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Multiscale integration of human and single-cell variations reveals unadjuvanted vaccine high responders are naturally adjuvanted.

Autor: Mulè MP; Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, USA.; NIH-Oxford-Cambridge Scholars Program; Department of Medicine, University of Cambridge, Cambridge, UK., Martins AJ; Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, USA., Cheung F; NIH Center for Human Immunology, NIAID, NIH, Bethesda, MD, USA., Farmer R; NIH Center for Human Immunology, NIAID, NIH, Bethesda, MD, USA., Sellers B; NIH Center for Human Immunology, NIAID, NIH, Bethesda, MD, USA., Quiel JA; NIH Center for Human Immunology, NIAID, NIH, Bethesda, MD, USA., Jain A; Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, USA., Kotliarov Y; NIH Center for Human Immunology, NIAID, NIH, Bethesda, MD, USA., Bansal N; Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, USA., Chen J; NIH Center for Human Immunology, NIAID, NIH, Bethesda, MD, USA., Schwartzberg PL; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.; Cell Signaling and Immunity Section, NIAID, NIH, Bethesda, MD, USA., Tsang JS; Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, USA.; NIH Center for Human Immunology, NIAID, NIH, Bethesda, MD, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2023 Mar 20. Date of Electronic Publication: 2023 Mar 20.

Restoration of the type I IFN-IL-1 balance through targeted blockade of PTGER4 inhibits autoimmunity in NOD mice.

Autor: Rahman MJ; Immune Tolerance Section, Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, Maryland, USA.; Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA., Rodrigues KB; Immune Tolerance Section, Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, Maryland, USA., Quiel JA; Immune Tolerance Section, Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, Maryland, USA., Liu Y; Immune Tolerance Section, Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, Maryland, USA., Bhargava V; Janssen Research and Development, Spring House, Philadelphia, Pennsylvania, USA., Zhao Y; Immune Tolerance Section, Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, Maryland, USA., Hotta-Iwamura C; Immune Tolerance Section, Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, Maryland, USA., Shih HY; Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA., Lau-Kilby AW; Laboratory of Neonatal Infection and Immunity, Department of Pediatrics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA., Malloy AM; Laboratory of Neonatal Infection and Immunity, Department of Pediatrics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA., Thoner TW; Immune Tolerance Section, Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, Maryland, USA., Tarbell KV; Immune Tolerance Section, Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, Maryland, USA.; Amgen Discovery Research, Inflammation and Oncology, South San Francisco, California, USA.

Publikováno v: JCI insight [JCI Insight] 2018 Feb 08; Vol. 3 (3). Date of Electronic Publication: 2018 Feb 08 (Print Publication: 2018).