Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Quinlan L. Sievers"'
Autor:
Ricardo de Matos Simoes, Ryosuke Shirasaki, Sondra L. Downey-Kopyscinski, Geoffrey M. Matthews, Benjamin G. Barwick, Vikas A. Gupta, Daphné Dupéré-Richer, Shizuka Yamano, Yiguo Hu, Michal Sheffer, Eugen Dhimolea, Olga Dashevsky, Sara Gandolfi, Kazuya Ishiguro, Robin M. Meyers, Jordan G. Bryan, Neekesh V. Dharia, Paul J. Hengeveld, Johanna B. Brüggenthies, Huihui Tang, Andrew J. Aguirre, Quinlan L. Sievers, Benjamin L. Ebert, Brian J. Glassner, Christopher J. Ott, James E. Bradner, Nicholas P. Kwiatkowski, Daniel Auclair, Joan Levy, Jonathan J. Keats, Richard W. J. Groen, Nathanael S. Gray, Aedin C. Culhane, James M. McFarland, Joshua M. Dempster, Jonathan D. Licht, Lawrence H. Boise, William C. Hahn, Francisca Vazquez, Aviad Tsherniak, Constantine S. Mitsiades
Publikováno v:
de Matos Simoes, R, Shirasaki, R, Downey-Kopyscinski, S L, Matthews, G M, Barwick, B G, Gupta, V A, Dupéré-Richer, D, Yamano, S, Hu, Y, Sheffer, M, Dhimolea, E, Dashevsky, O, Gandolfi, S, Ishiguro, K, Meyers, R M, Bryan, J G, Dharia, N V, Hengeveld, P J, Brüggenthies, J B, Tang, H, Aguirre, A J, Sievers, Q L, Ebert, B L, Glassner, B J, Ott, C J, Bradner, J E, Kwiatkowski, N P, Auclair, D, Levy, J, Keats, J J, Groen, R W J, Gray, N S, Culhane, A C, McFarland, J M, Dempster, J M, Licht, J D, Boise, L H, Hahn, W C, Vazquez, F, Tsherniak, A & Mitsiades, C S 2023, ' Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias ', Nature Cancer, vol. 4, no. 5, pp. 754-773 . https://doi.org/10.1038/s43018-023-00550-x
Nature Cancer, 4(5), 754-773. Nature Research
Nature Cancer, 4(5), 754-773. Nature Research
Clinical progress in multiple myeloma (MM), an incurable plasma cell (PC) neoplasia, has been driven by therapies that have limited applications beyond MM/PC neoplasias and do not target specific oncogenic mutations in MM. Instead, these agents targe
Autor:
Dennis Gillingham, Jessica A. Gasser, Rob S. Sellar, Eric S. Fischer, Max Jan, Todd R. Golub, Manisha Manojkumar, Nicolas H. Thomä, Quinlan L. Sievers, Claudia Scholl, Stefan Fröhling, Li R. Wang, Zuzanna Kozicka, Katherine A. Donovan, Emma C. Fink, Adam S. Sperling, Yen-Der Li, Steven M. Corsello, Mikolaj Slabicki, Richard D. Bunker, Georg Petzold, Benjamin L. Ebert, Dakota Suchyta, Jonas Koeppel
Publikováno v:
Nature
Molecular glue compounds induce protein–protein interactions that, in the context of a ubiquitin ligase, lead to protein degradation. Unlike traditional enzyme inhibitors, these molecular glue degraders act substoichiometrically to catalyse the rap
Autor:
Daniel E Grinshpun, Mikolaj Slabicki, Taeyoon Kyung, Quinlan L. Sievers, Michael Kann, Rebecca C. Larson, Amanda Walker, Max Jan, Alexander Tepper, Andrea Schmidts, Benjamin L. Ebert, Maria L. Cabral, Marcela V. Maus, Michael E. Birnbaum, Jessica A. Gasser, Amanda A. Bouffard, Andrew A Guirguis, Irene Scarfò, Ana P. Castano, Adam S. Sperling
Publikováno v:
Sci Transl Med
PMC
PMC
Cell-based therapies are emerging as effective agents against cancer and other diseases. As autonomous “living drugs,” these therapies lack precise control. Chimeric antigen receptor (CAR) T cells effectively target hematologic malignancies but c
Autor:
Constantine S. Mitsiades, Joshua M. Dempster, Lawrence H. Boise, Aedín C. Culhane, Sondra L. Downey-Kopyscinski, Jonathan D. Licht, Hu Yiguo, Quinlan L. Sievers, William C. Hahn, Johanna Brueggenthies, John G. Doench, Christopher J. Ott, Geoffrey M. Matthews, Jordan Bryan, Jonathan J Keats, Francisca Vazquez, Joan Levy, Sara Gandolfi, Ricardo De Matos Simoes, Benjamin L. Ebert, Aviad Tsherniak, Huihui Tang, Daniel Auclair, Robin M. Meyers, Olga Dashevsky, Megan Bariteau, Ryosuke Shirasaki, Richard W.J. Groen, James M. McFarland, Minasri Borah, Brian J. Glassner, Nathanael S. Gray, Nicholas Kwiatkowski, Michal Sheffer, Eugen Dhimolea
Publikováno v:
Simoes, R D M, Shirasaki, R, Downey-Kopyscinski, S L, Matthews, G, Yiguo, H, Sheffer, M, Dhimolea, E, Dashevsky, O, Gandolfi, S, Dempster, J, Meyers, R M, Bryan, J, McFarland, J M, Brueggenthies, J, Tang, H, Bariteau, M, Borah, M, Sievers, Q L, Ebert, B, Glassner, B, Ott, C J, Kwiatkowski, N P, Doench, J G, Auclair, D, Levy, J, Boise, L H, Keats, J J, Licht, J D, Groen, R, Gray, N, Culhane, A, Hahn, W C, Vazquez, F, Tsherniak, A & Mitsiades, C S 2019, ' Systematic Characterization of Genes Representing Preferential Molecular Vulnerabilities for Myeloma Cells Compared to Other Neoplasias-Implications for the Biology and Therapeutic Targeting of Myeloma ', Blood, vol. 134 . https://doi.org/10.1182/blood-2019-130901
Blood, 134. American Society of Hematology
Blood, 134. American Society of Hematology
In the last 2 decades, the improved clinical outcomes for multiple myeloma (MM) patients have been driven predominantly by therapeutics which exhibit limited activity outside plasma cell (PC) dyscrasias; do not target specific oncogenic mutations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5c565d67e6f143da1ca00b515db1ad
https://research.vumc.nl/en/publications/5fb40b9b-df16-4a02-bb0a-8f5a34dd6eb4
https://research.vumc.nl/en/publications/5fb40b9b-df16-4a02-bb0a-8f5a34dd6eb4
Autor:
Paul G. Richardson, Benjamin L. Ebert, Constantine S. Mitsiades, Sondra L. Downey-Kopyscinski, Quinlan L. Sievers, Jacob P. Laubach, Eugen Dhimolea, Aedín C. Culhane, Joseline Raja, Olga Dashevsky, Geoffrey M. Matthews, Lawrence H. Boise, Eric S. Fischer, Megan Bariteau, Francisca Vazquez, Ricardo De Matos Simoes, Jonathan D. Licht, James E. Bradner, Michal Sheffer, Huihui Tang, Robert L. Schlossman, Tinghu Zhang, Christopher J. Ott, Nathanael S. Gray, Daniel Auclair, Aviad Tsherniak, Richard W.J. Groen, Ryosuke Shirasaki, Nicholas Kwiatkowski, Sara Gandolfi, Dennis L. Buckley, William C. Hahn, Paul J. Hengeveld, Haley Poarch, Brian J. Glassner, Joan Levy, Jonathan J Keats
Publikováno v:
Shirasaki, R, Gandolfi, S, Simoes, R D M, Matthews, G M, Buckley, D, Raja, J, Sievers, Q L, Dashevsky, O, Poarch, H, Tang, H, Bariteau, M, Sheffer, M, Downey-Kopyscinski, S L, Hengeveld, P, Glassner, B, Dhimolea, E, Ott, C J, Zhang, T, Kwiatkowski, N P, Laubach, J P, Schlossman, R L, Richardson, P G, Culhane, A, Groen, R W J, Fischer, E, Ebert, B L, Vazquez, F, Tsherniak, A, Hahn, W C, Levy, J, Auclair, D, Licht, J D, Keats, J J, Boise, L H, Bradner, J, Gray, N & Mitsiades, C S 2019, ' Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins ', Blood, vol. 134 . https://doi.org/10.1182/blood-2019-130549
Blood, 134. American Society of Hematology
Blood, 134. American Society of Hematology
The discovery that thalidomide derivatives recruit the E3 ligase CRBN to induce neomorphic degradation of proteins critical for multiple myeloma (MM) cells stimulated the research into proteolysis-targeting chimeric compounds (PROTACs), led to develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010396339ca0ccc2d1148ed6135544fb
https://research.vumc.nl/en/publications/a262da2f-f489-473e-b090-d72e765547f7
https://research.vumc.nl/en/publications/a262da2f-f489-473e-b090-d72e765547f7
Publikováno v:
Blood. 136:12-13
While a number of targeted therapies have recently become available in the treatment of acute myeloid leukemia (AML), it remains to be determined whether early acquired mutations are essential for ongoing leukemia maintenance in the face of sequentia
Autor:
Quinlan L. Sievers, Wassim Abdulrahman, Aline Renneville, Brian Liddicoat, Richard D. Bunker, Georg Petzold, Benjamin L. Ebert, Tarjei S. Mikkelsen, Nicolas H. Thomä
Publikováno v:
Molecular Cancer Therapeutics. 18:PL02-03
The small molecule drugs thalidomide, lenalidomide, and pomalidomide induce the ubiquitination and proteasomal degradation of Ikaros (IKZF1) and Aiolos (IKZF3) by mediating their interaction with Cereblon (CRBN), the substrate receptor of the CRL4CRB
Autor:
Mikolaj Slabicki, Eric Kuhn, Quinlan L. Sievers, Namrata D. Udeshi, Jessica A. Gasser, Adam S. Sperling, Rob S. Sellar, Hasmik Keshishian, Michael Burgess, Elyse A. Olesinski, Benjamin L. Ebert, Steven A. Carr, Rohan Sharma, Anthony Letai, Peter Miller, Shruti Bhatt, Max Jan, Brian J. Liddicoat, Mariateresa Fulciniti, Emma C. Fink, Dylan N. Adams, Nikhil C. Munshi
Publikováno v:
Blood. 134(2)
Pharmacologic agents that modulate ubiquitin ligase activity to induce protein degradation are a major new class of therapeutic agents, active in a number of hematologic malignancies. However, we currently have a limited understanding of the determin
Autor:
Quinlan L. Sievers, Georg Petzold, Richard D. Bunker, Aline Renneville, Mikołaj Słabicki, Brian Liddicoat, Wassim Abdulrahman, Tarjei Mikkelsen, Benjamin L. Ebert, Nicolas H. Thomä
The small molecule drugs thalidomide, lenalidomide, and pomalidomide induce ubiquitination and proteasomal degradation of the zinc finger transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) by recruitment to Cereblon (CRBN), the substrate recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2659::b8d7b26e8dfbc100c58910f9412d7050
https://zenodo.org/record/4412242
https://zenodo.org/record/4412242
Autor:
Dennis L. Buckley, Aviad Tsherniak, Nicholas Kwiatkowski, Ryosuke Shirasaki, Jonathan J Keats, William C. Hahn, Paul J. Hengeveld, Haley Poarch, James E. Bradner, Aedín C. Culhane, Joan Levy, Jacob P. Laubach, Huihui Tang, Geoffrey M. Matthews, Megan Bariteau, Yiguo Hu, Lawrence H. Boise, Paul G. Richardson, Eric S. Fischer, Jonathan D. Licht, Quinlan L. Sievers, Ricardo De Matos Simoes, Tinghu Zhang, Brian J. Glassner, Francisca Vazquez, Johanna Bruggenthies, Constantine S. Mitsiades, Robert L. Schlossman, Daniel Auclair, Richard W.J. Groen, Sondra L. Downey-Kopyscinski, Nathanael S. Gray, Sara Gandolfi, Benjamin L. Ebert, Olga Dashevsky, Christopher J. Ott, Joseline Raja Vora, Michal Sheffer, Eugen Dhimolea
Publikováno v:
Cell Rep
Cell Reports, 34(1):108532. Cell Press
Shirasaki, R, Matthews, G M, Gandolfi, S, de Matos Simoes, R, Buckley, D L, Raja Vora, J, Sievers, Q L, Brüggenthies, J B, Dashevsky, O, Poarch, H, Tang, H, Bariteau, M A, Sheffer, M, Hu, Y, Downey-Kopyscinski, S L, Hengeveld, P J, Glassner, B J, Dhimolea, E, Ott, C J, Zhang, T, Kwiatkowski, N P, Laubach, J P, Schlossman, R L, Richardson, P G, Culhane, A C, Groen, R W J, Fischer, E S, Vazquez, F, Tsherniak, A, Hahn, W C, Levy, J, Auclair, D, Licht, J D, Keats, J J, Boise, L H, Ebert, B L, Bradner, J E, Gray, N S & Mitsiades, C S 2021, ' Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins ', Cell Reports, vol. 34, no. 1, 108532 . https://doi.org/10.1016/j.celrep.2020.108532
Cell Reports, 34(1):108532. Cell Press
Shirasaki, R, Matthews, G M, Gandolfi, S, de Matos Simoes, R, Buckley, D L, Raja Vora, J, Sievers, Q L, Brüggenthies, J B, Dashevsky, O, Poarch, H, Tang, H, Bariteau, M A, Sheffer, M, Hu, Y, Downey-Kopyscinski, S L, Hengeveld, P J, Glassner, B J, Dhimolea, E, Ott, C J, Zhang, T, Kwiatkowski, N P, Laubach, J P, Schlossman, R L, Richardson, P G, Culhane, A C, Groen, R W J, Fischer, E S, Vazquez, F, Tsherniak, A, Hahn, W C, Levy, J, Auclair, D, Licht, J D, Keats, J J, Boise, L H, Ebert, B L, Bradner, J E, Gray, N S & Mitsiades, C S 2021, ' Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins ', Cell Reports, vol. 34, no. 1, 108532 . https://doi.org/10.1016/j.celrep.2020.108532
Heterobifunctional proteolysis-targeting chimeric compounds leverage the activity of E3 ligases to induce degradation of target oncoproteins and exhibit potent preclinical antitumor activity. To dissect the mechanisms regulating tumor cell sensitivit