Synthesis and evaluation of cis-hexahydropyrrolo[3,2- b]pyrrol-3-one peptidomimetic inhibitors of CAC1 cysteinyl proteinases

Autor: Quibell, Martin ^*, Benn, Alex, Flinn, Nick, Monk, Tracy, Ramjee, Manoj, Ray, Peter, Wang, Yikang, Watts, John

Publikováno v: In Bioorganic & Medicinal Chemistry 2005 13(3):609-625

Functionalised 2,3-dimethyl-3-aminotetrahydrofuran-4-one and N-(3-oxo-hexahydrocyclopenta[ b]furan-3 a-yl)acylamide based scaffolds: synthesis and cysteinyl proteinase inhibition

Autor: Watts, John, Benn, Alex, Flinn, Nick, Monk, Tracy, Ramjee, Manoj, Ray, Peter, Wang, Yikang, Quibell, Martin

Publikováno v: In Bioorganic & Medicinal Chemistry 2004 12(11):2903-2925

Peptide Synthesis Hot Paper HF-Free Boc Synthesis of Peptide Thioesters for Ligation and Cyclization

Autor: Raz, Richard, Burlina, Fabienne, Ismail, Mohamed, Downward, Julian, Li, Jiejin, Smerdon, Stephen J., Quibell, Martin, White, Peter D., Offer, John

Publikováno v: Angewandte Chemie
Angewandte Chemie, 2016, 128 (42), pp.13368-13373 ⟨10.1002/ange.201607657⟩
Angewandte Chemie, Wiley-VCH Verlag, 2016, 128 (42), pp.13368-13373 ⟨10.1002/ange.201607657⟩

International audience; We have developed a convenient method for the direct synthesis of peptide thioesters, versatile intermediates for peptide ligation and cyclic peptide synthesis. The technology uses a modified Boc SPPS strategy that avoids the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6662f88db79cdab798b0b6f11c2dfb93
https://hal.sorbonne-universite.fr/hal-01371556

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