Asociación entre reabsorción radicular en dientes primarios y el desarrollo de sucesores permanentes en radiografías panorámicas de niños, Chiclayo, 2017-2019

Autor: Quevedo Celis, Karla Isolina

El objetivo del estudio fue asociar la reabsorción radicular en dientes primarios y el desarrollo de sucesores permanentes en radiografías panorámicas de niños, Chiclayo, 2017-2019. El estudio fue cuantitativo, observacional, transversal. La pobl

Externí odkaz: http://hdl.handle.net/20.500.12423/6709

Aminothiazolones as potent, selective and cell active inhibitors of the PIM kinase family.

Autor: Quevedo CE; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK., Bataille CJR; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK., Byrne S; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK., Durbin M; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK., Elkins J; Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, UK., Guillermo A; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK., Jones AM; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK., Knapp S; Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, UK., Nadali A; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK., Walker RG; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK., Wilkinson IVL; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK., Wynne GM; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK., Davies SG; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK., Russell AJ; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK. Electronic address: angela.russell@chem.ox.ac.uk.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2020 Nov 15; Vol. 28 (22), pp. 115724. Date of Electronic Publication: 2020 Aug 26.

Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.

Autor: Quevedo CE; Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK., Cruz-Migoni A; Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, Oxon, OX11 0FA, UK., Bery N; Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK., Miller A; Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK., Tanaka T; Leeds Institute for Molecular Medicine, St James University Hospital, Leeds, LS9 7TF, UK.; Research & Development, Sanofi K.K., Tokyo Opera City Tower, 3-20-2, Nishi Shinjuku, Shinjuku-ku, Tokyo, 163-1488, Japan., Petch D; Leeds Institute for Molecular Medicine, St James University Hospital, Leeds, LS9 7TF, UK., Bataille CJR; Chemistry Research Laboratory, 12 Mansfield Rd, Oxford, OX1 3TA, UK., Lee LYW; Domainex, Chesterford Research Park, Little Chesterford, Saffron Walden, CB10 1XL, UK., Fallon PS; Domainex, Chesterford Research Park, Little Chesterford, Saffron Walden, CB10 1XL, UK., Tulmin H; Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.; Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK., Ehebauer MT; Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.; Oxford Drug Discovery Institute, Nuffield Department of Medicine Research Building, University of Oxford, Old Road Campus, Oxford, OX3 7FZ, UK., Fernandez-Fuentes N; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, Oxon, OX11 0FA, UK.; Institute of Biological, Environmental and Rural Sciences, University of Aberystwyth, Aberystwyth, SY23 3EB, UK., Russell AJ; Chemistry Research Laboratory, 12 Mansfield Rd, Oxford, OX1 3TA, UK., Carr SB; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, Oxon, OX11 0FA, UK.; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK., Phillips SEV; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, Oxon, OX11 0FA, UK.; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK., Rabbitts TH; Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK. terence.rabbitts@imm.ox.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2018 Aug 09; Vol. 9 (1), pp. 3169. Date of Electronic Publication: 2018 Aug 09.

BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions.

Autor: Bery N; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom., Cruz-Migoni A; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, United Kingdom., Bataille CJ; Chemistry Research Laboratory, Oxford, United Kingdom., Quevedo CE; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom., Tulmin H; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom., Miller A; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom., Russell A; Chemistry Research Laboratory, Oxford, United Kingdom., Phillips SE; Department of Biochemistry, University of Oxford, Oxford, United Kingdom., Carr SB; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, United Kingdom.; Department of Biochemistry, University of Oxford, Oxford, United Kingdom., Rabbitts TH; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.

Publikováno v: ELife [Elife] 2018 Jul 10; Vol. 7. Date of Electronic Publication: 2018 Jul 10.

Thiazolidine derivatives as potent and selective inhibitors of the PIM kinase family.

Autor: Bataille CJ; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK., Brennan MB; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK., Byrne S; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK., Davies SG; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK. Electronic address: steve.davies@chem.ox.ac.uk., Durbin M; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK., Fedorov O; Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, UK., Huber KV; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK., Jones AM; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK., Knapp S; Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, UK., Liu G; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK., Nadali A; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK., Quevedo CE; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK., Russell AJ; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK. Electronic address: angela.russell@chem.ox.ac.uk., Walker RG; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK., Westwood R; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK., Wynne GM; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2017 May 01; Vol. 25 (9), pp. 2657-2665. Date of Electronic Publication: 2017 Feb 28.