Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Quinlyn A. Soltow"'
Autor:
Young-Mi Go, Yongliang Liang, Karan Uppal, Quinlyn A Soltow, Daniel E L Promislow, Lynn M Wachtman, Dean P Jones
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147880 (2016)
Externí odkaz:
https://doaj.org/article/e8f521ce945b40e38241817be7b879ae
Autor:
Karan eUppal, Quinlyn A Soltow, Daniel E. L. Promislow, Lynn M. Wachtman, Arshed Ali Quyyumi, Dean P. Jones
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 3 (2015)
Liquid-chromatography high-resolution mass spectrometry provides capability to measure >40,000 ions derived from metabolites in biologic samples. This presents challenges to confirm identities of known chemicals and delineate potential metabolic path
Externí odkaz:
https://doaj.org/article/429fd578677544508a8b2ac0fbb6a690
Autor:
Young-Mi Go, Yongliang Liang, Karan Uppal, Quinlyn A Soltow, Daniel E L Promislow, Lynn M Wachtman, Dean P Jones
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142916 (2015)
High-resolution metabolomics has created opportunity to integrate nutrition and metabolism into genetic studies to improve understanding of the diverse radiation of primate species. At present, however, there is very little information to help guide
Externí odkaz:
https://doaj.org/article/fbbb515007334fbe9905333ca2dfc480
Autor:
Shuzhao Li, Youngja Park, Sai Duraisingham, Frederick H Strobel, Nooruddin Khan, Quinlyn A Soltow, Dean P Jones, Bali Pulendran
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 7, p e1003123 (2013)
The functional interpretation of high throughput metabolomics by mass spectrometry is hindered by the identification of metabolites, a tedious and challenging task. We present a set of computational algorithms which, by leveraging the collective powe
Externí odkaz:
https://doaj.org/article/c57501b2771d4ce494384c53719163f1
Publikováno v:
Antimicrobial Agents and Chemotherapy. 64
Manogepix (MGX) targets the conserved fungal Gwt1 enzyme required for acylation of inositol early in the glycosylphosphatidylinositol biosynthesis pathway. The prodrug fosmanogepix is currently in clinical development for the treatment of invasive fu
Autor:
Quinlyn A. Soltow, Jonathan A. Covel, Peter J. Webb, Karen Joy Shaw, Marc D. Sharp, Michael Trzoss, Mili Kapoor, Molly K. Moloney
Publikováno v:
Medicinal Chemistry Reviews ISBN: 9780996293280
Medicinal Chemistry Reviews
Medicinal Chemistry Reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71579f0a5afd254384e8c0605e33853b
https://doi.org/10.29200/acsmedchemrev-v54.ch10
https://doi.org/10.29200/acsmedchemrev-v54.ch10
Autor:
Mehdi Michel Djamel Numa, Molly K. Moloney, Nambu Mitchell David, Robert R. Webb, Michael Trzoss, Mili Kapoor, Jonathan A. Covel, Quinlyn A. Soltow, Mitchell Mutz, Xiaoming Li, Peter J. Webb
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2465-2471
A novel antifungal strategy targeting the inhibition of calcineurin is described. To develop a calcineurin based inhibitor of pathogenic fungi, analogs of FK506 were synthesized that were able to permeate mammalian but not fungal cells. Antagonists i
Autor:
Jonathan Covel, Joshua Fierer, Sharon Okamoto, Karen Joy Shaw, Michael Trzoss, Quinlyn A. Soltow, Suganya Viriyakosol, Mili Kapoor
Publikováno v:
Antimicrobial Agents and Chemotherapy
Coccidioidomycosis is a systemic fungal infection caused by the inhalation of the arthroconidia of either of two closely related dimorphic fungi, Coccidioides immitis and C. posadasii, that are endemic in the southwestern United States and other area
Autor:
John R. Perfect, Jennifer L. Tenor, Quinlyn A. Soltow, Jane-Valeriane Boua, Julia R Palmucci, Dena L. Toffaletti, Karen J Shaw, Charles Giamberardino, Choiselle Marius
Publikováno v:
Open Forum Infectious Diseases
Background Cryptococcal meningitis (CM), caused primarily by Cryptococcus neoformans, is uniformly fatal if not treated. Treatment options are limited especially in resource-poor geographical regions, and mortality rates remain high despite current t
Autor:
Mili Kapoor, Quinlyn A. Soltow, Michael Trzoss, Molly K. Moloney, Jonathan A. Covel, Peter J. Webb, Karen Joy Shaw
Publikováno v:
Bioorg Med Chem Lett
Fosmanogepix (APX001) is a first-in-class prodrug molecule that is currently in Phase 2 clinical trials for invasive fungal infections. The active moiety manogepix (APX001A) inhibits the novel fungal protein Gwt1. Gwt1 catalyzes an early step in the