Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Quentin M R Gibaut"'
Autor:
Yuquan Tong, Yeongju Lee, Xiaohui Liu, Jessica L. Childs-Disney, Blessy M. Suresh, Raphael I. Benhamou, Chunying Yang, Weimin Li, Matthew G. Costales, Hafeez S. Haniff, Sonja Sievers, Daniel Abegg, Tristan Wegner, Tiffany O. Paulisch, Elizabeth Lekah, Maison Grefe, Gogce Crynen, Montina Van Meter, Tenghui Wang, Quentin M. R. Gibaut, John L. Cleveland, Alexander Adibekian, Frank Glorius, Herbert Waldmann, Matthew D. Disney
Publikováno v:
Nature. 618:169-179
Target occupancy is often insufficient to elicit biological activity, particularly for RNA, compounded by the longstanding challenges surrounding the molecular recognition of RNA structures by small molecules. Here we studied molecular recognition pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ddd01fdc061bbc5774956f8b2b5aaea
https://doi.org/10.1038/s41586-023-06091-8
https://doi.org/10.1038/s41586-023-06091-8
Autor:
Quentin M. R. Gibaut, Yoshihiro Akahori, Jessica A. Bush, Amirhossein Taghavi, Toru Tanaka, Haruo Aikawa, Lucas S. Ryan, Brian M. Paegel, Matthew D. Disney
Publikováno v:
Journal of the American Chemical Society. 144:21972-21979
A solid-phase DNA-encoded library (DEL) was studied for binding the RNA repeat expansion r(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d70cedce48e526c9dd48ea07de84a3
https://doi.org/10.1021/jacs.2c08883
https://doi.org/10.1021/jacs.2c08883
Autor:
Jessica L. Childs-Disney, Xueyi Yang, Quentin M. R. Gibaut, Yuquan Tong, Robert T. Batey, Matthew D. Disney
Publikováno v:
Nature Reviews Drug Discovery. 21:736-762
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::938dece0be80ea56341e14ccddcdadd7
https://doi.org/10.1038/s41573-022-00521-4
https://doi.org/10.1038/s41573-022-00521-4
Autor:
Yuquan Tong, Quentin M. R. Gibaut, Warren Rouse, Jessica L. Childs-Disney, Blessy M. Suresh, Daniel Abegg, Shruti Choudhary, Yoshihiro Akahori, Alexander Adibekian, Walter N. Moss, Matthew D. Disney
Publikováno v:
J Am Chem Soc
The interactions between cellular RNAs in MDA-MB-231 triple negative breast cancer cells and a panel of small molecules appended with a diazirine cross-linking moiety and an alkyne tag were probed transcriptome-wide in live cells. The alkyne tag allo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f6fb0cc19b69f65a725b2ce3892e36e
https://doi.org/10.1021/jacs.2c01929
https://doi.org/10.1021/jacs.2c01929
Autor:
Tra D. Nguyen, Mahbobeh Lesani, Ines Forrest, Yunpeng Lan, Danya A. Dean, Quentin M. R. Gibaut, Yanting Guo, Ekram Hossain, Marcela Olvera, Hannah Panlilio, Adwaita R. Parab, Chaoyi Wu, Jean A. Bernatchez, Robert H. Cichewicz, Laura-Isobel McCall
Publikováno v:
Metabolites, Vol 10, Iss 3, p 86 (2020)
Soil covers most of Earth’s continental surface and is fundamental to life-sustaining processes such as agriculture. Given its rich biodiversity, soil is also a major source for natural product drug discovery from soil microorganisms. However, the
Externí odkaz:
https://doaj.org/article/fa06a1b5d1a04c50bf15a347caf2a5df
Autor:
Jessica A, Bush, Samantha M, Meyer, Rita, Fuerst, Yuquan, Tong, Yue, Li, Raphael I, Benhamou, Haruo, Aikawa, Patrick R A, Zanon, Quentin M R, Gibaut, Alicia J, Angelbello, Tania F, Gendron, Yong-Jie, Zhang, Leonard, Petrucelli, Torben, Heick Jensen, Jessica L, Childs-Disney, Matthew D, Disney
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(48)
A hexanucleotide repeat expansion in intron 1 of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1c18fcf4380e2f420c86dd2f4d3a8861
https://pubmed.ncbi.nlm.nih.gov/36409902
https://pubmed.ncbi.nlm.nih.gov/36409902
Autor:
Blessy M. Suresh, Yoshihiro Akahori, Amirhossein Taghavi, Gogce Crynen, Quentin M. R. Gibaut, Yue Li, Matthew D. Disney
Publikováno v:
Journal of the American Chemical Society. 144(45)
RNA is challenging to target with bioactive small molecules, particularly those of low molecular weight that bind with sufficient affinity and specificity. In this report, we developed a platform to address this challenge, affording a novel bioactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b07aaa55768e09e9f497219cf2f1097
https://pubmed.ncbi.nlm.nih.gov/36322830
https://pubmed.ncbi.nlm.nih.gov/36322830
Autor:
Jessica A. Bush, Samantha M. Meyer, Rita Fuerst, Yuquan Tong, Yue Li, Raphael I. Benhamou, Haruo Aikawa, Patrick R. A. Zanon, Quentin M. R. Gibaut, Alicia J. Angelbello, Tania F. Gendron, Yong-Jie Zhang, Leonard Petrucelli, Torben Heick Jensen, Jessica L. Childs-Disney, Matthew D. Disney
Publikováno v:
Bush, J A, Meyer, S M, Fuerst, R, Tong, Y, Li, Y, Benhamou, R I, Aikawa, H, Zanon, P R A, Gibaut, Q M R, Angelbello, A J, Gendron, T F, Zhang, Y J, Petrucelli, L, Heick Jensen, T, Childs-Disney, J L & Disney, M D 2022, ' A blood-brain penetrant RNA-targeted small molecule triggers elimination of r(G 4 C 2 ) exp in c9ALS/FTD via the nuclear RNA exosome ', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 48, e2210532119 . https://doi.org/10.1073/pnas.2210532119
A hexanucleotide repeat expansion in intron 1 of the C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia, or c9ALS/FTD. The RNA transcribed from the expansion, r(G 4 C 2 ) exp , causes various pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d99afbe6d3582820279ae53936a1dca4
https://pure.au.dk/portal/da/publications/a-bloodbrain-penetrant-rnatargeted-small-molecule-triggers-elimination-of-rg4c2exp-in-c9alsftd-via-the-nuclear-rna-exosome(c64b1cee-2f4b-4d36-8329-562cc33c1c4c).html
https://pure.au.dk/portal/da/publications/a-bloodbrain-penetrant-rnatargeted-small-molecule-triggers-elimination-of-rg4c2exp-in-c9alsftd-via-the-nuclear-rna-exosome(c64b1cee-2f4b-4d36-8329-562cc33c1c4c).html
Autor:
Yuquan Tong, Quentin M. R. Gibaut, Warren Rouse, Jessica L. Childs-Disney, Blessy M. Suresh, Daniel Abegg, Shruti Choudhary, Yoshihiro Akahori, Alexander Adibekian, Walter N. Moss, Matthew D. Disney
Publikováno v:
Journal of the American Chemical Society. 145:9364-9364
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6655ea99ffbc21a31fc5b8780e8dea9
https://doi.org/10.1021/jacs.3c02644
https://doi.org/10.1021/jacs.3c02644
Autor:
Mahbobeh Lesani, Quentin M R Gibaut, Ekram Hossain, Robert H. Cichewicz, Laura-Isobel McCall, Adwaita R. Parab, Jean A. Bernatchez, Chaoyi Wu, Yanting Guo, Ines Forrest, Danya A. Dean, Yunpeng Lan, Marcela Olvera, Tra D Nguyen, Hannah Panlilio
Publikováno v:
Metabolites
Metabolites; Volume 10; Issue 3; Pages: 86
Metabolites, Vol 10, Iss 3, p 86 (2020)
Metabolites; Volume 10; Issue 3; Pages: 86
Metabolites, Vol 10, Iss 3, p 86 (2020)
Soil covers most of Earth’s continental surface and is fundamental to life-sustaining processes such as agriculture. Given its rich biodiversity, soil is also a major source for natural product drug discovery from soil microorganisms. However, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c352b69222a75847aa99f3152616a3
http://europepmc.org/articles/PMC7143036
http://europepmc.org/articles/PMC7143036