Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Quentin McAfee"'
Autor:
Ravi K. Amaravadi, Jeffrey D. Winkler, David W. Speicher, Donita C. Brady, Roberto Zoncu, Meenhard Herlyn, Xiaowei Xu, Shujing Liu, Qin Liu, Ronen Marmorstein, Joshua Rabinowitz, Yiling Lu, Gordon B. Mills, Maureen E. Murphy, Julie S. Barber-Rotenberg, Zhi Wei, Samuel M. Levi, Rani Ojha, Sengottuvelan Murugan, Shengfu Piao, Gretchen M. Alicea, Gao Zhang, Cynthia I. Chude, Eric Witze, Chun-Yan Lim, Michel Nofal, Amruta Ronghe, Quentin McAfee, Colin Fennelly, Noel McLaughlin, Michael C. Nicastri, Vito W. Rebecca
Supplemental Chemical Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a73a32df39358814d1916585f5a9c6
https://doi.org/10.1158/2159-8290.22532497.v1
https://doi.org/10.1158/2159-8290.22532497.v1
Autor:
Ravi K. Amaravadi, Jeffrey D. Winkler, David W. Speicher, Donita C. Brady, Roberto Zoncu, Meenhard Herlyn, Xiaowei Xu, Shujing Liu, Qin Liu, Ronen Marmorstein, Joshua Rabinowitz, Yiling Lu, Gordon B. Mills, Maureen E. Murphy, Julie S. Barber-Rotenberg, Zhi Wei, Samuel M. Levi, Rani Ojha, Sengottuvelan Murugan, Shengfu Piao, Gretchen M. Alicea, Gao Zhang, Cynthia I. Chude, Eric Witze, Chun-Yan Lim, Michel Nofal, Amruta Ronghe, Quentin McAfee, Colin Fennelly, Noel McLaughlin, Michael C. Nicastri, Vito W. Rebecca
Supplemental Figures and Table
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757ddfcdc3c0b0e67e8ed83b0beed685
https://doi.org/10.1158/2159-8290.22532494
https://doi.org/10.1158/2159-8290.22532494
Autor:
Ravi K. Amaravadi, Jeffrey D. Winkler, David W. Speicher, Phyllis A. Gimotty, Ronen Marmorstein, Meenhard Herlyn, Xiaowei Xu, Lynn M. Schuchter, Jennifer J. Lee, Gretchen M. Alicea, Alessandra Martorella, Estela Noguera-Ortega, Shengfu Piao, Rani Ojha, Aaron R. Goldman, Gao Zhang, Noel P. McLaughlin, Quentin McAfee, Amruta Ronghe, Julie S. Barber-Rotenberg, Cynthia I. Chude, Colin Fennelly, Michael C. Nicastri, Vito W. Rebecca
Supplementary Figures S1-S4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ca2788b50fc025f26327d0ffe171ee
https://doi.org/10.1158/2159-8290.22532723.v1
https://doi.org/10.1158/2159-8290.22532723.v1
Autor:
Ravi K. Amaravadi, Jeffrey D. Winkler, David W. Speicher, Phyllis A. Gimotty, Ronen Marmorstein, Meenhard Herlyn, Xiaowei Xu, Lynn M. Schuchter, Jennifer J. Lee, Gretchen M. Alicea, Alessandra Martorella, Estela Noguera-Ortega, Shengfu Piao, Rani Ojha, Aaron R. Goldman, Gao Zhang, Noel P. McLaughlin, Quentin McAfee, Amruta Ronghe, Julie S. Barber-Rotenberg, Cynthia I. Chude, Colin Fennelly, Michael C. Nicastri, Vito W. Rebecca
Chemical Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2010550c1625be6ad5a3851e6f932430
https://doi.org/10.1158/2159-8290.22532726.v1
https://doi.org/10.1158/2159-8290.22532726.v1
Autor:
Ravi K. Amaravadi, Jeffrey D. Winkler, David W. Speicher, Phyllis A. Gimotty, Ronen Marmorstein, Meenhard Herlyn, Xiaowei Xu, Lynn M. Schuchter, Jennifer J. Lee, Gretchen M. Alicea, Alessandra Martorella, Estela Noguera-Ortega, Shengfu Piao, Rani Ojha, Aaron R. Goldman, Gao Zhang, Noel P. McLaughlin, Quentin McAfee, Amruta Ronghe, Julie S. Barber-Rotenberg, Cynthia I. Chude, Colin Fennelly, Michael C. Nicastri, Vito W. Rebecca
Clinical trials repurposing lysosomotropic chloroquine (CQ) derivatives as autophagy inhibitors in cancer demonstrate encouraging results, but the underlying mechanism of action remains unknown. Here, we report a novel dimeric CQ (DC661) capable of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31fbbe3005df3dacfe5a510f4e72acce
https://doi.org/10.1158/2159-8290.c.6546812
https://doi.org/10.1158/2159-8290.c.6546812
Autor:
Quentin McAfee, Christina Yingxian Chen, Yifan Yang, Matthew Caporizzo, Michael Morley, Apoorva Babu, Sunhye Jeong, Jeffrey Brandimarto, Kenneth Bedi, Emily Flam, Joseph Cesare, Thomas Cappola, Kenneth Margulies, Benjamin Prosser, Zoltan Arany
Publikováno v:
Journal of Molecular and Cellular Cardiology. 173:73-74
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b35702245ff3382a250e8420041fab5
https://doi.org/10.1016/j.yjmcc.2022.08.149
https://doi.org/10.1016/j.yjmcc.2022.08.149
Autor:
Alexia Vite, Matthew A. Caporizzo, Elise A. Corbin, Jeffrey Brandimarto, Quentin McAfee, Carissa E. Livingston, Benjamin L. Prosser, Kenneth B. Margulies
Publikováno v:
Basic Res Cardiol
The mechanical environment of the myocardium has a potent effect on cardiomyocyte form and function, yet an understanding of the cardiomyocyte responses to extracellular stiffening remains incomplete. We therefore employed a cell culture substrate wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b354dcd3a2782812f06a5f9072de730
https://europepmc.org/articles/PMC9899517/
https://europepmc.org/articles/PMC9899517/
Autor:
Nora Yucel, Silvia Marchiano, Evan Tchelepi, Germana Paterlini, Quentin McAfee, Nehaar Nimmagadda, Andy Ren, Sam Shi, Charles Murry, Zoltan Arany
How SARS-CoV-2 causes the observed range of clinical manifestations and disease severity remains poorly understood. SARS-CoV-2 encodes for two proteases (3CLPro and PLPro), vital for viral production, but also promiscuous with respect to host protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4804c0a588d842925f4de2e59203b14
https://doi.org/10.1101/2022.01.17.476677
https://doi.org/10.1101/2022.01.17.476677
Autor:
Christina Yingxian Chen, Michael Morley, Yifan Yang, Apoorva Babu, Kenneth Bedi, Zolt Arany, Thomas P. Cappola, Sunhye Jeong, Emily Flam, Kenneth B. Margulies, Matthew A. Caporizzo, Quentin McAfee, Benjamin L. Prosser, Joseph Cesare, Jeffrey Brandimarto
Publikováno v:
Sci Transl Med
Truncating variants in TTN (TTNtvs) are the most common known cause of nonischemic dilated cardiomyopathy (DCM), but how TTNtvs cause disease has remained controversial. Efforts to detect truncated titin proteins in affected human DCM hearts have fai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::884825a584fc488dfd3e6f8582ccf2c6
https://europepmc.org/articles/PMC9236909/
https://europepmc.org/articles/PMC9236909/
Publikováno v:
Circulation Research. 129
We hypothesized that the 3CL protease (3CLPro) is responsible for the sarcomere degradation observed in cardiomyocytes infected by SARS-COV2. Overexpression of 3CLPro, but not a catalytically inactive mutant, resulted in breakdown of sarcomeres chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c38fdc10db8ff18739ae4e4cd142d0b
https://doi.org/10.1161/res.129.suppl_1.112
https://doi.org/10.1161/res.129.suppl_1.112