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pro vyhledávání: '"Quentin T. L. Pasquer"'
Autor:
Meropi Bagka, Hyeonyi Choi, Margaux Héritier, Hanna Schwaemmle, Quentin T. L. Pasquer, Simon M. G. Braun, Leonardo Scapozza, Yibo Wu, Sascha Hoogendoorn
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Target deconvolution of small molecule hits from phenotypic screens presents a major challenge. Many screens have been conducted to find inhibitors for the Hedgehog signaling pathway – a developmental pathway with many implications in heal
Externí odkaz:
https://doaj.org/article/b4d2bb81f1b045a88f120d6c8ceeb87e
Publikováno v:
Molecules, Vol 25, Iss 23, p 5702 (2020)
Biologically active small molecules have a central role in drug development, and as chemical probes and tool compounds to perturb and elucidate biological processes. Small molecules can be rationally designed for a given target, or a library of molec
Externí odkaz:
https://doaj.org/article/cdcacc17ceed4499ba2dd75b736e2889
Autor:
Javier López-Andarias, Quentin T. L. Pasquer, Naomi Sakai, Sascha Hoogendoorn, Stefan Matile, Lea Assies, Krikor Eblighatian
Publikováno v:
Angewandte Chemie, Vol. 61, No 1 (2022) P. e202113163
Mechanosensitive flipper probes are attracting interest as fluorescent reporters of membrane order and tension in biological systems. We introduce PhotoFlippers, which contain a photocleavable linker and an ultralong tether between mechanophore and v