5 (2017)
BackgroundThe amino acid response (AAR) is an evolutionarily conserved protective mechanism activated by amino acid deficiency through a key kinase, general control nonderepressible 2. In addition to mobilizing amino acids, the AAR broadly affects ge
Externí odkaz:
https://doaj.org/article/1c805dc589c7489c9f517443145877c9
Autor:
Carl A. Machutta, Christopher S. Kollmann, Kenneth E. Lind, Xiaopeng Bai, Pan F. Chan, Jianzhong Huang, Lluis Ballell, Svetlana Belyanskaya, Gurdyal S. Besra, David Barros-Aguirre, Robert H. Bates, Paolo A. Centrella, Sandy S. Chang, Jing Chai, Anthony E. Choudhry, Aaron Coffin, Christopher P. Davie, Hongfeng Deng, Jianghe Deng, Yun Ding, Jason W. Dodson, David T. Fosbenner, Enoch N. Gao, Taylor L. Graham, Todd L. Graybill, Karen Ingraham, Walter P. Johnson, Bryan W. King, Christopher R. Kwiatkowski, Joël Lelièvre, Yue Li, Xiaorong Liu, Quinn Lu, Ruth Lehr, Alfonso Mendoza-Losana, John Martin, Lynn McCloskey, Patti McCormick, Heather P. O’Keefe, Thomas O’Keeffe, Christina Pao, Christopher B. Phelps, Hongwei Qi, Keith Rafferty, Genaro S. Scavello, Matt S. Steiginga, Flora S. Sundersingh, Sharon M. Sweitzer, Lawrence M. Szewczuk, Amy Taylor, May Fern Toh, Juan Wang, Minghui Wang, Devan J. Wilkins, Bing Xia, Gang Yao, Jean Zhang, Jingye Zhou, Christine P. Donahue, Jeffrey A. Messer, David Holmes, Christopher C. Arico-Muendel, Andrew J. Pope, Jeffrey W. Gross, Ghotas Evindar
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
Nature Communications 8: Article number: 16081 (2017); Published: 17 July 2017, Updated: 13 July 2018 The original version of this Article omitted the following from the Acknowledgements: ‘We thank Robert Kirkpatrick for implementing the high throu
Externí odkaz:
https://doaj.org/article/ee8d0f7b2ad14f48b638c180d558c296
Autor:
Tanya Hosfield, Quinn Lu
Publikováno v:
BioTechniques, Vol 25, Iss 2, Pp 306-309 (1998)
We have constructed an epitope-tagging vector, pCMV-Tag 1, for gene expression in mammalian cells. This vector, which allows for N-terminal, C-terminal and internal tagging of the gene product of interest with the FLAG® and/or c-myc epitopes, enable
Externí odkaz:
https://doaj.org/article/0e77a914581d464f9a6d27374cdb8638
Autor:
Tanya Hosfield, Quinn Lu
Publikováno v:
BioTechniques, Vol 27, Iss 1, Pp 58-60 (1999)
Externí odkaz:
https://doaj.org/article/caa410cba411484eb44274408d41769a
Publikováno v:
Genome Editing in Drug Discovery. :47-59
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc40c34bdceac870138810c1c14209dd
https://doi.org/10.1002/9781119671404.ch4
https://doi.org/10.1002/9781119671404.ch4
Publikováno v:
SLAS Discovery. 25:1197-1213
Cytokines and their receptors play critical roles in biological processes. Dysfunction or dysregulation of cytokines may cause a variety of pathophysiological conditions. Consequently, cytokine profiling and related technologies are essential for bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd2e34ddf0bccd95a2d6c6ce07bb35c
https://doi.org/10.1177/2472555220954389
https://doi.org/10.1177/2472555220954389
Autor:
Adolfo Alfonso-Pecchio, Wangfang Hou, Stephen S. Wilson, Quinn Lu, Shu Zhang, Michelle L. Kimberland, Yanhua Rao
Publikováno v:
Journal of Biotechnology. 284:91-101
The CRISPR/Cas9 system has enabled efficient modification of genes in a variety of cellular systems for studying phenotypic effects of genetic perturbations. However, with this technology comes the inherent risk of generating off-target effects (OTEs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b471260f5e73a16c8827f81dbfb0b5ab
https://doi.org/10.1016/j.jbiotec.2018.08.007
https://doi.org/10.1016/j.jbiotec.2018.08.007
Autor:
Quinn Lu, Tiger W. Bee, Pankaj K. Agarwal, Dwight M. Morrow, Xin Zeng, Zining Wu, Monica N. Montoute, Hong Lin, Andrew J. Pope, Yan Liu, Da-Yuan Wang, Lorena A. Kallal
Publikováno v:
SLAS Discovery. 21:260-268
Abnormal accumulation of β-catenin protein, a key transcriptional activator required for Wnt signaling, is the hallmark of many tumor types, including colon cancer. In normal cells, β-catenin protein level is tightly controlled by a multiprotein co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f29be05bd84e79ed27e00301943936
https://doi.org/10.1177/1087057115620169
https://doi.org/10.1177/1087057115620169