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Autor:
Mougel, Gregory, Mondielli, Grégoire, Appay, R, Querdray, Adeline, Roche, C, Jijon, A, Konstantinova, I, Soude, A, Graillon, Thomas, Barlier, Anne
Publikováno v:
Neuro-Oncology
Neuro-Oncology, 2022, 24 (Supplement_2), pp.ii95-ii95. ⟨10.1093/neuonc/noac174.334⟩
Neuro-Oncology, 2022, 24 (Supplement_2), pp.ii95-ii95. ⟨10.1093/neuonc/noac174.334⟩
Background Recurrent and aggressive meningiomas remain an unmet medical need in neuro-oncology. In mammals, Hippo signaling pathway is responsible for the growth of organs by regulating cell proliferation and apoptosis. The tumor suppressor NF2 prote
Autor:
Gregoire Mondielli, Gregory Mougel, Florent Darriet, Catherine Roche, Adeline Querdray, Christophe Lisbonis, Romain Appay, Henry Dufour, Olivier Chinot, Thomas Graillon, Anne Barlier
Publikováno v:
Cancers; Volume 14; Issue 18; Pages: 4448
Cancers
Cancers, 2022, 14 (18), pp.4448. ⟨10.3390/cancers14184448⟩
Cancers
Cancers, 2022, 14 (18), pp.4448. ⟨10.3390/cancers14184448⟩
International audience; Recurrent or high-grade meningiomas are an unmet medical need. Recently, we demonstrated that targeting mTOR by everolimus was relevant both in vitro and in humans. However, everolimus induces an AKT activation that may impact
Autor:
Thomas Cuny, Peter M. van Koetsveld, Grégoire Mondielli, Fadime Dogan, Wouter W. de Herder, Anne Barlier, Leo J. Hofland
Publikováno v:
Cancers
Cancers, MDPI, 2022, 14 (14), pp.3481. ⟨10.3390/cancers14143481⟩
Cancers, 14(14):3481. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers; Volume 14; Issue 14; Pages: 3481
Cancers, MDPI, 2022, 14 (14), pp.3481. ⟨10.3390/cancers14143481⟩
Cancers, 14(14):3481. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers; Volume 14; Issue 14; Pages: 3481
Introduction: Pancreatic neuroendocrine neoplasms (PNENs) present with a fibrotic stroma that constitutes the tumor microenvironment (TME). The role played by stromal fibroblasts in the growth of PNENs and their sensitivity to the mTOR inhibitor RAD0